<html xmlns:v="urn:schemas-microsoft-com:vml" xmlns:o="urn:schemas-microsoft-com:office:office" xmlns:w="urn:schemas-microsoft-com:office:word" xmlns:m="http://schemas.microsoft.com/office/2004/12/omml" xmlns="http://www.w3.org/TR/REC-html40"><head><meta http-equiv=Content-Type content="text/html; charset=us-ascii"><meta name=Generator content="Microsoft Word 12 (filtered medium)"><style><!--
/* Font Definitions */
@font-face
{font-family:"Cambria Math";
panose-1:2 4 5 3 5 4 6 3 2 4;}
@font-face
{font-family:Calibri;
panose-1:2 15 5 2 2 2 4 3 2 4;}
/* Style Definitions */
p.MsoNormal, li.MsoNormal, div.MsoNormal
{margin:0in;
margin-bottom:.0001pt;
font-size:11.0pt;
font-family:"Calibri","sans-serif";}
a:link, span.MsoHyperlink
{mso-style-priority:99;
color:blue;
text-decoration:underline;}
a:visited, span.MsoHyperlinkFollowed
{mso-style-priority:99;
color:purple;
text-decoration:underline;}
span.EmailStyle17
{mso-style-type:personal-compose;
font-family:"Calibri","sans-serif";
color:windowtext;}
.MsoChpDefault
{mso-style-type:export-only;}
@page WordSection1
{size:8.5in 11.0in;
margin:1.0in 1.0in 1.0in 1.0in;}
div.WordSection1
{page:WordSection1;}
--></style><!--[if gte mso 9]><xml>
<o:shapedefaults v:ext="edit" spidmax="1026" />
</xml><![endif]--><!--[if gte mso 9]><xml>
<o:shapelayout v:ext="edit">
<o:idmap v:ext="edit" data="1" />
</o:shapelayout></xml><![endif]--></head><body lang=EN-US link=blue vlink=purple><div class=WordSection1><p class=MsoNormal><b><span style='font-size:12.0pt;color:#943634'>>> Simbios Research Highlight <o:p></o:p></span></b></p><p class=MsoNormal><b><span style='color:#548DD4'><o:p> </o:p></span></b></p><p class=MsoNormal><span style='color:#943634'><a href="http://www.cell.com/biophysj/retrieve/pii/S0006349511013282"><span style='color:#943634'>Optimized Torsion-Angle Normal Modes Reproduce Conformational Change More Accurately Than Cartesian Modes</span></a><o:p></o:p></span></p><p class=MsoNormal><i><span style='font-size:10.0pt'>Biophysical Journal, Dec 2012, 101(12):2966-2969<span style='color:#943634'><o:p></o:p></span></span></i></p><p class=MsoNormal><o:p> </o:p></p><p class=MsoNormal><span style='font-size:10.0pt'>Simbios postdoctoral fellow Jenelle Bray uses normal modes, which are less computationally intensive than molecular dynamics, to study protein conformational changes. She has developed an optimized torsion angle version that is more accurate than computing the modes in Cartesian coordinates. Learn more about normal modes and its applications in our latest video posted at <a href="http://simbios.stanford.edu">http://simbios.stanford.edu</a>. <o:p></o:p></span></p><p class=MsoNormal><span style='font-size:10.0pt;color:#C0504D'><o:p> </o:p></span></p><p class=MsoNormal><b><u><span style='font-size:12.0pt;color:#943634'><o:p><span style='text-decoration:none'> </span></o:p></span></u></b></p><p class=MsoNormal><b><span style='font-size:12.0pt;color:#943634'>>> Simbios News<o:p></o:p></span></b></p><p class=MsoNormal><span style='color:#C0504D'><o:p> </o:p></span></p><p class=MsoNormal><span style='color:#943634'><a href="https://simtk.org/project/xml/news.xml?group_id=161"><span style='color:#943634'>OpenMM 4.1 Released </span></a><o:p></o:p></span></p><p class=MsoNormal><span style='font-size:10.0pt'><a href="http://simtk.org/home/openmm">OpenMM</a> is both a software library and application for molecular dynamics simulations on high-performance computer architectures, such as GPUs. Highlighted features from this latest release include model building tools, custom integrators, and the ability to add virtual sites. </span><span style='color:#C0504D'><o:p></o:p></span></p><p class=MsoNormal><b><span style='font-size:12.0pt;color:#943634'><o:p> </o:p></span></b></p><p class=MsoNormal style='text-autospace:none'><span style='color:#943634'><a href="http://simbios.stanford.edu/PressReleases/2012apr_opensim.htm"><span style='color:#943634'>OpenSim, NASA Help Launch Eighth-Grade Science Project </span></a><o:p></o:p></span></p><p class=MsoNormal style='text-autospace:none'><span style='font-size:10.0pt'>A science fair project using <a href="http://simtk.org/home/opensim">OpenSim</a> to study the effects of microgravity on exercising astronauts wins awards and is accepted for presentation at this summer’s ASME bioengineering meeting.<o:p></o:p></span></p><p class=MsoNormal style='text-autospace:none'><span style='font-size:10.0pt'><o:p> </o:p></span></p><p class=MsoNormal><b><span style='font-size:12.0pt;color:#943634'><o:p> </o:p></span></b></p><p class=MsoNormal><b><span style='font-size:12.0pt;color:#943634'>>> Upcoming Events and Opportunities <o:p></o:p></span></b></p><p class=MsoNormal><o:p> </o:p></p><p class=MsoNormal><span style='color:#943634'><a href="http://opensim.stanford.edu/support/event_details.html?id=43&title=OpenSim-Advanced-User-Workshop"><span style='color:#943634'>OpenSim Advanced User Workshop </span></a><o:p></o:p></span></p><p class=MsoNormal><span style='font-size:10.0pt'>August 22-24, 2012; Stanford University, Stanford, California<o:p></o:p></span></p><p class=MsoNormal><span style='font-size:10.0pt'>Application Deadline: June 1, 2012<o:p></o:p></span></p><p class=MsoNormal><o:p> </o:p></p><p class=MsoNormal><span style='color:#943634'>Rapid Molecular Dynamics Simulations and Prototyping Workshop:<o:p></o:p></span></p><p class=MsoNormal><span style='color:#943634'>An Intro to the OpenMM Application<o:p></o:p></span></p><p class=MsoNormal><span style='font-size:10.0pt'>September 6-7, 2012; Stanford University, Stanford, California<o:p></o:p></span></p><p class=MsoNormal><span style='font-size:10.0pt'>Email <a href="mailto:simbiosfeedback@stanford.edu">simbiosfeedback@stanford.edu</a> for more information<o:p></o:p></span></p><p class=MsoNormal><span style='font-size:10.0pt'><o:p> </o:p></span></p><p class=MsoNormal><i><span style='font-size:10.0pt;color:#595959'>_______________________________________________<o:p></o:p></span></i></p><p class=MsoNormal><i><span style='font-size:10.0pt;color:#595959'><o:p> </o:p></span></i></p><p class=MsoNormal><i><span style='font-size:10.0pt;color:#595959'>Joy P. Ku, PhD<o:p></o:p></span></i></p><p class=MsoNormal><i><span style='font-size:10.0pt;color:#595959'>Director, Simbios<o:p></o:p></span></i></p><p class=MsoNormal><a href="http://simbios.stanford.edu"><i><span style='font-size:10.0pt'>http://simbios.stanford.edu</span></i></a><i><span style='font-size:10.0pt;color:#595959'><o:p></o:p></span></i></p><p class=MsoNormal><i><span style='font-size:10.0pt;color:#595959'><o:p> </o:p></span></i></p><p class=MsoNormal><i><span style='font-size:10.0pt;color:#595959'>Director of Communications & Training,<o:p></o:p></span></i></p><p class=MsoNormal><i><span style='font-size:10.0pt;color:#595959'>National Center for Simulation in Rehabilitation Research<o:p></o:p></span></i></p><p class=MsoNormal><a href="http://opensim.stanford.edu"><i><span style='font-size:10.0pt'>http://opensim.stanford.edu</span></i></a><i><span style='font-size:10.0pt;color:#595959'><o:p></o:p></span></i></p><p class=MsoNormal><i><span style='font-size:10.0pt;color:#595959'><o:p> </o:p></span></i></p><p class=MsoNormal><i><span style='font-size:10.0pt;color:#595959'>(W) 650.736.8434, (F) 650.723.7461<o:p></o:p></span></i></p><p class=MsoNormal><i><span style='font-size:10.0pt;color:#595959'>Email: </span></i><a href="mailto:joyku@stanford.edu"><i><span style='font-size:10.0pt'>joyku@stanford.edu</span></i></a><i><span style='font-size:10.0pt;color:#595959'><o:p></o:p></span></i></p><p class=MsoNormal><o:p> </o:p></p><p class=MsoNormal><o:p> </o:p></p><p class=MsoNormal><o:p> </o:p></p></div></body></html>