Recurring Meeting of the Advisory Board

Date(s): May 26-27, 2016

Due to scheduling conflicts, the group meeting with the Advisory Board members were scheduled on an individual basis with each member. Please refer to Meeting Minutes for more details.

Progress Report

Project Specific Aims

• To provide an open, freely available, and collaborative development, testing, simulation and dissemination platform for in silico exploration of the biomechanics of healthy and diseased knees.
• To develop in silico biomechanical models of healthy and diseased knee joints of different genders and ages, supported by specimen-specific joint and tissue level experimental mechanics.

Project Infrastructure

• https://simtk.org/projects/openknee (project website)

• https://simtk.org/plugins/moinmoin/openknee/ (project wiki)

Project Contact

• Ahmet Erdemir, PhD, erdemira@ccf.org, https://simtk.org/users/aerdemir

Advisory Board

• Clinical. Jack Andrish, MD; Carl Winalski, MD; Morgan Jones, MD, MPH; Paul Saluan, MD (Cleveland Clinic)

• Engineering. Yasin Dhaher, PhD (Northwestern University); Trent Guess, PhD (University of Missouri), Rami Korhonen, PhD (University of Eastern Finland)

Progress Period

• November 20, 2015 - May 25, 2016

Development Team during Progress Period

• Cleveland Clinic Core Team. Craig Bennetts, Tara Bonner, Snehal Chokhandre, Robb Colbrunn, Ahmet Erdemir

• Stanford University. Scott Delp, Joy Ku, Henry Kwong

• University of Utah. Ben Ellis, Jeff Weiss, Steve Maas

• Community. Jason Halloran, Will Zaylor

See https://simtk.org/project/memberlist.php?group_id=485 for full details on the project team.

Goals of Progress Period

• Launch and test usability of web based computation infrastructure (Stanford University)
• Explore the possibility to implement additional convenience related features in simulation software (University of Utah)
• Complete joint imaging and joint mechanics experimentation on oks009, oks010, oks011 (Cleveland Clinic)
• Start tissue mechanics testing of all specimens (Cleveland Clinic)

• Continue development and review of modeling & simulation specifications (Cleveland Clinic & Community)

• Continue developing models for all specimens (Cleveland Clinic)

• Plan 2016 summer internship program as part of community projects (Cleveland Clinic & Community)

• Follow up with case studies on modeling & simulation (Cleveland Clinic & Community)

• Follow up publications for Open Knee(s) - Generation 2 data sets (Cleveland Clinic)

Please also refer to previous meeting minutes of the Advisory Board at RecurringMeetings/2015-11-19. It should be noted that the timeline of activities has deviated from the original proposal, i.e., see the Roadmap and the proposed timeline of the proposal in GrantInformation/proposal.pdf.

Activities of Progress Period

• Cloud computing prototype
  • TBD
• Simulation software features
  • TBD
• Experimentation
  • TBD

• Modeling & simulation

  • TBD
• Dissemination

• As of May 25, 2016, Open Knee(s) provided 9 packages (5,206 total downloads, 1215 unique downloads), see Open Knee(s) download page:

  • oks001 version g2-s1-v0.2.0.20150825 (113 unique users as of May 25, 2016)
  • oks002 version g2-s2-v0.2.0.20150916 (27 unique users as of May 25, 2016)
  • oks003 version g2-s3-v0.2.0.20151013 (15 unique users as of May 25, 2016)
  • oks004 version g2-s4-v0.2.0.20151029 (14 unique users as of May 25, 2016)
  • oks006 version g2-s6-v0.2.0.20150915 (12 unique users as of May 25, 2016)
  • oks007 version g2-s7-v0.2.0.20151021 (15 unique users as of May 25, 2016)
  • oks008 version g2-s8-v0.2.0.20151021 (20 unique users as of May 25, 2016)
  • oks009 version g2-s9-v0.2.0.20151208 (19 unique users as of May 25, 2016)

  • Open Knee - Generation 1 versions g1-s1-v1.1.0.391 & g1-s1-v1.0.1.202 (651 unique users as of May 25, 2016):

  • As of May 25, 2016, Open Knee(s) provided 11 developer, 5 user documentation in release form, see Open Knee(s) documents page.

  • With a few exceptions (as requested by a collaborating team), all of the project website; wiki site, e.g. specifications, meeting minutes; and source code repository are publicly accessible.

  • As of May 25, 2016, Open Knee(s) website received 11,081 page hits in the past 180 days with 1,329 unique visitors, see Open Knee(s) project activity. It should be noted that theses statistics were likely reset at the time of Simtk.org update during April 2016.

  • As of May 25, 2016, Open Knee(s) enabled 17 studies by external research teams, see Open Knee(s) publications page.

  • At this moment joint imaging and mechanical testing data are disseminated for eight knees: oks001, oks002, oks003, oks004, oks006, oks007, oks008 & oks009 (see Open Knee(s) download page).

• Community projects
  • TBD
• Publications
  • TBD
• Other
  • TBD

Details of activities can be found in past meeting minutes of various teams at RecurringMeetings.

Plans for Next Progress Period (November 20, 2015 - May 2016)

• TBD

It should be noted that the timeline of activities has deviated from the original proposal, i.e., see the Roadmap and the proposed timeline of the proposal in GrantInformation/proposal.pdf.

Meeting Minutes

Date, Time, Means:

• May 26, 2016, 11:30 AM EST, face-to-face meeting (TBD: AE,PS)
• May 26, 2016, 2:30 PM EST, face-to-face meeting/conference call (TBD: AE,JA,MJ,YD,TG)
• May 27, 2016, 8:00 AM EST, conference call (TBD: AE,RK)

Attendees:

1. TBD

Agenda:

1. Progress update, see progress report at:

   • https://simtk.org/plugins/moinmoin/openknee/RecurringMeetings/2016-05-26

2. Recap of previous meeting minutes, see meeting minutes at:

   • https://simtk.org/plugins/moinmoin/openknee/RecurringMeetings/2015-11-19

3. Action items for following meeting.
4. Other.

Immediate Action Items:

See notes for details.

• All Advisory Board Members

  • TBD

• Ahmet Erdemir

  • TBD

Notes:

1. Due to scheduling conflicts, a series of meetings were conducted to inform the Advisory Board about Open Knee(s) activities and get feedback.
2. Progress update.
   • TBD
3. Recap of previous meeting minutes.
   • TBD
4. Action items for following meeting.
   • See Immediate Action Items above.
5. Other.
   • TBD