Regional blood flow during radiation delivery

[David Craft]

I am starting a project where I try to correlate the details of radiation delivery with white blood cell kill in a patient. This requires not super highly detailed blood flow rates regionally throughout the body, but rather a fairly coarse description of flux. Since we currently do not do this at all in the field of radiation oncology, even flux on a cubic cm scale would be great. Is simvascular a good way to go for this? Ideal would be first a sort of "average human" model that we could then scale or adapt to individual CT scans (which we typically use for radiotherapy planning). It does not make sense to do full patient specific scans and computations at this point.

Thanks for any pointers/leads!

[Hongzhi Lan]

Hi David,

Sorry for the late reply. Thanks for your interest! SimVascular is a specialized software package for modeling and simulation of cardiovascular blood flow. It's image based. If you already have an "average" model, I think it's possible to scale or maybe adapt according to individual CT scans. You can definitely contact us and we can talk about it in details.

Thanks,
SimVascular Development Team.

[Alison Marsden]

Hi David,

There are a number of models available on the vascular model repository (www.vascularmodel.com) that might be useful for your project. You could use these to look at some typical simulation results. SV can give you flux at different regions. There are also possibilities to use reduced order models that don't require a full CFD simulation (for example LPN or 1-D simulations). We'd be happy to help with this, perhaps by discussion via skype.

Alison