Title

Patellofemoral Joint Mechanics – Part 3 of Comprehensive Data for Specimen-Specific Knee Modeling

Authors

Robb W. Colbrunn1,2, Jason P. Halloran1,3, Tara F. Bonner1,2, Snehal Chokhandre1,4, Craig J. Bennetts1,4, Ahmet Erdemir1,4

Affiliations

Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA

BioRobotics and Mechanical Testing Core, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA

Department of Mechanical Engineering, Cleveland State University, Cleveland, Ohio, USA

Computational Biomodeling (CoBi) Core, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA

Abstract

With comprehensive testing, specimen-specific knee models can be developed to represent not only individualized anatomy but also tissue mechanical properties. When data on joint mechanics are available, credibility of these models, in terms of their potential to reproduce joint response, can be established. Open Knee(s) was launched for these purposes, where specimen-specific mechanics of the patellofemoral joint were measured on eight cadaver specimens - a small but diverse sample population. This document aims to describe and disseminate patellofemoral joint mechanics data, and to provide related experimentation details. Using a robotics system, kinematics-kinetics and contact pressures of the joint were characterized under quadriceps loads (up to 600 N) at 0°, 15°, 30°, 45°, and 60° of flexion. The data will assist in specimen-specific evaluation of patellofemoral joint simulations when using models based on joint anatomy and tissue mechanical properties acquired from the same specimens. Stand-alone, the data provide the foundations for phenomenological modeling, i.e., describing patellar tracking and contact as a function of tibiofemoral joint kinematics and quadriceps load.

Background & Summary

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Acknowledgements

This study was part of Open Knee(s) initiative, which was funded by the National Institute of General Medical Sciences, National Institutes of Health (NIH) under Grant R01GM104139 (Principal Investigator: Ahmet Erdemir). Insights provided by the Open Knee(s) Advisory Board on testing procedures are greatly appreciated. Open Knee(s) Advisory Board was formed by physicians Jack Andrish, Morgan Jones, Paul Saluan and Carl Winalski, and researchers Yasin Dhaher, Trent Guess and Rami Korhonen. The authors would like to acknowledge Jack Andrish, Morgan Jones, and David Brigati for specimen evaluation, preparation, and follow-up dissection. Dylan Beckler, Omar Gad, Callan Gillespie, Nicholas Haas, Connor Lough, Eryn Merico, Nicole Nassif, Katie Stemmer, Diana Suciu, William van den Bogert, and Will Zaylor assisted specimen preparation and experimentation in an intermittent fashion. Open Knee(s) was enabled through SimTK.org, project hosting platform of Simbios, NIH Center for Biomedical Computation at Stanford University. Support from Scott Delp, Joy Ku, and Henry Kwong from Simbios team is acknowledged. Up-to-date information on Open Knee(s) project can be found at https://simtk.org/projects/openknee.

Author contributions

Robb W. Colbrunn led the execution of patellofemoral joint testing workflow including specimen preparation, and acquisition and interpretation of data; assisted in organization of data sets and dissemination; outlined and provided the first draft of the manuscript and approved the final version to be published.

Jason P. Halloran contributed to the conceptualization of the work; assisted in execution of patellofemoral joint testing workflow including equipment preparation, and acquisition and interpretation of data; reviewed and contributed to the drafts of the manuscript, and approved the final version to be published.

Tara F. Bonner assisted in execution of patellofemoral joint testing workflow including specimen preparation and acquisition of data; assisted in organization of data sets and dissemination; reviewed and contributed to the drafts of the manuscript, and approved the final version to be published.

Snehal Chokhandre assisted in execution of patellofemoral joint testing workflow including specimen preparation; reviewed and contributed to the drafts of the manuscript, and approved the final version to be published.

Craig J. Bennetts assisted in execution of patellofemoral joint testing workflow including specimen preparation; reviewed and contributed to the drafts of the manuscript, and approved the final version to be published.

Ahmet Erdemir led the conceptualization of the work; assisted in execution of patellofemoral joint testing workflow including specimen preparation, acquisition and interpretation of data; led the organization of data sets and dissemination; outlined, reviewed and contributed to the drafts of the manuscript, and approved the final version to be published.

Competing interests

Robb W. Colbrunn and Tara F. Bonner receive royalties from each copy of simVITRO® software sold under a licensing agreement from the Cleveland Clinic Innovations. Ahmet Erdemir owns and operates innodof, LLC, a consulting company for modeling and simulation. The remainder of author(s) declare no competing financial interests.

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2016-05-06T14:08:00