This is the development site of Operation MULTiS - Reference Models for Multi-Layer Tissue Structures. The development efforts for this project have been organized by Ahmet Erdemir and supported by CoBi Core, BioRobotics Testing Core, the Multidisciplinary Simulation Center of the Cleveland Clinic, and Simbios of the Stanford University.

This research and development project titled “Reference Models for Multi-Layer Tissue Structures" was conducted by the Cleveland Clinic Foundation and was made possible by a contract vehicle which was awarded and administered by the U.S. Army Medical Research & Materiel Command under award number: W81XWH-15-1-0232. The views, opinions and/or findings contained in this website are those of the authors and do not necessarily reflect the views of the Department of Defense and should not be construed as an official DoD/Army position, policy or decision unless so designated by other documentation. No official endorsement should be made.

Grant Information

proposal.pdf

Visibility & Outreach

Journal Articles

Published articles

See list of articles being planned/drafted.

Conferences

See Conferences where portions of this project have been presented.

Roadmap

The overall goal of this study is to establish the founding knowledge, data and models for the mechanics of multi-layer tissue structures of the limbs, particularly of the lower and upper legs and arms. By delivering this lacking information, the activity will promote scientific research in layered tissue structures and allow reliable virtual surgery simulations for clinical training and certification. Below is a list of project milestones, which correspond to the specific objectives of the project.

Project Duration. September 1, 2015 - August 31, 2018

Each milestone (or a task within a milestone) is staged to assist a Go / No Go type of decision process:

Milestones

YEAR 1

Web-based interfaces for data curation, queryable data and model databases.

YEAR 1

In vivo multi-layer tissue anatomy and indentation mechanics.

YEARS 1-2

In vitro multi-layer tissue anatomy, mechanical properties, and indentation mechanics.

YEAR 2

In vitro quantification of tool forces during surgery of multi-layer tissue structures.

YEAR 2

Physiologically realistic, fully specimen-specific, nonlinear reference models.

YEAR 2

Physiologically realistic, partially subject-specific, nonlinear reference models.

YEAR 3

Computationally efficient surrogate models for multi-layer tissue structures.

YEAR 3

Demonstration of efficient surrogate models of multi-layer tissue structures.

YEARS 1-3

Population and dissemination of data and models.

Roadmap for web based interfaces

Roadmap for in vivo testing

Roadmap for in vitro testing (ultrasound indentation)

Roadmap for in vitro testing (surgical tools)

Roadmap for reference models (in vitro)

Roadmap for reference models (in vivo)

Roadmap for surrogate models

Roadmap for demonstration

Specifications

Infrastructure

Recurring Meetings

FrontPage (last edited 2019-10-09 12:11:34 by ricimorrill1)