How to create muscle defect?

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Roman Malyk
Posts: 1
Joined: Tue Sep 11, 2012 2:11 am

How to create muscle defect?

Post by Roman Malyk » Mon Oct 08, 2012 12:57 pm

Hi,
I'm reseacher of orthopaedic institute from Ukraine.
I am delighted with the Opensim program.
I have some question about changing model of lower limb.
1) How can I create muscle defect? I need simulate defects of muscles after resection soft tissue tumor.
2) Is there anyone who is addressing the issue biomechanics of bone and soft tissue sarcoma?
3) Can Opensim calculate level of joint stability (for example, hip joint after reattachment abductor muscles)
4) Could you recommend me some lower limb models to work with muscle defects?
Thank you in advance.
With best wishes, Dr. Malyk R.
Dr. Malyk Roman
Orthopaedic surgeon
Researcher of bone tumor department
Sytenko Institute of Spine and Joint Pathology

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Jennifer Hicks
Posts: 30
Joined: Wed Sep 07, 2005 4:40 pm

Re: How to create muscle defect?

Post by Jennifer Hicks » Wed Oct 24, 2012 4:00 pm

Roman -

Thanks for your interest in OpenSim. Please see my responses below:

1) How can I create muscle defect? I need simulate defects of muscles after resection soft tissue tumor.
You could change the max isometric force of a muscle to simulate a reduction in strength. This is one possibility - the particular technique will depend on the details of the defect that you are modeling.

2) Is there anyone who is addressing the issue biomechanics of bone and soft tissue sarcoma?
There are one or two research teams that I know of, and may be more. For example, a PubMed search for Martelli and Viceconti may bring up some relevant papers.

3) Can Opensim calculate level of joint stability (for example, hip joint after reattachment abductor muscles)
There is no built in joint stability tool, but you can calculate Joint Reaction Loads:
http://simtk-confluence.stanford.edu:80 ... s+Analysis

4) Could you recommend me some lower limb models to work with muscle defects?
One of the gait models we distribute would be a good starting point (gait2354 or gait2392). See the model library:
http://simtk-confluence.stanford.edu:80 ... tal+Models

Best wishes,
Jen

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Yusuke Okita
Posts: 44
Joined: Sun Nov 21, 2010 11:25 pm

Re: How to create muscle defect?

Post by Yusuke Okita » Fri Oct 26, 2012 4:37 am

Hi, Roman

I'm also trying to simulate the gait of patients after muscle resection for soft tissue sarcoma. Let me add my opinions to Jen's.

1) How to create muscle defect
You can do it simply by deleting muscles if they are completely resected. Disabling muscles (checking off 'Enable') didn't work well in CMC or Static Optimization in my environment. In the case of partial resection, I might decide to decrease the maximum isometric strength of the muscles. In my opinion, we might also have to consider the asymmetry of muscle strength due to the weakness of the operated limb. (especially patients after long-term followup) There must be some other things to be considered such as nerve invasion, radiation, flap use, etc.

3) Biomecahnics of bone and soft tissue sarcoma
You can learn it by seeing the works of Taddei 2011, Carty 2010, Benedetti 2000, etc. for patients with bone sarcoma. I don't know good papers for STS, but I would recommend Komura 2004 or van der Krogt 2012 which see the effects of muscle weakness in walking using musculoskeletal simulation.

It's so great to find you studying in this field.
I hope this would help the discussion here.

Best regards,
Yusuke Okita

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