Recurring Meeting of Cleveland Clinic Core Team

Date: June 28, 2016

Time: 10:30 AM EST

Means: In person meeting

Attendees:

1. Ahmet Erdemir
2. Snehal Chokhandre
3. Tara Bonner
4. Connor Lough
5. Jason Halloran (Cleveland State University)
6. Will Zaylor (Cleveland State University)

Agenda:

1. Discuss immediate action items from the last meeting.
2. Discuss progress of tissue testing protocol evaluation.
3. Discuss progress of joint testing and imaging data manuscripts.
4. Discuss segmentation plan and progress.
5. Decide immediate action items for the next meeting.
6. Other.

Immediate Action Items:

• Ahmet
  • Review the drafts of data manuscripts (July 10, 2016 deadline).
• Snehal
  • Continue documentation of tissue testing reproducibility.
  • Evaluate 150 gr load cell to ensure noise does not saturate measurements.
• Robb
  • Continue working on scripts to generate of aggregated contact pressure plots for patellofemoral joint manuscript.
• Connor
  • Write specifications for comparison of geometries.
• All
  • Start segmentation based on commitments listed in the Roadmap.

Notes:

1. Discuss immediate action items from the last meeting.
   • Action items were related to the agenda items; refer to discussions below.
2. Discuss progress of tissue testing protocol evaluation.
   • Martin Garon of Biomomentum, Inc. solved the problem of the system freezing with 150g load cell. When the force transducer was bumped into, it may be overloaded and the actuator will be locked giving the appearance of a system freeze. The actuator can be unlocked without restarting the data collection software. Ahmet asked Snehal to evaluate testing with the 150 g load cell to ensure system noise when the actuator is moving doesn’t saturate the measurements.
   • Martin Garon also evaluated the force transducer response when the transducer was attached to the machine with ceramic washers and plastic screws. The noise when the stage was moving remained indicating that it is a mechanical issue.
   • Snehal has been updating all the tissue testing related documentation.
   • Snehal has dissected a new knee specimen for trial testing.
   • Snehal showed some results from repeatability tests. These were aimed at generating the same force-displacement data for the sample where the reference displacement on all repeated tests were the same. She started with a rubber sample in unconfined compression; tested twice without moving the sample or remeasuring thickness and a third time with just removing and putting the sample back in the same. The force-displacement response appeared to be repeatable. She did the same testing with cartilage. The force-displacement response appeared to be repeatable with the first test slightly deviating from the other two; noted by visual inspection. This may be due to the second and third tests having a similarly relaxed state of the sample when compared to the first. Overall, the group decided that uncertainties in stress-strain curves will likely be due to thickness measurement and zero force displacement estimation. Snehal will support this analysis by quantitative metrics.
3. Discuss progress of joint testing and imaging data manuscripts.
   • Ahmet had plans to review the manuscripts by July 10, 2016.
4. Discuss segmentation plan and progress.
   • Connor generated the raw surfaces for oks001 per Ahmet's request.
   • Connor segmented bones for oks001 and all bones except patella for oks002. He followed the same specifications as Craig did. He needs to compare his geometries with those generated by Craig. He will write the specifications for comparing the two geometries. He should come up with a naming convention on how to save that data.
5. Decide immediate action items for the next meeting.
   • See Immediate Action Items above.
6. Other.
   • None noted.