position: 5' end of the target site overall: overall free energe change of the equilibrium duplex: free energy change of the sense-antisense hybrid duplex breaking: the free energy cost to open the binding site's base pairs Tm: melting temperature of sensen-antisense duplex intraoligo: free energy change of intra-oligomer structure interoligo: free energy change of inter-oligomer (antisense dimer) structure end_diff: the difference of the free enegy change of the two ends of siRNA duplex (5' end - 3' endwindow size: 2) sequence: the sequence of antisense siRNA (5'-3') --------------------------------------------------------------------------------- position overall duplex breaking Tm intraoligo interoligo end_diff pre_filter_score sequence 1 -20.8 -30.2 -9.4 76.7 0 -8.9 0.16 6 CCAAUUCCACCAAAAUAGC 2 -19.1 -28.5 -9.4 74.8 0 -8.8 0.74 6 ACCAAUUCCACCAAAAUAG 11 -25.0 -31.4 -5.7 78.7 -0.1 -10 0.56 6 AUCGUGUCUACCAAUUCCA 17 -25.0 -31.7 -5.2 79.7 -1.3 -11.5 0.73 6 AAGAGUAUCGUGUCUACCA 18 -25.0 -31.4 -4.9 78.8 -1.3 -11.6 1.93 7 UAAGAGUAUCGUGUCUACC 19 -22.8 -29 -4.8 75.3 -1.2 -11.5 1.76 6 UUAAGAGUAUCGUGUCUAC 22 -21.6 -29 -5.3 74.3 -0.2 -13.8 1.7 7 AUCUUAAGAGUAUCGUGUC 24 -20.7 -28.7 -5.6 74.2 -0.3 -14.4 0.77 6 ACAUCUUAAGAGUAUCGUG 25 -19.0 -27.4 -5.5 73.1 -0.6 -15.4 0.46 6 UACAUCUUAAGAGUAUCGU 26 -18.1 -26.8 -5.3 71.1 -1.2 -16.4 1.26 7 AUACAUCUUAAGAGUAUCG 27 -16.5 -25.3 -5 68.7 -1.6 -17.1 1.87 8 AAUACAUCUUAAGAGUAUC 30 -17.4 -25.6 -5.9 70.6 -0.2 -14.2 0.16 8 AGUAAUACAUCUUAAGAGU 31 -16.7 -24.8 -6 68.7 -0.4 -13.8 1.6 6 AAGUAAUACAUCUUAAGAG 32 -16.2 -23.1 -5.2 66.4 -0.5 -12.9 0.97 7 AAAGUAAUACAUCUUAAGA 33 -17.6 -22.5 -4 65.3 -0.5 -10.7 1.2 6 UAAAGUAAUACAUCUUAAG 42 -13.5 -23.3 -7.3 67.2 -2.5 -11.5 0.4 7 UUCAUACUGUAAAGUAAUA 46 -20.7 -27.2 -5.4 73.9 -0.7 -11.3 0.86 7 AACCUUCAUACUGUAAAGU 55 -20.4 -29.6 -7.2 76.7 -1.8 -12.8 0.4 7 AAGGACUUGAACCUUCAUA 56 -19.9 -29.2 -6.9 75.9 -2.3 -13.3 0.17 6 AAAGGACUUGAACCUUCAU 57 -19.9 -29.4 -7.2 76.9 -2.2 -13.3 0.33 7 UAAAGGACUUGAACCUUCA 58 -18.8 -28.7 -7.6 75.2 -2.2 -13.3 1.87 7 UUAAAGGACUUGAACCUUC 60 -17.3 -26.9 -8.1 73.1 -1 -12.1 0.53 8 AUUUAAAGGACUUGAACCU 61 -17.3 -26.6 -8.2 72.1 -0.4 -11.5 1.93 8 UAUUUAAAGGACUUGAACC 62 -17.8 -25.9 -7 70.2 -0.4 -11.5 0.16 7 CUAUUUAAAGGACUUGAAC