## Please edit system and help pages ONLY in the moinmaster wiki! For more ## information, please see MoinMaster:MoinPagesEditorGroup. ##master-page:FrontPage #format wiki #language en #pragma section-numbers off ## Below provides read access to public #acl +All:read Default This is the development site of Operation MULTiS - ''Reference Models for Multi-Layer Tissue Structures''. The development efforts for this project have been organized by Ahmet Erdemir and supported by !CoBi Core, !BioRobotics Testing Core, the Multidisciplinary Simulation Center of the Cleveland Clinic, and Simbios of the Stanford University. ''This research and development project titled “Reference Models for Multi-Layer Tissue Structures" was conducted by the Cleveland Clinic Foundation and was made possible by a contract vehicle which was awarded and administered by the U.S. Army Medical Research & Materiel Command under award number: W81XWH-15-1-0232. The views, opinions and/or findings contained in this website are those of the authors and do not necessarily reflect the views of the Department of Defense and should not be construed as an official DoD/Army position, policy or decision unless so designated by other documentation. No official endorsement should be made.'' <> = Grant Information = [[attachment:proposal.pdf]] = Visibility & Outreach = == Journal Articles == Published articles * Schimmoeller T, Cho KH, Colbrunn R, Nagle T, Neumann E, Erdemir A. '''Instrumentation of Surgical Tools To Measure Load and Position During Incision, Tissue Retraction, and Suturing.''' ''Conf Proc IEEE Eng Med Biol Soc.'' 2018 Jul;2018:933-936. doi: 10.1109/EMBC.2018.8512332. PMID: 30440543 . [[https://ieeexplore.ieee.org/document/8512332|Manuscript]] * Neumann EE, Owings TM, Schimmoeller T, Nagle TF, Colbrunn RW, Landis B, Jelovsek JE, Wong M, Ku JP, Erdemir A. '''Reference data on thickness and mechanics of tissue layers and anthropometry of musculoskeletal extremities.''' ''Sci Data.'' 2018 Sep 25;5:180193. doi: 10.1038/sdata.2018.193. PMID: 30251995 . [[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6154283/|Manuscript]] * Schimmoeller T, Colbrunn R, Nagle T, Lobosky M, Neumann EE, Owings TM, Landis B, Jelovsek JE, Erdemir A. '''Instrumentation of Off-The-Shelf Ultrasound System for Measurement of Probe Forces During Freehand Imaging.''' ''J Biomech.'' 2019, 83:117-124. doi: 10.1016/j.jbiomech.2018.11.032. PMID: 30514629 . [[https://www.sciencedirect.com/science/article/pii/S0021929018308674?via=ihub|Manuscript]] * Neumann EE, Owings TM, Erdemir A: '''Regional variations of in vivo surface stiffness of soft tissue layers of musculoskeletal extremities.''' ''J Biomech.'' (Epub ahead of print). . [[https://www.sciencedirect.com/science/article/pii/S0021929019305135?via%3Dihub|Manuscript]] * Schimmoeller T, Neumann E, Owings T, Nagle T, Colbrunn R, Landis B, Jelovsek JE, Hing T, Ku J, Erdemir A: '''Reference data on in vitro anatomy and mechanics of tissue layers of musculoskeletal extremities.''' ''Sci Data.'' (in review). * Schimmoeller T, Neumann E, Nagle T, Erdemir A: '''Reference tool kinematics-kinetics and tissue surface strain data during fundamental surgical acts.''' ''Sci Data.'' (in review). See [[articles being planned/drafted|list of articles]] being planned/drafted. == Conferences == See [[Conferences]] where portions of this project have been presented. = Roadmap = The overall goal of this study is to establish the founding knowledge, data and models for the mechanics of multi-layer tissue structures of the limbs, particularly of the lower and upper legs and arms. By delivering this lacking information, the activity will promote scientific research in layered tissue structures and allow reliable virtual surgery simulations for clinical training and certification. Below is a list of project milestones, which correspond to the specific objectives of the project. '''Project Duration.''' September 1, 2015 - August 31, 2018 Each milestone (or a task within a milestone) is staged to assist a Go / No Go type of decision process: * ''Readiness of infrastructure.'' Are all necessary resources to accomplish the task available? * ''Readiness of specifications (standard operating procedures).'' Are the specifications of the task detailed enough to follow through? * ''Mock up runs.'' Is there a need to update specifications to respond to unforeseen issues? * ''Execution of specifications.'' Do the resultant outcomes of specifications match desired deliverables of the task? * ''Dissemination of deliverables.'' Are deliverables shared within the project team and with the community to feed into follow up tasks? == Milestones == ||'''YEAR 1''' ||Web-based interfaces for data curation, queryable data and model databases. || ||'''YEAR 1''' ||In vivo multi-layer tissue anatomy and indentation mechanics. || ||'''YEARS 1-2''' ||In vitro multi-layer tissue anatomy, mechanical properties, and indentation mechanics. || ||'''YEAR 2''' ||In vitro quantification of tool forces during surgery of multi-layer tissue structures. || ||'''YEAR 2''' ||Physiologically realistic, fully specimen-specific, nonlinear reference models. || ||'''YEAR 2''' ||Physiologically realistic, partially subject-specific, nonlinear reference models. || ||'''YEAR 3''' ||Computationally efficient surrogate models for multi-layer tissue structures. || ||'''YEAR 3''' ||Demonstration of efficient surrogate models of multi-layer tissue structures. || ||'''YEARS 1-3''' ||Population and dissemination of data and models. || == Roadmap for web based interfaces == * ''Readiness of infrastructure.'' * Initial prototypes * ''Readiness of specifications.'' see [[Specifications/DataManagement]] * Completion of specifications and identification of infrastructure * ''Mock up runs.'' * Completion of prototype evaluation * ''Execution of specifications.'' * ''Dissemination of deliverables.'' * Beta, gamma, and delta were released for in vivo, in vitro, and surgical tools data, respectively. == Roadmap for in vivo testing == * ''Readiness of infrastructure.'' see [[Infrastructure/InstrumentedUltrasound]] * ''Readiness of specifications.'' see [[Specifications/InVivoTesting]] * ''Mock up runs.'' see [[Specifications/InVivoTesting/Discussion]] * ''Execution of specifications.'' see [[Subjects]] * ''Dissemination of deliverables.'' see [[Licensing]] for terms of use and distribution of data * Dynamic Data Managment Site: https://multisbeta.stanford.edu/ * Static DOI: https://www.doi.org/10.18735/S5R97F == Roadmap for in vitro testing (ultrasound indentation) == * ''Readiness of infrastructure.'' see [[Infrastructure/InstrumentedUltrasound]], [[Infrastructure/TestingRoom]] & [[Infrastructure/Imaging]] * ''Readiness of specifications.'' see [[Specifications/InVitroTesting]] * Completion of specifications for indentation * Completion of specifications for anatomical imaging * Completion of specifications for tissue testing * Completion of specifications for development of testing platform * ''Mock up runs.'' * ''Execution of specifications.'' see InVitroExperiments * Start of experiments * ''Dissemination of deliverables.'' * Dynamic Data Managment Site: https://multisgamma.stanford.edu/ == Roadmap for in vitro testing (surgical tools) == * ''Readiness of infrastructure.'' see [[Infrastructure/InstrumentedSurgicalTools]], [[Infrastructure/TestingRoom]] & [[Infrastructure/Imaging]] * Initial prototype for surgical tool - force transducer integration * ''Readiness of specifications.'' see [[Specifications/InVitroTesting]] * Completion of specifications for surgical manipulation * Completion of specifications for spatial strain measurement and digital video recording * ''Mock up runs.'' * ''Execution of specifications.'' see InstToolsExperiments * Start of experiments * ''Dissemination of deliverables.'' * Dynamic Data Managment Site: https://multisdelta.stanford.edu/ == Roadmap for reference models (in vitro) == * ''Readiness of infrastructure.'' * ''Readiness of specifications.'' see [[Specifications/IndentationModeling|IndentationModeling]] * ''Mock up runs.'' * ''Execution of specifications.'' * ''Dissemination of deliverables.'' == Roadmap for reference models (in vivo) == * ''Readiness of infrastructure.'' * ''Readiness of specifications.'' see [[Specifications/IndentationModeling|IndentationModeling]] * ''Mock up runs.'' * ''Execution of specifications.'' * ''Dissemination of deliverables.'' == Roadmap for surrogate models == * ''Readiness of infrastructure.'' * ''Readiness of specifications.'' see [[Specifications/IndentationModeling|IndentationModeling]] and [[Specifications/SofaBasics|SofaBasics]] * ''Mock up runs.'' * ''Execution of specifications.'' * ''Dissemination of deliverables.'' == Roadmap for demonstration == * ''Readiness of infrastructure.'' * ''Readiness of specifications.'' * ''Mock up runs.'' * ''Execution of specifications.'' * ''Dissemination of deliverables.'' = Specifications = * [[Specifications/InVivoTesting|In Vivo Testing]] * [[Specifications/InVitroTesting|In Vitro Testing]] * [[Specifications/Specimen|Specimen Specifications]] * [[Specifications/SpecimenPreparation|Specimen Preparation]] * [[Specifications/Labeling|Labeling Conventions]] * [[Specifications/Imaging|CT and MRI Specifications]] * [[InVitroExperiments|Experiment Notes]] * [[Specifications/InstrumentedSurgicalTools|Instrumented Surgical Tools]] * [[InstToolsExperiments|Experiment Notes]] * [[Specifications/ExperimentationTissueMechanics|Tissue Testing Protocol]] * [[Specifications/TissueMechanicsRepeatability|Tissue Testing Repeatability]] * [[Specifications/DataManagement|DataManagement]] * [[Specifications/DataManagement/GettingStarted|GettingStarted]] * [[Specifications/DataAnalysis|DataAnalysis]] * [[Specifications/DataAnalysis/FileAssociation|FileAssociation]] * [[Specifications/DataAnalysis/QualityAssurance|QualityAssurance]] * [[Specifications/DataAnalysis/ThicknessAnalysis|ThicknessAnalysis]] * [[Specifications/DataAnalysis/Registration|Registration]] * [[Specifications/DataAnalysis/ReportGeneration|ReportGeneration]] * [[Specifications/ModelDevelopment|Model Development]] * [[Specifications/ModelingPriorities|Modeling Priorities]] * [[Specifications/ImageSegmentation|ImageSegmentation]] * [[Specifications/GeometryGeneration|GeometryGeneration]] * [[Specifications/GeometryMorphing|GeometryMorphing]] * [[Specifications/MeshGeneration|MeshGeneration]] * [[Specifications/ModelAssembly|ModelAssembly]] * [[Specifications/IndentationModeling|IndentationModeling]] * [[Specifications/FullySpecificModeling|FullySpecificModeling]] * [[Specifications/SofaBasics|SofaBasics]] * [[Specifications/FebioTestSuite|FebioTestSuite]] * [[Specifications/MeshConvergence|MeshConvergence]] * [[Specifications/FebioElementComparison|FebioElementComparison]] * [[Specifications/LayeredModelDevelopment1|LayeredModelDevelopment1]] * [[Specifications/LayeredModelDevelopment2|LayeredModelDevelopment2]] * [[Specifications/LayeredModelsJointSmoothing|LayeredModelsJointSmoothing]] = Infrastructure = * [[Infrastructure/TestingRoom|TestingRoom]] * [[Infrastructure/ImagingFixture|ImagingFixture]] * [[Infrastructure/InstrumentedUltrasound|InstrumentedUltrasound]] * [[Infrastructure/InstrumentedSurgicalTools|InstrumentedSurgicalTools]] * [[Infrastructure/Imaging|Imaging]] * [[Infrastructure/TissueCharacterization|TissueCharacterization]] * [[Infrastructure/SpatialStrainMeasurement|SpatialStrainMeasurement]] * [[Infrastructure/DigitalVideo|DigitalVideo]] * [[Infrastructure/HapticInterfaces|HapticInterfaces]] * [[Infrastructure/SimulationSoftware|SimulationSoftware]] * [[Infrastructure/DataManagement|DataManagementSite]] * [[Infrastructure/AuxiliarySoftware|AuxiliarySoftware]] = Recurring Meetings = * see minutes for [[RecurringMeetings|Recurring Meetings]]