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scorer

scorer is used to comparea predicted secondary structure to an accepted structure. It calculates two quality metrics, sensitivity and PPV (positive predictive value).

USAGE: scorer <predicted ct> <accepted ct> <output file> [options]

Required parameters:

<predicted ct> The name of a file containing predicted structure data in ct format.
<accepted ct> The name of a file containing accepted structure data in ct format.
<output file> The name of a text file to which output will be written.

Options which don't require added values:

-e, -E, --exact Specify exact comparison between structures when scoring.
Default is to allow a predicted pair to differ by up to one nucleotide on one side of a pair as compared to the accepted structure. See CircleCompare: exact option" for details.
-h, -H, --help Display the usage details message.
-p, -P, --print Print the output file to standard output.
This won't override the default behavior of writing to a file.

Options which require added values:

NONE

References

  1. Reuter, J.S. and Mathews, D.H.
    "RNAstructure: software for RNA secondary structure prediction and analysis."
    BMC Bioinformatics, 11:129. (2010).
  2. Mathews, D.H., Sabina, J., Zuker, M. and Turner, D.H.
    "Expanded sequence dependence of thermodynamic parameters provides improved prediction of RNA secondary structure."
    J. Mol. Biol., 288:911-940. (1999).
  3. Mathews, D.H.
    "Using an RNA secondary structure partition function to determine confidence in base pairs predicted by free energy minimization."
    RNA, 10:1178-1190. (2004).