Gait modification has recently been proposed as a noninvasive, early intervention method to treat knee osteoarthritis (OA). Toe-in gait modification has been shown to reduce the first peak of the net external KAM, ), a key factor in knee OA disease progression, in patients with symptomatic medial compartment knee OA, but the effect of toe-in gait on muscle forces and knee loads is unknown. Investigating knee joint contact loads, specifically the internal forces and moments the joint structure carries, under toe-in gait conditions may better characterize this gait modification in terms of creating targeted intervention strategies. This project will allow for principles that govern relationships between muscles contributions and purposeful movement like gait modification to be uncovered. This work lays a foundation for future studies to further improve knee OA treatment.