Recurring Meeting of Cleveland Clinic Core Team

Date: February 25, 2014

Time: 10:30 AM EST

Means: In person meeting

Attendees:

1. Ahmet Erdemir
2. Jason Halloran
3. Craig Bennetts
4. Snehal Chokhandre
5. Robb Colbrunn
6. Cara Sullivan

Agenda:

1. Discuss immediate action items from the last meeting.
2. Update on imaging.
3. Update on pressure measurement trial 2.
4. Update on manufacturing of testing accessories.
5. Discuss progress of all other tasks.
6. Decide immediate action items for the next meeting.
7. Other.

Immediate Action Items:

• Robb
  • Summarize the protocol on equilibration/calibration trials in pressure calibration specifications wiki page.
  • Finalize patella marker assembly design and manufacturing.
• Snehal
  • Continue responding requests in tissue sample preparation pages.

• Jason & Snehal

  • Search for knees for imaging trials.

• Snehal & Robb

  • Decide on the location of dedicated space for vibratome and tissue testing machine.
• Ahmet
  • Send the whole team Biomch-L entry and Crain's Business Cleveland article on Open Knee.
• Cara
  • Explore scenarios for a Kickstarter type video to promote Open Knee(s) project.

Notes:

1. Discuss immediate action items from the last meeting.
   • Response to pressure measurement related action items are summarized in its own agenda item (see below).
   • Activities related to manufacturing of testing accessories are summarized in its own agenda item (see below).
   • Imaging related issues will be discussed as its own agenda item (see below).
   • Snehal made changes to the infrastructure page, which included adding descriptions of the grips, punches, vibratome, etc. for tissue testing.
   • Snehal will be working on the tissue sample preparation pages.
   • Ahmet sent an email to Biomch-L to announce the project and to ask for community involvement related to specifications.
   • Cara summarized an approach for general purpose data management. She'll upload her summary after today's meeting. This info could be reiterated on the specifications page related to data management.
   • Related to robotics testing a few issues are being worked on. Robb highlighted the cross talk between the transducers during flexion, registration between the the Optotrak cameras and definition of the coordinate systems, account for the load offsets for a given tibia holder angle. Robb aims to have these worked out before he returns from the ORS, which occurs on March 24.
2. Update on imaging.
   • Jason should check field of views between iso 0.4 mm and iso 0.5 mm T1 protocols (old and new). An imaging trial was set up for next week. Ahmet summarized the plan for next week's test imaging session at UH. The group agreed it is a good approach. The target protocols for the next imaging trial should be documented in the specifications page of anatomical imaging. Jason and Snehal will look for other specimens just in case we could image another sample.
3. Update on pressure measurement trial 2.
   • Robb summarized calibration and equilibration of the pressure measurement. Equilibration was performed using the available foot testing bladder (up to around 90 psi) and calibration was conducted with relatively stiff plastic spheres. Multiple locations on the sensor were tested. Ahmet asked whether two different materials could be used, one for calibration and another for verification of results. This could be used to understand the effects material properties on the results.
4. Update on manufacturing of testing accessories.
   • The design for the patella registration phantom was discussed. An estimated quote was provided by MDS and it appears some of the probing home on the curved surfaces are incorrect. Robb will request the design changes (holes) and explore the repeatability and “toughness” of the alignment pins. This should be taken care of this week to test during next week's test imaging session.
5. Discuss progress of all other tasks.
   • Updates are progressing as planned.
6. Decide immediate action items for the next meeting.
   • See Immediate Action Items above for details.
7. Other.
   • Ahmet provided a summary of Stanford University - Cleveland Clinic monthly conference call. The mockup interface for cloud computing is essentially complete. The “hooks” are there, now the simulations need to be incorporated. The XSEDE startup allocation was discussed. Specifications related to the simulations are being created, which includes the required resources and simulation architecture. The framework is being developed for use in other computational resources (e.g. Amazon Elastic Computing, etc.). Data management was discussed. Midas or “Box” options were discussed and Ahmet, at first glance, prefers the Midas infrastructure. See meeting minutes for more detail.
   • The setup for the tissue testing was discussed. There is a concern that the existing space is over-utilized and used by multiple groups for various purposes. Two options were discussed; either behind the robot on the first floor or the existing counter in the basement. Snehal will explore the counter behind the robot and decide if the space is adequate for testing, which includes considering the vibrations from the large robot and the space to work with both the vibratome and the materials testing machine.
   • Robb informed that Cleveland Clinic Art and Photo Department is interested in development of videos (production and shooting) in a subsidized manner. The team may use it for increasing visibility. It maybe asking the video team to record experimentation session. Ahmet will send material to Cara, and the whole team, summarizing the recent Crain's Cleveland Business news and Biomch-L announcements. This should facilitate development of promotional material for Open Knees.
   • The team needs to document timing (step-by-step schedule) of specimen preparation, imaging, and testing. This will also allow bringing in the surgeon for tissue dissection. March 24, 2014 is the earliest anticipated day for experimentation readiness.