Recurring Meeting of Cleveland Clinic Core Team

Date: November 15, 2016

Time: 10:30 AM EST

Means: In person meeting

Attendees:

1. Ahmet Erdemir
2. Snehal Chokhandre
3. Robb Colbrunn
4. Tara Bonner
5. Benjamin Landis
6. Petri Tanska (University of Eastern Finland)

Agenda:

1. Discuss immediate action items from the last meeting.
2. Discuss progress of tissue testing protocol evaluation.
3. Discuss segmentation progress.
4. Decide immediate action items for the next meeting.
5. Other.

Ongoing Action Items:

• Ahmet
  • Complete reviewing the drafts of data manuscripts.
  • Schedule Advisory Board meeting.
• Snehal
  • Contact other investigators on meniscus testing.
  • Conduct more repetitions for meniscus unconfined testing.
  • Update tissue testing data analysis to make sure relaxation steps are not filtered.
  • Continue filling in the dashboard for tissue testing reproducibility.
• All
  • Continue segmentation based on commitments listed in the Roadmap.

Notes:

1. Discuss immediate action items from the last meeting.
   • Most action items were related to the ongoing agenda items; refer to discussions below.
2. Discuss progress of tissue testing protocol evaluation.
   • Snehal continued testing meniscus to resolve unconfined compression testing repeatability issues. She tried testing trying to minimize swelling as much as possible. Testing was performed over three days. Sample was frozen in between tests, thawed and tested directly. Testing issues remained. She also conducted a retest by recompressing the sample to the initial thickness of a previous test. The group needs to explore more issues. Ahmet recommended Snehal to contact other investigators who tested meniscus in unconfined compression to ask for advice.
   • Robb asked about the medium. Snehal referred to literature that utilized multiple mediums and showed no difference. Petri mentioned that proteoglycan loss as a potential issue. Ahmet recommended testing beyond three tests.
   • Mach-1 continues to have issues with the camera. Martin cannot access to the computer. Robb recommends setting a Webex meeting for troubleshooting.
3. Discuss segmentation progress.
   • Robb and Tara updated the roadmap. Robb completed patella for all specimens except oks004. He still has to do the patellar cartilage. Tara finished medial meniscus segmentation of all knees. Ahmet asked her to work on lateral meniscus.
4. Decide immediate action items for the next meeting.
   • See Ongoing Action Items above.
5. Other.
   • Ben described his work to automate mesh generation, mesh assembly, and model generation from stl surfaces. He provided two Python scripts that can run with Salome to do this. The scripts are available for others to evaluate.