We can all envision a particular model being judged credible when put to particular uses in one biomedical research, development, or clinical context, but not when put to different uses in another context. To stimulate discussion, I suggest that a prerequisite for discussion of a model’s credibility...

Figure in this paper [ http://onlinelibrary.wiley.com/doi/10.1002/wsbm.1222/full ] helps make clear the complicated variety of intended uses of different model types within Pharma R&D—all could be classified as research models. 1. Does the Committee need some way to shrink the modeling & model use c...

I have several comments that hope will be useful. I'll take them one at a time, but not in order of the slides, starting with Need: Clinical urgency. "There is a pressing need to utilize computational modeling & simulation to support clinical research and decision making in healthcare." There is a p...