reaction	left_comp	right_comp	left_smiles	right_smiles	Type of reaction (hydrolysis, reduction?)
DM1	BILR 355	BILR 402	CCN1C2=C(C=CC=N2)N(C(=O)C3=CC(=CN=C31)CCOC4=CC=[N+](C5=CC=CC=C54)[O-])C	CCN1C2=C(C=CC=N2)N(C(=O)C3=CC(=CN=C31)CCOC4=CC=NC5=CC=CC=C54)C	reduction
DM2	Clonazepam	7-aminoclonazepam	C1C(=O)NC2=C(C=C(C=C2)[N+](=O)[O-])C(=N1)C3=CC=CC=C3Cl	C1C(=O)NC2=C(C=C(C=C2)N)C(=N1)C3=CC=CC=C3Cl	reduction
DM3	Digoxin	dihydrodigoxin 	CC1C(C(CC(O1)OC2C(OC(CC2O)OC3C(OC(CC3O)OC4CCC5(C(C4)CCC6C5CC(C7(C6(CCC7C8=CC(=O)OC8)O)C)O)C)C)C)O)O	CC1C(C(CC(O1)OC2C(OC(CC2O)OC3C(OC(CC3O)OC4CCC5(C(C4)CCC6C5CC(C7(C6(CCC7C8CC(=O)OC8)O)C)O)C)C)C)O)O	reduction
DM4	Eltrombopag	SB-611855	CC1=C(C=C(C=C1)N2C(=O)C(=C(N2)C)NN=C3C=CC=C(C3=O)C4=CC(=CC=C4)C(=O)O)C	C1=CC(=CC(=C1)C(=O)O)C2=C(C(=CC=C2)N)O	reduction
DM5	Indicine N-oxide	Indicine	CC(C)C(C(C)O)(C(=O)OCC1=CC[N+]2(C1C(CC2)O)[O-])O	CC(C)C(C(C)O)(C(=O)OCC1=CCN2C1C(CC2)O)O	reduction
DM6	Levamisole	Levametabol I	C1CSC2=NC(CN21)C3=CC=CC=C3	C1C(N(C(=O)N1CCS)O)C2=CC=CC=C2	reduction
DM7	Loperamide N-oxide	loperamide	CN(C)C(=O)C(CC[N+]1(CCC(CC1)(C2=CC=C(C=C2)Cl)O)[O-])(C3=CC=CC=C3)C4=CC=CC=C4	CN(C)C(=O)C(CCN1CCC(CC1)(C2=CC=C(C=C2)Cl)O)(C3=CC=CC=C3)C4=CC=CC=C4	reduction
DM8	Lovastatin	lovastatin acid	CCC(C)C(=O)OC1CC(C=C2C1C(C(C=C2)C)CCC3CC(CC(=O)O3)O)C	CCC(C)C(=O)OC1CC(C=C2C1C(C(C=C2)C)CCC(CC(CC(=O)O)O)O)C	reduction
DM9	Neoprontosil	sulphanilamide	CC(=O)NC1=C(C=C2C=C(C(=NNC3=CC=C(C=C3)S(=O)(=O)N)C(=O)C2=C1)S(=O)(=O)O)S(=O)(=O)O	C1=CC(=CC=C1N)S(=O)(=O)N	reduction
DM10	Nitrazepam	7-aminonitrazepam	C1C(=O)NC2=C(C=C(C=C2)[N+](=O)[O-])C(=N1)C3=CC=CC=C3	C1C(=O)NC2=C(C=C(C=C2)N)C(=N1)C3=CC=CC=C3	reduction
DM11	Potassium oxonate	5-azauracil (5-AZU)	C1(=NC(=O)NC(=O)N1)C(=O)[O-].[K+]	C1=NC(=O)NC(=O)N1	reduction
DM12	Prontosil	sulphanilamide	C1=CC(=CC=C1N=NC2=C(C=C(C=C2)N)N)S(=O)(=O)N	C1=CC(=CC=C1N)S(=O)(=O)N	reduction
DM13	Risperidone	9-OH-RIS	CC1=C(C(=O)N2CCCCC2=N1)CCN3CCC(CC3)C4=NOC5=C4C=CC(=C5)F	CC1=C(C(=O)N2CCCC(C2=N1)O)CCN3CCC(CC3)C4=NOC5=C4C=CC(=C5)F	reduction
DM14	SN-38G	SN-38	CCC1=C2C=C(C=CC2=NC3=C1CN4C3=CC5=C(C4=O)COC(=O)C5(CC)O)OC6C(C(C(C(O6)C(=O)O)O)O)O	CCC1=C2C=C(C=CC2=NC3=C1CN4C3=CC5=C(C4=O)COC(=O)C5(CC)O)O	hydrolysis
DM15	Sodium picosulfate	4,4'-dihydroxydiphenyl-(2 pyridyl)-methane	C1=CC=NC(=C1)C(C2=CC=C(C=C2)OS(=O)(=O)[O-])C3=CC=C(C=C3)OS(=O)(=O)[O-].[Na+].[Na+]	C1=CC=C(C(=C1)CC2=CC=C(C=C2)O)O	hydrolysis
DM16	Sorivudine	E-5-(2-bromovinyl)uracil	C1=C(C(=O)NC(=O)N1C2C(C(C(O2)CO)O)O)C=CBr	C1=CC=C2C(=C1)C3C(=NC(=N3)C4=CC=C(C=C4)F)C5=CC=CC=C25	hydrolysis
DM17	Sulfinpyrazone	Sulfinpyrazone sulfide	C1=CC=C(C=C1)N2C(=O)C(C(=O)N2C3=CC=CC=C3)CCS(=O)C4=CC=CC=C4	C1=CC=C(C=C1)N2C(=O)C(C(=O)N2C3=CC=CC=C3)CCSC4=CC=CC=C4	reduction
DM18	Zonisamide	2-Sulfamoylacetylphenol	C1=CC=C2C(=C1)C(=NO2)CS(=O)(=O)N	C1=CC=C(C(=C1)C(=O)CS(=O)(=O)N)O	reduction
DM19	Levodopa	m-hydroxyphenylacetic acid	C1=CC(=C(C=C1CC(C(=O)O)N)O)O	C1=CC(=CC(=C1)O)CC(=O)O	reduction
DM20	Levodopa	m-tyramine	C1=CC(=C(C=C1CC(C(=O)O)N)O)O	C1=CC(=CC(=C1)O)CCN	reduction
DM21	Metronidazole	N-(2-hydroxyethyl)-oxamic acid	CC1=NC=C(N1CCO)[N+](=O)[O-]	C(CO)NC(=O)C(=O)O	reduction
DM22	Methotrexate	4-amino-4-deoxy-N10-methylpteroic acid	CN(CC1=CN=C2C(=N1)C(=NC(=N2)N)N)C3=CC=C(C=C3)C(=O)NC(CCC(=O)O)C(=O)O	CN(CC1=CN=C2C(=N1)C(=NC(=N2)N)N)C3=CC=C(C=C3)C(=O)O	hydrolysis
DM23	Diclofenac glucuronide	diclofenac	C1=CC=C(C(=C1)CC(=O)OC2C(C(C(C(O2)C(=O)O)O)O)O)NC3=C(C=CC=C3Cl)Cl	C1=CC=C(C(=C1)CC(=O)O)NC2=C(C=CC=C2Cl)Cl	hydrolysis