Recurring Meeting of Cleveland Clinic Core Team

Date: December 10, 2013

Time: 10:30 AM EST

Means: In person meeting

Attendees:

1. Ahmet Erdemir
2. Jason Halloran
3. Craig Bennetts
4. Snehal Chokhandre
5. Robb Colbrunn
6. Tara Bonner

Agenda:

1. Discuss tasks progress.
2. Discuss specimen transportation device design and options.
3. Discuss preparations for Martin Garon's visit next week.
4. Decide tasks for the next meeting.
5. Other

Immediate action items:

• Craig and Snehal

  • Contact machine shop to get pvc and foam pieces machined for specimen transportation device. Also get quotes.

  Jason, Snehal and Craig

  • Get a transportation device prototype made and set up an imaging session at UH.

  Snehal

  • Get more information about the 75 yr old cadaveric knee (hip to toe, price).
  • Contact Dr. Winalski and Dr. Morgan to assess the xrays (frozen and without axial compression) and ask about effects of prolonged smoking on cartilage quality.
  • Reschedule CCF-Univ of Utah meeting.
  • Prepare samples and clamps etc for Biomomentum demo.

  Jason and Snehal

  • Check whether the coordinate system for the MRI machine remains consistent between scans (for the same unmoved specimen).

• Robb

  • Request quotes from Biomomentum.

  Craig, Snehal and Tara

  • Check sample material (to replace brass marker components) compatibility with bone cement.

  All

  • Read specimen preparation and registration pages and make necessary edits.
  • Review and the data structure document updated by Robb in Experimentation infrastructure.

  Jason

  • Contact Tekscan (triggers and automation, manual control specifications,sensors).

Notes:

1. Discuss task progress
   • Immediate action items were discussed.
     • Snehal sent the machine configurations to Robb.
     • Craig got the pvc and foam samples.
     • Ahmet reviewed and edited the specimen preparation and registration pages.
     • Robb and Jason edited the joint testing specifications.
     • Snehal obtained a tendon sample and tested whether it can be cut with a cryostat.
   • Specimen specifications

     • ScienceCare sent information regarding three potential specimens.

     • Xrays of frozen specimens were provided.
     • Two of the specimens did not meet the age and weight criteria and the third specimen was deemed unusable after lab tests.
     • Xrays with axial loads are requested on fresh specimens in the future.
     • Need to check effects of smoking on the tissue health (cartilage in particular).
     • Snehal will check with Robb and Tara whether any other knee specimens will be available to swap if both left and right knees were ordered for a donor.
   • Cloud computing prototype specifications
     • Craig will provide a results retrieval interface prototype design.
     • Ahmet will prepare a similar interface prototype for admin panel (will be similar to user interface with additional privileges).
   • Imaging specifications
     • UH engineers are working on programming the 3d DESS and MESE protocols.
     • Once they are ready, the previously used knee specimen will be imaged using these protocols.
     • The different materials potentially used to replace the brass marker components will also be imaged to check for any artefacts.
     • A prototype for the specimen transportation device will be built before the next imaging session.
     • Need to check whether the image coordinate system remains unchanged (theoretically, it should), if the specimen is not moved between scans.
     • Ahmet suggested the team members look at the data available at OAI (Imaging data for numerous subjects is freely available)
     • The group will meet in the future to discuss the potential utility of the available database in our research.
     • A data organization/ logistical pathway used by OAI can provide useful guidelines for Open Knee data organization/ dissemination.
     • The material samples will be tested for compatibility with bone cement.
   • Joint testing specifications
     • Robb added the data structure information on experimentation infrastructure page.