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<span style="font-family: Arial; font-size: medium; ">Population Modeling Working Group members:</span></div>
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<div><span style="color: rgb(0, 0, 0); font-family: Arial; font-size: medium; ">We believe that some of our work is </span>relevant to the field. </div>
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Phenomena that characterize many health-influencing interventions exhibit considerable intra- and interindividual variability. We are early on a M&S methodology path intended to provide mechanistic explanations that can be tailored to individual patients.
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We utilize non-reductionist agent-oriented methods. Mechanisms within our models are parsimonious and thus relatively coarse grain. </div>
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A recent paper explaining the need for such methods: </div>
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<a href="http://onlinelibrary.wiley.com/doi/10.1002/wsbm.1222/full">http://onlinelibrary.wiley.com/doi/10.1002/wsbm.1222/full</a></div>
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Active projects: </div>
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1) Considerable intra-individual variability is observed for some individuals but not others in bioavailability of generic drug products. Why? </div>
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Recent paper: </div>
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<a href="http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0108392">http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0108392</a></div>
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2) There is considerable intra- and interindividual variability in phenomena resulting from drug induced liver injury. Why?</div>
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Recent paper: </div>
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<a href="http://biosystems.ucsf.edu/publications/FinalSSCManuscript15May14authCopy.pdf">http://biosystems.ucsf.edu/publications/FinalSSCManuscript15May14authCopy.pdf</a></div>
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3) There is considerable interindividual variability in fracture healing, especially the occurrence of fracture non-unions. Why?</div>
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This project is earlier stage.</div>
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4) Answering that above questions requires that analog mechanisms are modular. </div>
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Recent paper: </div>
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<a href="http://www.biomedcentral.com/1752-0509/8/95/abstract">http://www.biomedcentral.com/1752-0509/8/95/abstract</a></div>
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Other publications: <a href="http://biosystems.ucsf.edu/publications.html">http://biosystems.ucsf.edu/publications.html</a> </div>
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Commentary and questions welcomed. </div>
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Regards</div>
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-Tony-</div>
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