Provide a tutorial and hands-on tutorial models for agent-based pharmacometric modeling.
The tutorials in this publication outline the development and simulation results of three agent-based (AB) models: a pharmacokinetic (PK), pathology, and pharmacokinetic/pharmacodynamic (PKPD) models. 1) The AB PK model uses a two-compartment system, including five agents that transfer, store, and record simulation information. 2) The AB pathology model includes a Morbidity agent and Symptom information. 3) The AB PK/PD model integrates the two earlier models and allows the user to delivery an intervention Dose that diminishes Symptom until Dose is cleared.
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The three models are developed with Java, using the MASON multi-agent simulation toolkit. The AB PK model can be used to reproduce Figure 3 results. The AB pathology model can be used to reproduce Figure 4A results. The AB PK/PD model can be used to reproduce Figure 4B-E results. We encourage readers to expand upon and repurpose the models for additional use cases.
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