This is the wiki site for Predicting Cell Deformation from Body Level Mechanical Loads. Our research efforts are funded by the National Institute of Biomedical Imaging and Engineering (NIBIB) of the National Institutes of Health (NIH). The proposed research was in response to Predictive Multiscale Models of the Physiome in Health and Disease (MSM Physiome) Initiative. The project is part of the Interagency Modeling and Analysis Group (IMAG) (see IMAG website and IMAG wiki) and the Multi-Scale Modeling (MSM) Initiative (see MSM website). More details are available in GrantInformation.

If you are a new member (How do I become a member?), please read the following documentation to familiarize yourself with operational details:

For recent activity of team members, always check RecentChanges.

Project Goals

  1. To develop computational models of the knee joint at multiple resolutions (joint, tissue, and cell).
  2. To obtain cell deformations in cartilage, ligaments and menisci for given states of knee loading.
  3. To validate multiscale knee simulations for cell and tissue deformations, and joint movements.

To meet these goals, a battery of experiments and various multiscale computational modeling and simulations will be performed. Full grant proposal can be found in GrantInformation.


A list of team members can be found here.


Please note that all those subprojects are rather involved and will likely have smaller projects associated with them. Check the individual pages frequently for overall progress in these areas.

Conference Calls

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