Collaborators Meeting

Date: November 16, 2021

Time: 5:00 PM US/Eastern

Means: MS Teams

Attendees:

  1. Jason Halloran (WSU)
  2. Carl Imhauser (HSS)
  3. Kevin Shelburne (DU)
  4. Peter Laz (DU)
  5. Thor Andreassen (DU)
  6. Thor Besier (ABI)
  7. Marco Schneider (ABI)
  8. Nynke Rooks (ABI)
  9. Ahmet Erdemir (CC)
  10. Snehal Chokhandre (CC)

Agenda:

  1. Renewal grant submission.
  2. Manuscripts in preparation.
  3. Model Benchmarking updates.
  4. Model Reuse preparation.
  5. Other.

Immediate Action Items:

Notes:

  1. The renewal grant was submitted. Ahmet noted that the proposed activities may be ambitious, i.e., we may have underestimated the effort needed to establish consensus using the Delphi method. Nonetheless, the two specific aims, to establish consensus workflows and to evaluate their reproducibility, fit well together.
  2. Manuscript on knee model reviews for reproducibility is ready for submission. The initial submission to Journal of Biomechanics was not well received. The manuscript was modified in view of reviewer comments. It can be submitted to Journal of Orthopaedics Research or to a special issue of Frontiers on reproducibility. The former will provide the opportunity to reach out to the relevant orthopaedics and musculoskeletal research community. Yet, the metascience nature of the article may not be well received in a journal with more traditional research focus. The latter journal and issue directly resonates with the theme. Jason can make the decision. Submission should be before the end of year.
  3. Carl noted that the credibility workshop manuscript can be submitted as well. Ahmet noted that a complete draft should be circulated soon (in a week or two) if that is the goal. Submission should be before the end of year.
  4. There was a long discussion on the manuscript for Model Calibration phase. Pete and Kevin requested that the teams fill in the tables that they circulated. They reiterated their desire to provide simulation results and reminded about their request from the groups to submit their results for select simulation cases. Kevin noted that the article can start with kinematics results of passive flexion (all teams, after recalibration). If the results are different, the art of calibration becomes important. If not, the art does not matter but the burden of different workflows may need to be elaborated on, e.g. extent of calibration data that were used, computational cost, labor, etc. Therefore, processes of each team should be compared and contrasted. This outline for the manuscript will also prepare the foundations for the reporting of Model Benchmarking. We also learned a lot by going through both calibration and recalibration. Some of these lessons may be incorporated in the manuscript on Model Calibration phase. Yet, it is likely that they may result in another article to retain focus, i.e. on data reporting and interpretation. Thor Andreassen asked about including tissue level forces, stresses. Ahmet noted that if these are already accessible in simulation results we can report. In some cases, simulation may need to be rerun and post-processing needs to be performed (ligament forces). That may result in delay and may not necessarily add on deciphering the art of calibration. This should definitely be explored for Model Reuse phase as some of these metrics will have scientific and/or clinical importance.
  5. Ahmet asked about Model Recalibration and Benchmarking calibrations. Jason is evaluating the package from Will. Carl will follow up with Shady (who recently got a new position) to see the status. ABI and DU submitted their packages. Ahmet asked all to resend the links again to him and Snehal.
  6. Ahmet wants to start the Model Reuse phase. He plans to keep simulation scenarios as simple as possible: passive flexion as we did before (maybe with modeler's coordinate systems - rather then registered experimental); pivot shift with and without ACL (function of flexion, internal-external rotation and varus-valgus torques; maybe including reporting of ACL force); standing -x-ray (constant flexion with half body weight compression); and sit-to-stand. For the latter, we will not necessarily apply individual muscle loads. Rather, we will likely apply a joint force/moment trajectory after flexing the knee to 90 degrees. Ahmet intends to write up a wiki page for this phase, ideally before the end of the year. One month can be spared for preparation of specifications (Jan 2022) and three-months to execute to phase (Feb-Apr 2022).
  7. Overall, the goal is to wrap up the manuscripts and the phases before any resubmission of the renewal grant (possibly in July 2022).

2021-11-16 (last edited 2021-11-18 13:46:41 by aerdemir)