Title

Tibiofemoral Joint Mechanics – Part 2 of Comprehensive Data for Specimen-Specific Knee Modeling

Authors

Tara F. Bonner1,2, Robb W. Colbrunn1,2, Snehal Chokhandre1,3, Craig J. Bennetts1,3, Ahmet Erdemir1,3

Affiliations

Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA

BioRobotics and Mechanical Testing Core, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA

Computational Biomodeling (CoBi) Core, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA

Abstract

In the development of virtual knees for clinical and scientific simulations, evaluating their predictive capacity to reproduce tibiofemoral joint kinematics-kinetics is a necessary step. Open Knee(s) was launched to build computational knee models with complete specimen-specificity, including geometry and mechanical properties. Within the Open Knee(s) framework, tibiofemoral joint mechanics were measured for eight cadaver specimens. The goals of this document are to provide the specifics of tibiofemoral joint testing, and to describe and disseminate the resultant data. Kinematics-kinetics were characterized at 0°, 30°, 60°, and 90° of flexion using a robotics system. Laxity tests, internal rotation (±5 Nm), varus (±10 Nm), and anterior translation (±100 N), were performed along with combined loading. The data will support assessment of simulation performance in a specimen-specific manner when models utilize joint anatomy and tissue mechanical properties acquired from the same specimens. For a small but diverse sample of population, the data set, by itself, provides information for phenomenological modeling of tibiofemoral joint mechanics and outlines the design space for its restoration.

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Acknowledgements

This study was part of Open Knee(s) initiative, which was funded by the National Institute of General Medical Sciences, National Institutes of Health (NIH) under Grant R01GM104139 (Principal Investigator: Ahmet Erdemir). Insights provided by the Open Knee(s) Advisory Board on testing procedures are greatly appreciated. Open Knee(s) Advisory Board was formed by physicians Jack Andrish, Morgan Jones, Paul Saluan and Carl Winalski, and researchers Yasin Dhaher, Trent Guess and Rami Korhonen. The authors would like to acknowledge Jason Halloran for providing his expertise to design and execute testing protocols; and Jack Andrish, Morgan Jones, and David Brigati for specimen evaluation, preparation, and follow-up dissection. Dylan Beckler, Omar Gad, Callan Gillespie, Connor Lough, Eryn Merico, Katie Stemmer, Diana Suciu, and Will Zaylor assisted specimen preparation and experimentation in an intermittent fashion. Open Knee(s) was enabled through SimTK.org, project hosting platform of Simbios, NIH Center for Biomedical Computation at Stanford University. Support from Scott Delp, Joy Ku, and Henry Kwong from Simbios team is acknowledged. Up-to-date information on Open Knee(s) project can be found at https://simtk.org/projects/openknee.

Author contributions

Tara F. Bonner led the execution of tibiofemoral joint testing workflow including specimen preparation, and acquisition and interpretation of data; assisted in organization of data sets and dissemination; outlined and provided the first draft of the manuscript and approved the final version to be published.

Robb W. Colbrunn contributed to the conceptualization of the work; assisted in execution of tibiofemoral joint testing workflow including acquisition of data; assisted in organization of data sets and dissemination; reviewed and contributed to the drafts of the manuscript, and approved the final version to be published.

Snehal Chokhandre assisted in execution of tibiofemoral joint testing workflow including specimen preparation; reviewed and contributed to the drafts of the manuscript, and approved the final version to be published.

Craig J. Bennetts assisted in execution of tibiofemoral joint testing workflow including specimen preparation; reviewed and contributed to the drafts of the manuscript, and approved the final version to be published.

Ahmet Erdemir led the conceptualization of the work; assisted in execution of tibiofemoral joint testing workflow including interpretation of data; led the organization of data sets and dissemination; outlined, reviewed and contributed to the drafts of the manuscript, and approved the final version to be published.

Competing interests

Robb W. Colbrunn and Tara F. Bonner receive royalties from each copy of simVITRO® software sold under a licensing agreement from the Cleveland Clinic Innovations. Ahmet Erdemir owns and operates innodof, LLC, a consulting company for modeling and simulation. The remainder of author(s) declare no competing financial interests.

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2016-05-06T14:08:00