• RecurringMeetings
• 2013-10-22

Recurring Meeting of Cleveland Clinic Core Team

Date: October 22, 2013

Time: 10:30 AM EST

Means: In person meeting

Attendees:

1. Ahmet Erdemir
2. Jason Halloran
3. Snehal Chokhandre
4. Tara Bonner

Agenda:

1. Discuss assigned tasks progress.
2. Discuss expected tissue testing expenses and potential purchasing of tissue testing equipment.
3. Decide action items for next meeting.
4. Other

Immediate Action Items:

• See notes for details.

  • Snehal

    • Update specimen specification details and order specimens after the specifications have been reviewed and agreed upon.

    Ahmet

    • Send copy of the quote from Biomomentum for the tissues testing machine that we may potentially buy.
    • Contact NIH for equipment purchase policies.

    Tara

    • Provide Snehal a description of acceptable parameters for previously ordered specimens.

    Jason

    • Finish a workable version of imaging settings before meeting with Chris on Oct 28th.

  • All

    • Read and update/modify all specifications before next meeting.

Notes:

1. Discuss assigned task progress.
   • Ahmet reviewed the minutes for last week's meeting.
   • Ahmet scheduled meetings with the advisory board.
   • Ahmet, Jason, Snehal will meet Dr. Winalski on Monday, October 28th at 7.00 am.
   • Jason created a flowchart for experimental operations.
   • Specimen specifications
     • Specimen selection criteria was decided.
     • Snehal will update the specifications and order the specimens this week, if possible.
     • Check exclusion criteria from previous orders.
     • Order, billing and delivery details will be updated.
     • Sub-sample details will be update as the other specifications development progresses.
   • Imaging specifications
     • Craig updated the page with previously used specifications.
     • Craig found relevant references to improve the specifications to better suit out needs.
     • Different sets of acquisition settings will be tested.
     • Different imaging sequences might be used to get images that might be easier to segment semi-automatically.
     • Ahmet and Jason will meet Chris on 28th.
     • A workable version of the imaging setting will be decided before the meeting.
     • Registration markers placement etc information should be included in specimen preparation.
     • Imaging settings must also focus on registration marker image quality along with the soft tissue.
     • Information about specimen transportation (using the fixture made for previous studies) will be added.
   • Robotics testing specifications
     • Specify target outcome.
     • The team will read and edit these specifications and complete them by the next meeting on Oct 29th.
   • Registration specifications and specimen preparation tasks were created.
   • FEBio feature specifications
     • Jason prepared a list of feature requests and created a priority list.
     • Jason also created a test problem.
     • Details will be discussed with the Utah group on Oct. 23th.
     • The FEBio current feature request was deemed complete.
   • Publications
     • Scott will start working on the Open Knee Generation 1 manuscript.
     • Ahmet will submit a one page manuscript to Journal of Medical Devices as part of ASME/FDA meeting.
   • Documentation
     • FEBio summary was updated by Ben and Ahmet.
     • Will be discussed with the Utah group to complete the task.
     • Mechanical experimentation infrastructure task will be updated by Tara and Robb with relevant information about available equipment (including links).
2. Discuss expected tissue testing expenses and potential purchasing of tissue testing equipment.
   • Alternatives were discussed to keep the tissue experimentation cost to the minimum without limiting the data that can be acquired for the study.
     • The minimum number of samples that need to be tested is 18 for each specimen. With a 3 hr of testing time and $100/ hr of machine time, the minimum cost of one set of tests will be $5400, excluding the indirect costs.
     • Some alterations will also be made to the existing protocols to reduce test time.
     • Three alternatives were discussed to try to circumvent this issue and provide more flexibility to the experimenters (with room for errors).
     • A fixed fee for the duration of the study with unlimited use of the testing equipment (indirect costs will apply).
     • Cost sharing for buying and maintaining new equipment with the robotics core.
     • Purchasing testing equipment for the grant (Ahmet had requested a quote from Biomomentum Inc.). This may be the cheapest option as no indirect costs will apply and experimenters will not be limited by cost of testing.
     • Ahmet, Snehal, Tara and Robb will meet next week to discuss the issue further and finalise a solution.
3. Decide action items for next meeting
   • All task specifications development will continue.
   • Check immediate action items for details.
4. Other
   • Ahmet updated infrastructure/scripting environment information.
   • Auxiliary software useful for model development were also listed by Ahmet.
   • Structure of source code repository is also being developed by Ahmet.