nFuzzyStates 6

starttime 0.0
endtime 28400.0
ntimesteps 72000

PopulationSize 1
nGenerations 1
mutationRate 0.05

Exp 


Plot Shh
Plot Gli1
Plot Ptc1
Plot Smo
Plot Tumor

Node time 0.0 0.0 0.2 0.4 0.6000000000000001 0.8 1.0 
Node Shh 0.1 0.0010 0.020800000000000003 0.040600000000000004 0.06040000000000001 0.08020000000000001 0.1 
Node NmycP 0.0 0.0 0.2 0.4 0.6000000000000001 0.8 1.0 
Node Ptc1 0.5 0.0 0.2 0.4 0.6000000000000001 0.8 1.0 
Node Smo 0.0 0.0 0.2 0.4 0.6000000000000001 0.8 1.0 
Node Gli1 0.0 0.0 0.2 0.4 0.6000000000000001 0.8 1.0 
Node Gli2 0.0 0.0 0.2 0.4 0.6000000000000001 0.8 1.0 
Node pSwitch 1.0 0.0 0.2 0.4 0.6000000000000001 0.8 1.0 
Node Tumor 0.0 0.0 0.2 0.4 0.6000000000000001 0.8 1.0 
Node TransEvent 1.0 0.0 0.2 0.4 0.6000000000000001 0.8 1.0 
Reaction ShhOn 0.0010 
  pro Shh 5 5 5 5 5 0 0 0 0 0 0 0 
  time time 5 5 5 5 5 5 0 0 0 0 0 0 

Reaction PTC1_baseline 5.0E-5 
  pro Ptc1 5 5 5 5 5 0 0 0 0 0 0 0 

Reaction PTC1 5.0E-4 
  pro Ptc1 5 5 5 5 5 0 0 0 0 0 0 0 
  act Gli1 0 1 2 3 4 5 0 0 0 0 0 0 
  act pSwitch 0 1 2 3 4 5 0 0 0 0 0 0 

Reaction PTC1_nofb 0.0020 
  pro Ptc1 5 5 5 5 5 0 0 0 0 0 0 0 
  inh Shh 5 4 3 2 1 0 0 0 0 0 0 0 

Reaction Ptc1Decay 0.0010 
  sub Ptc1 0 1 2 3 4 5 0 0 0 0 0 0 

Reaction SmoActivation 0.0020 
  pro Smo 5 5 5 5 5 0 0 0 0 0 0 0 
  inh Ptc1 5 2 1 1 0 0 0 0 0 0 0 0 

Reaction SmoInactivation 0.0020 
  sub Smo 0 1 2 3 4 5 0 0 0 0 0 0 

Reaction GLI2 0.0020 
  pro Gli2 5 5 5 5 5 0 0 0 0 0 0 0 
  act Smo 0 0 1 1 2 5 0 0 0 0 0 0 

Reaction Gli2Decay 0.0010 
  sub Gli2 0 1 2 3 4 5 0 0 0 0 0 0 

Reaction GLI1 0.0020 
  pro Gli1 5 5 5 5 5 0 0 0 0 0 0 0 
  act Gli2 0 1 2 3 4 5 0 0 0 0 0 0 

Reaction Gli1Decay 0.0010 
  sub Gli1 0 1 2 3 4 5 0 0 0 0 0 0 

Reaction NmycPSynthesis 2.0E-4 
  pro NmycP 5 5 5 5 5 0 0 0 0 0 0 0 
  act Shh 0 0 2 3 4 5 0 0 0 0 0 0 

Reaction NmycP_decay 2.0E-4 
  sub NmycP 0 1 2 3 4 5 0 0 0 0 0 0 
  inh Shh 5 4 3 2 0 0 0 0 0 0 0 0 

Reaction TumorGrowth1 0.0020 
  act Gli1 0 0 0 1 3 3 0 0 0 0 0 0 
  act NmycP 0 1 2 3 4 5 0 0 0 0 0 0 
  act TransEvent 0 1 2 3 4 5 0 0 0 0 0 0 
  pro Tumor 5 5 5 5 5 0 0 0 0 0 0 0 

Reaction TumorApoptosis 0.0020 
  sub Tumor 0 1 2 3 4 5 0 0 0 0 0 0 

GENOME 423
  25
  15
  6
  6
  25
  3
  3
  3
  3
  3
  3
  3
  3
  3
  3
  3
  3
  3
  3
  3
  1
  0
  0
  5
  5
  5
  5
  5
  5
  0
  0
  0
  0
  0
  0
  4
  0
  1
  5
  5
  5
  5
  5
  0
  0
  0
  0
  0
  0
  0
  3
  0
  5
  4
  3
  2
  1
  0
  0
  0
  0
  0
  0
  0
  11
  0
  0
  0
  2
  3
  4
  5
  0
  0
  0
  0
  0
  0
  12
  0
  5
  4
  3
  2
  0
  0
  0
  0
  0
  0
  0
  0
  3
  11
  1
  5
  5
  5
  5
  5
  0
  0
  0
  0
  0
  0
  0
  12
  -1
  0
  1
  2
  3
  4
  5
  0
  0
  0
  0
  0
  0
  13
  0
  0
  1
  2
  3
  4
  5
  0
  0
  0
  0
  0
  0
  5
  1
  1
  5
  5
  5
  5
  5
  0
  0
  0
  0
  0
  0
  0
  2
  1
  5
  5
  5
  5
  5
  0
  0
  0
  0
  0
  0
  0
  3
  1
  5
  5
  5
  5
  5
  0
  0
  0
  0
  0
  0
  0
  4
  -1
  0
  1
  2
  3
  4
  5
  0
  0
  0
  0
  0
  0
  5
  0
  5
  2
  1
  1
  0
  0
  0
  0
  0
  0
  0
  0
  3
  5
  1
  5
  5
  5
  5
  5
  0
  0
  0
  0
  0
  0
  0
  6
  -1
  0
  1
  2
  3
  4
  5
  0
  0
  0
  0
  0
  0
  7
  0
  0
  0
  1
  1
  2
  5
  0
  0
  0
  0
  0
  0
  4
  2
  0
  0
  1
  2
  3
  4
  5
  0
  0
  0
  0
  0
  0
  9
  1
  5
  5
  5
  5
  5
  0
  0
  0
  0
  0
  0
  0
  10
  -1
  0
  1
  2
  3
  4
  5
  0
  0
  0
  0
  0
  0
  13
  0
  0
  0
  0
  1
  3
  3
  0
  0
  0
  0
  0
  0
  3
  7
  1
  5
  5
  5
  5
  5
  0
  0
  0
  0
  0
  0
  0
  8
  -1
  0
  1
  2
  3
  4
  5
  0
  0
  0
  0
  0
  0
  9
  0
  0
  1
  2
  3
  4
  5
  0
  0
  0
  0
  0
  0
  1
  2
  0
  0
  1
  2
  3
  4
  5
  0
  0
  0
  0
  0
  0
  2
  13
  1
  5
  5
  5
  5
  5
  0
  0
  0
  0
  0
  0
  0
  14
  -1
  0
  1
  2
  3
  4
  5
  0
  0
  0
  0
  0
  0
  1
  13
  0
  0
  1
  2
  3
  4
  5
  0
  0
  0
  0
  0
  0
  0
  0
  0
  0
  0
  0
  0
  0
  0
  0
  0
  0
  0
  0
  0