Recurring Meeting of Cleveland Clinic Core Team

Date: December 10, 2013

Time: 10:30 AM EST

Means: In person meeting

Attendees:

1. Ahmet Erdemir
2. Jason Halloran
3. Craig Bennetts
4. Snehal Chokhandre
5. Robb Colbrunn
6. Tara Bonner

Agenda:

1. Discuss tasks progress.
2. Discuss specimen transportation device design and options.
3. Discuss preparations for Martin Garon's visit next week.
4. Decide tasks for the next meeting.
5. Other.

Immediate Action Items:

See notes for details.

• Snehal

  • Get more information about candidate knee specimen, 75 years old donor (hip to toe, price).
  • Contact Dr. Winalski and Dr. Morgan to assess the X-rays of candidate specimens acquired at a frozen state without axial compression, and ask about effects of prolonged smoking on cartilage quality.
  • Reschedule Cleveland Clinic - University of Utah conference call.
  • Prepare samples, clamps, etc. for Biomomentum, Inc. demo.

• Robb

  • Request quotes from Biomomentum, Inc.

• Jason

  • Contact Tekscan (to ask about triggers and automation, manual control specifications,sensors).

• Craig and Snehal

  • Contact machine shop to get PVC and foam pieces machined for specimen transportation device. Also get quotes.

• Jason and Snehal

  • Check whether the coordinate system for the MRI machine remains consistent between scans (for the same stationary specimen).

• Jason, Snehal and Craig

  • Get a transportation device prototype made and set up an imaging session at the University Hospitals.

• Craig, Snehal and Tara

  • Check the compatibility of sample materials (to replace brass marker components) with bone cement.

• All

  • Read specimen preparation and registration pages and make necessary edits.
  • Review the data structure document updated by Robb in the wiki pages of experimentation infrastructure.

Notes:

1. Discuss task progress.
   • Immediate action items were discussed.
     • Snehal sent the machine configurations to Robb.
     • Craig got the pvc and foam samples.
     • Ahmet reviewed and edited the specimen preparation and registration pages.
     • Robb and Jason edited the joint testing specifications.
     • Snehal obtained a tendon sample and successfully tested cutting it with a cryostat.
   • Specimen specifications.

     • ScienceCare sent information regarding three potential specimens.

     • Xrays of frozen specimens were provided.
     • Two of the specimens did not meet the age and weight criteria and the third specimen was deemed unusable after lab tests.
     • Xrays with axial loads are requested on fresh specimens in the future.
     • Need to check effects of smoking on the tissue health (cartilage in particular).
     • Snehal will check with Robb and Tara whether any other knee specimens will be available to swap if both left and right knees were ordered for a donor.
   • Cloud computing prototype specifications.
     • Craig will provide a results retrieval interface prototype design.
     • Ahmet will prepare a similar interface prototype for admin panel (will be similar to user interface with additional privileges).
   • Imaging specifications.
     • UH engineers are working on programming the 3d DESS and MESE protocols.
     • Once they are ready, the previously used knee specimen will be imaged using these protocols.
     • The different materials potentially used to replace the brass marker components will also be imaged to check for any artefacts.
     • A prototype for the specimen transportation device will be built before the next imaging session.
     • Need to check whether the image coordinate system remains unchanged (theoretically, it should), if the specimen is not moved between scans.
     • Ahmet suggested the team members look at the data available at OAI (Imaging data for numerous subjects is freely available)
     • The group will meet in the future to discuss the potential utility of the available database in our research.
     • A data organization/ logistical pathway used by OAI can provide useful guidelines for Open Knee data organization/ dissemination.
     • The material samples will be tested for compatibility with bone cement.
   • Joint testing specifications.
     • Tibiofemoral joint testing
       • Robb added a detailed data structure information document on experimentation infrastructure page.
     • Patellofemoral joint testing
       • Robb and Tara will update the tendon clamp preparation information in patellofemoral joint testing.
       • Jason addressed Ahmet's queries in the patellofemoral joint testing operating procedure.
       • The discussion will be written up as a description.
       • Testing timeline was modified by Jason.
       • At 20N quadriceps load, need to verify the patellofemoral contact patches are centered on the sensor. Sensors are difficult to locate spatially. Need to make sure they are reading contact data at a nominal load. Once a desired load is reached, data is collected for 5 secs (pressure data is collected manually as kinematic data is also recorded). This can be automated. The team will discuss this further. Information on trigger and pause (automation of processes) functionality will be requested from Tekscan.
   • Specimen preparation and registration.
     • Ahmet summarized the workflow based on the flowchart.
     • The motion analysis marker setup may bend (for example at the brass plug-bone attachment) during transportation. Distance between some points on the sensor and a set of points on the bone/ or some other location can be measured before and after transportation (for MRI) to ensure there was no deformation of the set up.
     • In the patella registration markers (using the 3D printed attachment), points cannot be picked on the surface of the embedded spheres. Therefore registration between imaging data and digitized marker data (points picked in notches made in the 3D printed triangular disc and related to the spheres from 3D drawings) may have errors (including the printing error) and needs to be quantified.
2. Discuss specimen transportation device design and options.
   • Craig and Snehal will contact machine shop to discuss potential design and material alternatives.
3. Discuss preparations for Martin Garon's visit next week.
   • Snehal will prepare the test samples for demo.
   • Robb will get the quotes for all potential configurations.
4. Decide tasks for the next meeting.
   • See Immediate Action Items and notes above for details.
5. Other.
   • None noted.