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'''Recurring Meeting of Cleveland Clinic Core Team'''

'''Date:''' December 20, 2016

'''Time:''' 10:30 AM EST

'''Means:''' In person meeting

'''Attendees:'''

 1. Ahmet Erdemir
 1. Snehal Chokhandre
 1. Robb Colbrunn
 1. Tara Bonner

'''Agenda:'''

 1. Discuss immediate action items from the last meeting.  
 1. Discuss progress of tissue testing protocol evaluation.
 1. Discuss segmentation progress.
 1. Decide immediate action items for the next meeting.
 1. Other.

'''Ongoing Action Items:'''

 * Ahmet
  * Write progress report for the Advisory Board meeting.
  * Complete reviewing the drafts of data manuscripts. 
 * Snehal
  * Continue filling in the dashboard for tissue testing reproducibility.
 * All
  * Continue segmentation based on commitments listed in the Roadmap.

'''Notes:'''

 1. Discuss immediate action items from the last meeting.  
  * Most action items were related to the ongoing agenda items; refer to discussions below. 
 1. Discuss progress of tissue testing protocol evaluation.
  * Snehal prepared a larger rectangular sample of meniscus, only by manually cutting it with a scalpel; without punching a cylindrical sample. She minimized soaking of the larger sample before testing and marked the sides of the sample. She conducted the test using the standard protocols (unconfined, 5-15% pre-conditioning at 1000 cycles at 2 Hz than up to 15% strain stress-relaxation test) and immediately took the sample out and refrigerated for two hours. She put back the sample and re-did test without remueasuring thickness). Repeatability improved, e.g. max error less than 10%. The next day she prepared another large sample and tested the same way; except she remeasured and incorporated the new thickness in between tests. Force-displacement varied but repeatability of the stress-strain response was reasonable, e.g. less than 10%. Snehal suspects that using a larger rectangular and uniform sample and minimizing soaking was helpful. She suspects that rectangular sample is more uniform than the cylindrical sample as the punching may result in an hourglass shape for the meniscus sample. In the following day, she conducted the same tests except with cylindrical samples punched out from larger samples. The repeatability was not favorable. Tara found hole saws and Robb recommended biopsy punches to cut cylindrical samples in a shearing mode rather than a punching mode. Ahmet recommended using these to see whether cylindrical sample preparation would improve repeatability. Snehal also mentioned that samples tested in different days came from the same meniscis. The difference between stress-strain response was less than 20%. This may have been attributed to tissue inhomogeneity or repeatability issues other than soaking. Ahmet also recommended to conduct a meniscus test without the bath to see the potential soaking effect.
 1. Discuss segmentation progress.
  * Robb finished oks004 patella bone as well. He is repeating segmentation of oks001 patellar cartilage before the moves on to other patellar cartilage segmentation.
 1. Decide immediate action items for the next meeting.
  * See Ongoing Action Items above.
 1. Other.
  * Ahmet mentioned Ben's work about importing Open Knee(s) models to other simulation software.