Recurring Meeting of Cleveland Clinic Core Team

Date: Nov 5, 2013

Time: 10:30 AM EST

Means: In person meeting

Attendees:

1. Ahmet Erdemir
2. Jason Halloran
3. Snehal Chokhandre
4. Robb Colbrunn
5. Tara Bonner

Agenda:

1. Discuss tasks progress.(Finalize specimen specification to order specimens). 2. Discuss/finalize tissue testing equipment purchase. 3. Decide tasks for the next meeting. 4. Other

Notes:

1. Discuss task progress.
   • Specimen specifications and ordering
     • Team needs to deliberate on the need for ordering specimens that include pelvis to toes (registration issues, increased testing time, freeze thaw cycles, sharing/exchange with other groups etc.)
     • For immediate needs, 2 specimens (different donors) will be ordered with the current specifications (hip to toes).
     • Team will add and update as discussion points the secondary specimens and primary specimen specifications with additional requirements.
     • Access to specimens will all lower extremity joints (specimen specific) and the knowledge of specimen preparation and testing, and model development (from the knee joints), we may be able to extend. branch off to modeling specimen specific entire lower extremity (hip, knee and ankle joints).
     • x-ray imaging will need to be done with axial load on the joint.
   • Imaging specifications
     • The current protocol will be used as a starting point.
     • Specimen transportation jig needs to be designed (to hold the specimen in neutral position and applying tension on patella, without disturbing the registration markers while transporting the specimen from Clinic to Case imaging facility).
     • The design of fixture will be included in specimen preparation for MRI.
     • A test session will be conducted on Nov. 14th to test/ analyse the current protocol and check the artefacts related to the brass registration system. Other material samples will also be tested in this session.
     • Current protocol will be used to test and modify the setting based on which tissues we are interested in and the ease of automating segmentation. (T1 for ligaments, tendons and meniscus and T2 for cartilage)
   • Specimen preparation
     • Target outcomes were clearly defined by Ahmet.
     • The page is divided in sections for different preparation stages (imaging, joint testing etc).
     • Preparation for registration is divided into initialisation (anatomical coordinate system to optotrak) and registration preparation (image to joint coordinate system).
   • Registration specifications

2.

3.

4. Other