Continuity 6 is a problem-solving environment for multi-scale modeling and data analysis in bioengineering and physiology, especially finite element modeling in cardiac biomechanics, biotransport and electrophysiology. Continuity 6 is distributed free for academic research by the National Biomedical Computation Resource (NBCR). Continuity 6 is portable, object-oriented, has separate GUI client and computational server components, and runs under Windows, MacOS or Linux, including Linux clusters.