An agent-based model of myocardial scar healing, implemented in MATLAB and Repast Simphony. The model tracks cell and collagen content and alignment over 6 weeks of simulated infarct healing.
Our group developed an agent-based model of myocardial scar healing, implemented in MATLAB and Repast Simphony. The model tracks migration, proliferation, and collagen remodeling by fibroblasts over 6 weeks of simulated infarct healing, incorporating the influence of regional strains, chemokine gradients, and local matrix orientation on the orientation of the fibroblasts and the collagen fibers they produce. The original model was published in the Journal of Physiology in 2012, and has been used with various minor modifications in several other papers and abstracts from our group since that time. If you use or adapt the model, please cite the original Journal of Physiology article: ROUILLARD AD, HOLMES JW. MECHANICAL REGULATION OF FIBROBLAST MIGRATION AND COLLAGEN REMODELING IN HEALING MYOCARDIAL INFARCTS, J PHYSIOL, 590(18):4585-4602, SEP 2012.