Recurring Meeting of Cleveland Clinic Core Team

Date: July 7, 2015

Time: 10:30 AM EST

Means: In person meeting

Attendees:

1. Ahmet Erdemir
2. Snehal Chokhandre
3. Craig Bennetts
4. Tara Bonner
5. Omar Gad
6. Connor Lough
7. Diana Suciu
8. Raghav Malik

Agenda:

1. Discuss immediate action items from the last meeting.
2. Discuss research student assignments for the remaining term.
3. Decide immediate action items for the next meeting.
4. Other.

Immediate Action Items:

• Craig
  • Provide sample MR images for oks008 in the relevant wiki page.
  • Convert meniscal horn ligaments in Open Knee(s) - Generation 1 model to tension only.
• Snehal
  • Continue testing all tissue types at 20%/s to evaluate the capacity for a simplified testing scheme.
  • Schedule imaging for the remainder of the year.
• Robb
  • Conduct post-experiment calibration of pressure sensor used for oks008 testing.
• All Students
  • Update/review image segmentation and geometry generation specifications.
• Connor
  • Finish segmenting registration markers.
  • Update registration error estimation script relying on marker distances and angles.
  • Complete definition of springs between tibia and menisci in Open Knee(s) - Generation 1 model.
• Diana
  • Continue working with Tara to complete verification of contact pressure analysis with Robb and Tara (using Tekscan original files).
  • Complete definition of springs between MCL and medial meniscus in Open Knee(s) - Generation 1 model.
• Omar
  • Talk to Raghav on the implementation of springs in the Open Knee(s) - Generation 1 file.
  • Complete definition of springs to represent transverse ligaments between menisci in Open Knee(s) - Generation 1 model.
• Raghav
  • Work with Snehal on background and lighting of the specimen for minimizing uncertainties in thickness measurement.
  • Complete features for removal of artificial thickness measurements.
  • Meet Omar and start learning FEBio for future implementation of springs to represent additional structures.

Ongoing Action Items:

• Ahmet
  • Dissemination of joint mechanics testing data.
  • Prepare flowcharts to describe data flow for pre-processing of joint kinematics/kinetics data.
• Craig
  • Anatomical imaging manuscript.
  • Large-scale analysis of simulation parameters for convergence.
• Snehal
  • Continue interacting up with Biomomentum, Inc. about mechanical testing system tuning features.
  • Complete the additional structured testing plan for tuning the system for different sample sizes, strain levels and strain rates.
  • Pivot shift manuscript.

  • Cruciate ligament modeling & simulation.

  • Evaluate alternative tissue testing strategy.
• Robb
  • Patellofemoral joint experimentation manuscript.
• Tara
  • Tibiofemoral joint experimentation manuscript.

Notes:

1. Discuss immediate action items from the last meeting.
   • Ahmet described the updated image segmentation specifications. Mainly, tissue labeling. Details can be found at Specifications/ImageSegmentation. For now different numbers can be used at the end of the label for different versions of same tissue.
   • Craig will update sample MRIs for oks008.
   • Snehal will continue to test trial (non oks) tissue samples at 20%/s strain rate. The hold times for trials will be reduced to 2 mins from 30 mins.
   • A camera and required lens were ordered to build the optical thickness measurement system. Raghav will take the items once delivered.
   • Robb will conduct post-experiment calibration of pressure sensor used for oks008 testing.
   • Connor changed scripts to accommodate for patella registration marker. HE also compared distances between markers. Ahmet suggested determinining percent error and angles between the markers as well.
   • Diana met with Robb to verify contact pressure measurements from script with Tekscan software.
   • Omar met with Connor and Diana to describe implementation of springs in the Open Knee(s) - Generation 1 file.
   • Raghav updated the thickness measurement script to manually remove measurements that aren't correct. He will work with Snehal to test image acquisition environments.
   • Diana, Omar and Connor are also working on adding spring elements to Open Knee gen1 model. ( Omar: transverse ligament, Diana: medial meniscus to MCL, Connor: menisci to tibia).
2. Discuss research student assignments for the remaining term.
   • All students will continue working on adding springs to openknee gen 1 model.
   • they will also continue to segment oks image data sets.
   • Connor will segment registration markers for all specimens.
   • Diana will continue to segment all bones.
   • Omar will focus on segmenting cartilage and meniscus.
   • Raghav will work on segmenting ligaments.
   • All students will also segment all bones and cartilage for oks001 for user variation comparison.
   • All students were advised to document the method they are using for segmentation in a readme file in appropriate folder.
3. Decide immediate action items for the next meeting.
   • See Immediate Action Items above.
4. Other.
   • Final presentations for students were discussed.
   • All work should be presented in parts (3 parts for 3 projects (data processing script, segmentation, model)). With each part made up of introduction, methods, results, discussion
   • Ahmet also asked all mid-term presentations to be put in 'Summer2015/doc/' folder in the repository.