Recurring Meeting of Cleveland Clinic Core Team

Date: March 29, 2016

Time: 2:00 PM EST

Means: In person meeting

Attendees:

1. Ahmet Erdemir
2. Tammy Owings
3. Benjamin Landis
4. Tara Bonner

Agenda:

1. Discuss immediate action items from past meetings.

   • http://wiki.simtk.org/multis/RecurringMeetings/2016-03-22

2. Readiness for in vivo testing.
3. Decide immediate action items for next meeting.
4. Other.

Immediate Action Items:

• Ahmet & Tammy

  • Conduct a mock up session to evaluate in vivo testing protocols.
• Ben
  • Re-evaluate in vivo testing protocols described in the relevant specifications page.
  • Move on to quadratic tetrahedral meshes for the curved section problem.
• Tammy
  • Provide additional pictures for in vivo testing protocols in the relevant specifications page.
  • Order surgical mat.

• Robb & Tara

  • Document data file labeling for in vivo testing.
  • Convert subject configuration format to XML.
  • Continue working on software implementation for collection and utilization of orientation data.
• Tara
  • Incorporate recording of system configuration, e.g., transformations, within the force data files of in vivo testing.

Notes:

1. Discuss immediate action items from past meetings.
   • Ahmet informed the team that the fixture to connect ultrasound probe and force transducer and the accompanying handle were manufactured.
   • Ben had trouble getting the linear tetrahedral elements converge for the model of a thin curved section under indentation. Hexahedral meshes ran fast. Ben will try the use of quadratic tetrahedral elements to evaluate their performance.
   • The Modeler was compiled and is ready for use. Ben will start learning it to develop models for SOFA.
   • Tammy has been working on the finer details of the in vivo protocol, i.e. organization in sections. She summarized her updates to the specifications wiki page. Her updates are inline with Ben's recommendations based on his first review. Ben will go over the document again. Tammy will include more pictures and additional details on how to transfer the data.
   • Ahmet mentioned that the magnetic resonance imaging session (for in vitro testing) was rescheduled for April 12, 2016. Tammy has been in touch with Snehal Chokhandre. The bag for transportation of specimen has been ready.
   • Tammy identified the surgical mat to purchase, she will get a quote.
   • Ahmet and Tammy will have a mock up session to evaluate the workflow during in vivo testing. This is scheduled for upcoming Thursday at 1 PM. Tammy will verify with Russ Fedewa the availability of the ultrasound system. Tara will likely join the session. The ultrasound probe - force transducer assembly will be evaluated along with the interface for force measurements.
   • Ahmet asked Tara about saving subject information as an XML file. Tara's impression was that the XML file should contain information from all subjects. Ahmet corrected this miscommunication by emphasizing the each subject will have an XML file and we would not necessarily need a file that contains information from all subjects. Tara will work on implementation details.
   • Ahmet asked about the possibility to save information in configuration files in the actual TDMS files where the data are stored. Tara will see if that is possible.
2. Readiness for in vivo testing.
   • Pending work on data collection system are listed below:
     • Tara will incorporate updates to data collection scheme; specifically saving of subject file as XML, and recording of transformations within the force measurement data file.
     • Robb will continue integrating the orientation sensor to Tara's data collection software.
     • A working version of the data collection software is available for mock up testing. Tammy suggested to have a note option to document why a trial is rejected. This may help understand whether data from a trial should be discarded or can be reused.
   • Ahmet received the manufactured parts of the ultrasound probe - force transducer fixture and handle in an assembled form. After mock up session, additional design changes need to be implemented.
   • Documentation of operating procedures for in vivo testing has been matured. Additional updates are expected to be minor.
   • Also, refer to relevant discussions listed in the agenda item above.
   • The group discussed the analysis workflow for the in vivo data. When the desired subject is known, one can identify the desired anatomical region for analysis and find the force data file. The name of the force data file is encoded in the ultrasound data, which can accommodate associating the ultrasound images with the force data. Temporal alignment of the force data and ultrasound images will provide the possibility to extract the time history of tissue thickness as a function of indentation force. Tammy suggested that we plan and evaluate an analysis strategy before starting testing of human subjects.
3. Decide immediate action items for next meeting.
   • See Immediate Action Items above.
4. Other.
   • None noted.