This is the development site of Operation MULTiS - Reference Models for Multi-Layer Tissue Structures. The development efforts for this project have been organized by Ahmet Erdemir and supported by CoBi Core, BioRobotics Testing Core, the Multidisciplinary Simulation Center of the Cleveland Clinic, and Simbios of the Stanford University.
This research and development project titled “Reference Models for Multi-Layer Tissue Structures" was conducted by the Cleveland Clinic Foundation and was made possible by a contract vehicle which was awarded and administered by the U.S. Army Medical Research & Materiel Command under award number: W81XWH-15-1-0232. The views, opinions and/or findings contained in this website are those of the authors and do not necessarily reflect the views of the Department of Defense and should not be construed as an official DoD/Army position, policy or decision unless so designated by other documentation. No official endorsement should be made.
Contents
- Grant Information
- Visibility & Outreach
-
Roadmap
- Milestones
- Roadmap for web based interfaces
- Roadmap for in vivo testing
- Roadmap for in vitro testing (ultrasound indentation)
- Roadmap for in vitro testing (surgical tools)
- Roadmap for reference models (in vitro)
- Roadmap for reference models (in vivo)
- Roadmap for surrogate models
- Roadmap for demonstration
- Specifications
- Infrastructure
- Recurring Meetings
Grant Information
Visibility & Outreach
Journal Articles
Published articles
Schimmoeller T, Cho KH, Colbrunn R, Nagle T, Neumann E, Erdemir A. Instrumentation of Surgical Tools To Measure Load and Position During Incision, Tissue Retraction, and Suturing. Conf Proc IEEE Eng Med Biol Soc. 2018 Jul;2018:933-936. doi: 10.1109/EMBC.2018.8512332. PMID: 30440543
Neumann EE, Owings TM, Schimmoeller T, Nagle TF, Colbrunn RW, Landis B, Jelovsek JE, Wong M, Ku JP, Erdemir A. Reference data on thickness and mechanics of tissue layers and anthropometry of musculoskeletal extremities. Sci Data. 2018 Sep 25;5:180193. doi: 10.1038/sdata.2018.193. PMID: 30251995
Schimmoeller T, Colbrunn R, Nagle T, Lobosky M, Neumann EE, Owings TM, Landis B, Jelovsek JE, Erdemir A. Instrumentation of Off-The-Shelf Ultrasound System for Measurement of Probe Forces During Freehand Imaging. J Biomech. 2019, 83:117-124. doi: 10.1016/j.jbiomech.2018.11.032. PMID: 30514629
Neumann EE, Owings TM, Erdemir A: Regional variations of in vivo surface stiffness of soft tissue layers of musculoskeletal extremities. J Biomech. (Epub ahead of print).
Schimmoeller T, Neumann E, Owings T, Nagle T, Colbrunn R, Landis B, Jelovsek JE, Hing T, Ku J, Erdemir A: Reference data on in vitro anatomy and mechanics of tissue layers of musculoskeletal extremities. Sci Data. (in review).
Schimmoeller T, Neumann E, Nagle T, Erdemir A: Reference tool kinematics-kinetics and tissue surface strain data during fundamental surgical acts. Sci Data. (in review).
See list of articles being planned/drafted.
Conferences
See Conferences where portions of this project have been presented.
Roadmap
The overall goal of this study is to establish the founding knowledge, data and models for the mechanics of multi-layer tissue structures of the limbs, particularly of the lower and upper legs and arms. By delivering this lacking information, the activity will promote scientific research in layered tissue structures and allow reliable virtual surgery simulations for clinical training and certification. Below is a list of project milestones, which correspond to the specific objectives of the project.
Project Duration. September 1, 2015 - August 31, 2018
Each milestone (or a task within a milestone) is staged to assist a Go / No Go type of decision process:
Readiness of infrastructure. Are all necessary resources to accomplish the task available?
Readiness of specifications (standard operating procedures). Are the specifications of the task detailed enough to follow through?
Mock up runs. Is there a need to update specifications to respond to unforeseen issues?
Execution of specifications. Do the resultant outcomes of specifications match desired deliverables of the task?
Dissemination of deliverables. Are deliverables shared within the project team and with the community to feed into follow up tasks?
Milestones
YEAR 1 |
Web-based interfaces for data curation, queryable data and model databases. |
YEAR 1 |
In vivo multi-layer tissue anatomy and indentation mechanics. |
YEARS 1-2 |
In vitro multi-layer tissue anatomy, mechanical properties, and indentation mechanics. |
YEAR 2 |
In vitro quantification of tool forces during surgery of multi-layer tissue structures. |
YEAR 2 |
Physiologically realistic, fully specimen-specific, nonlinear reference models. |
YEAR 2 |
Physiologically realistic, partially subject-specific, nonlinear reference models. |
YEAR 3 |
Computationally efficient surrogate models for multi-layer tissue structures. |
YEAR 3 |
Demonstration of efficient surrogate models of multi-layer tissue structures. |
YEARS 1-3 |
Population and dissemination of data and models. |
Roadmap for web based interfaces
Readiness of infrastructure.
- Initial prototypes
Readiness of specifications. see Specifications/DataManagement
- Completion of specifications and identification of infrastructure
Mock up runs.
- Completion of prototype evaluation
Execution of specifications.
Dissemination of deliverables.
- Beta, gamma, and delta were released for in vivo, in vitro, and surgical tools data, respectively.
Roadmap for in vivo testing
Readiness of infrastructure. see Infrastructure/InstrumentedUltrasound
Readiness of specifications. see Specifications/InVivoTesting
Mock up runs. see Specifications/InVivoTesting/Discussion
Execution of specifications. see Subjects
Dissemination of deliverables. see Licensing for terms of use and distribution of data
Dynamic Data Managment Site: https://multisbeta.stanford.edu/
Static DOI: https://www.doi.org/10.18735/S5R97F
Roadmap for in vitro testing (ultrasound indentation)
Readiness of infrastructure. see Infrastructure/InstrumentedUltrasound, Infrastructure/TestingRoom & Infrastructure/Imaging
Readiness of specifications. see Specifications/InVitroTesting
- Completion of specifications for indentation
- Completion of specifications for anatomical imaging
- Completion of specifications for tissue testing
- Completion of specifications for development of testing platform
Mock up runs.
Execution of specifications. see InVitroExperiments
- Start of experiments
Dissemination of deliverables.
Dynamic Data Managment Site: https://multisgamma.stanford.edu/
Roadmap for in vitro testing (surgical tools)
Readiness of infrastructure. see Infrastructure/InstrumentedSurgicalTools, Infrastructure/TestingRoom & Infrastructure/Imaging
- Initial prototype for surgical tool - force transducer integration
Readiness of specifications. see Specifications/InVitroTesting
- Completion of specifications for surgical manipulation
- Completion of specifications for spatial strain measurement and digital video recording
Mock up runs.
Execution of specifications. see InstToolsExperiments
- Start of experiments
Dissemination of deliverables.
Dynamic Data Managment Site: https://multisdelta.stanford.edu/
Roadmap for reference models (in vitro)
Readiness of infrastructure.
Readiness of specifications. see IndentationModeling
Mock up runs.
Execution of specifications.
Dissemination of deliverables.
Roadmap for reference models (in vivo)
Readiness of infrastructure.
Readiness of specifications. see IndentationModeling
Mock up runs.
Execution of specifications.
Dissemination of deliverables.
Roadmap for surrogate models
Readiness of infrastructure.
Readiness of specifications. see IndentationModeling and SofaBasics
Mock up runs.
Execution of specifications.
Dissemination of deliverables.
Roadmap for demonstration
Readiness of infrastructure.
Readiness of specifications.
Mock up runs.
Execution of specifications.
Dissemination of deliverables.
Specifications
Infrastructure
Recurring Meetings
see minutes for Recurring Meetings