Recurring Meeting of Cleveland Clinic Core Team

Date: March 11, 2014

Time: 10:30 AM EST

Means: In person meeting

Attendees:

1. Ahmet Erdemir
2. Jason Halloran
3. Craig Bennetts
4. Snehal Chokhandre
5. Robb Colbrunn

Agenda:

1. Discuss immediate action items from the last meeting.
2. Update on anatomical imaging.
3. Evaluation of readiness for mechanical joint testing.
4. Update on data management approach.
5. Decide immediate action items for the next meeting.
6. Other.

Immediate Action Items:

• Jason and Robb
  • Receive patella marker assembly.
  • Receive relative coordinates of divots and center of spheres of the patella marker assembly as designed.
  • Measure divots of patella marker assembly using a digitizer.
  • Measure sphere centers of patella marker assembly using MRI.
• Robb
  • Summarize pressure sensor calibration/equilibration on specifications page of pressure measurement.
• Snehal
  • Provide initial labeling convention in editable form in the data management specifications wiki.
• Ahmet and Craig
  • Setup next trial imaging session.
• Snehal
  • Put information for next trial imaging session on the imaging specifications page.
• Jason, Ahmet and Snehal
  • Update specimen preparation to reflect discussions in the meeting.

Notes:

1. Discuss immediate action items from the last meeting.
   • The calibration/equilibration procedure has not been updated. Jason and Robb will summarize the current work, much like the imaging specifications.
   • Jason needs to verify the accuracy of the patella registration marker. The divots will be measured with the Optotrak (or Microsribe) and the inter-divot and repeatability of the probing will be evaluated.
   • Tara has not made any changes to the tissue preparation page.
   • Snehal and Ahmet reviewed the specimen preparation page. It "mostly" looks fine though some of the workflow needs to be discussed.
   • Snehal summarized the three acquired specimens using the oks001 through oks00# convention.
     • Current specimens will be considered "candidates" until the screening qualifies their use for that specimen (e.g. healthy versus osteoarthritic once the knees are opened).
     • The samples oks00# will not change if they don't qualify for that specific criteria. The reason for exclusion will be summarized on the page and the sample could be , though it wouldn't represent the desired characteristics.
     • Regarding summarizing the specimen/sampling labeling convention, Snehal and Craig summarized the minimum number of tissue samples to help qualify the labelling convention. The summary was uploaded as a text document and will be translated to the wiki for editing purposes.
   • Ahmet summarized his feedback where we might consider separating the tissue type and location identifier.
   • The "test type" may need to be associated with the data and not the sample. The discussion led to using the framework Snehal proposed, likely minus the testing condition. The "test type" will be associated with the data itself and will be populated in the wiki so the users know the specimen history.
2. Update on anatomical imaging.

   • The trial session from last week (March 4) was completed. A "new" (previously tested by the BioRobotics Core) knee was imaged and the summary is on the Specifications/AnatomicalImaging page. The next session and/or final approach to imaging needs to be decided on. Another candidate imaging session will potentially be setup.

   • After much discussion, it was decided that the next imaging session should focus on the MESE settings (slice thickness and different planes) to decide if the ligaments can be created from these scans. To summarize the next trial ( it may have with the patella marker attached ):
     • MESE 0.35 by 0.35 by 3.0 mm in sagittal
     • MESE 0.35 by 0.35 by 3.0 mm in coronal
     • MESE 0.35 by 0.35 by 3.0 mm in axial
     • MESE 0.35 by 0.35 by 1.0 mm with a 2.0 mm gap in sagitall
     • MESE, same resolution as previous but with number of excitations set to 3 (to increase the signal to noise ratio).
     • T1_3D with fat suppression with 0.35 by 0.35 by 0.7 mm for a higher resolution look at important structures. Sagittal plane
3. Evaluation of readiness for mechanical joint testing.
   • There is some discrepancy about the order of operations.
   • The specimen preparation page does not exactly align with the current specimen mechanical testing page.
   • The actual flow of work was discussed and relevant pages will be updated to reflect the changes.
   • Essentially, the initialization of the JCS needs to be accounted for, which currently includes probing points on the malleoulus and the epiphyseal of the femur.
   • A meeting will be set up (Jason, Ahmet, Snehal) to fix the current workflow and Tara will be asked to verify the information.
   • Robb summarized the progress on the robot set-up. The loads on the holder need to be verified after digitization. Related, the cross-talk in the mechanical system will be evaluated as a function of the flexion axis position and movement of the plate.
4. Update on data management approach.
   • See notes in discussed immediate action items.
5. Decide immediate action items for the next meeting.
   • Immediate action items were assigned and agreed upon.
6. Other.
   • Ahmet created a wiki page to describe efforts and plans made to promote the project.
   • He also added the information provided by Cara for development of an introductory promotional video.