Recurring Meeting of the Advisory Board

Date(s): October 28 - November 1, 2013

Due to scheduling conflicts, the group meeting with the Advisory Board members were scheduled on an individual basis with each member. Please refer to Meeting Minutes for more details.

TableOfContents

Progress Report

Project Specific Aims

• To provide an open, freely available, and collaborative development, testing, simulation and dissemination platform for in silico exploration of the biomechanics of healthy and diseased knees.
• To develop in silico biomechanical models of healthy and diseased knee joints of different genders and ages, supported by specimen-specific joint and tissue level experimental mechanics.

Project Infrastructure

• https://simtk.org/home/openknee (project website)

• http://wiki.simtk.org/openknee (project wiki)

Project Contact

• Ahmet Erdemir, PhD, erdemira@ccf.org, https://simtk.org/users/aerdemir

Advisory Board

• Clinical. Jack Andrish, MD; Carl Winalski, MD; Morgan Jones, MD, MPH; Paul Saluan, MD (Cleveland Clinic)

• Engineering. Yasin Dhaher, PhD (Northwestern University); Trent Guess, PhD (University of Missouri), Rami Korhonen, PhD (University of Eastern Finland)

Progress Period

• September 16, 2013 - October 28, 2013

Development Team during Progress Period

• Cleveland Clinic Core Team. Craig Bennetts, Tara Bonner, Snehal Chokhandre, Robb Colbrunn, Ahmet Erdemir, Jason Halloran

• Stanford University. Scott Delp, Joy Ku, Henry Kwong

• University of Utah. Ben Ellis, Jeff Weiss, Steve Maas

• Community. Scott Sibole

See https://simtk.org/project/xml/team.xml?group_id=485 for full details on the project team.

Goals of Progress Period

• Organize workload of Cleveland Clinic, Stanford University, and University of Utah teams
• Start recurring meetings with team members
• Establish web based collaboration infrastructure
• Start development of web based computation infrastructure
• Start development of simulation software improvements
• Start development and review of experimentation specifications

For more details, see the proposed timeline of the proposal in attachment:GrantInformation/proposal.pdf.

Activities of Progress Period

• Organization

  • As part of a specifications task entitled Roadmap, a wiki page was created; see [http://wiki.simtk.org/openknee/Roadmap?action=recall&rev=14 Revision as of October 27, 2013] or [:Roadmap: current version]. The document provides centralized access to descriptions of infrastructure, specifications, and development milestones for Open Knee(s) utilities and models.

  • First set of meetings with [:RecurringMeetings/2013-09-30: Cleveland Clinic Core Team], between [:RecurringMeetings/2013-10-07-1700:Cleveland Clinic & Stanford University], and between [:RecurringMeetings/2013-10-07-1300:Cleveland Clinic & University of Utah] were conducted to distribute project workload, clarify expectations, and pinpoint deliverables.

• Recurring meetings

  • A task to establish recurring meetings has been completed by creating a wiki page; see [http://wiki.simtk.org/openknee/RecurringMeetings?action=recall&rev=26 Revision as of October 27, 2013] or [:RecurringMeetings: current version]. The document describes the means to conduct the meetings and also provides access to meeting minutes.

• Web based collaboration infrastructure

  • The project site at https://simtk.org/home/openknee provides the web based collaboration infrastructure for development and dissemination. Please refer to InstructionsForProjectSite to learn specific components of the web site.

  • The wiki at http://wiki.simtk.org/openknee provides the capacity for collaborative development of scientific content, e.g. specifications. Please refer to InstructionsForWiki to get accustomed to using the wiki.

  • The source code repository located at https://simtk.org/svn/openknee provides a version control system and the means for collaborative development of software, data analysis code, and models. Please refer to InstructionsForSourceCodeRepository to learn using this system.

  • Public has read access to all components of the web based collaboration infrastructure. The activity is an open development activity, also see ["Licensing"].

  • The project site, wiki, and source code repository was updated to move the previous Open Knee work as [:GenerationOne:Open Knee - Generation 1].

• Web based computation infrastructure
  • Cleveland Clinic and Stanford University had a conference call to discuss web based computation infrastructure. Please refer to [:RecurringMeetings/2013-10-07-1700: meeting minutes].

  • A specifications task entitled Test workflow for cloud computing prototype was created to provide a simple test problem on the wiki, in order to support development of a cloud computing prototype.

• Simulation software improvements
  • Cleveland Clinic and University of Utah had two conference calls to discuss improvement in simulation software. Please refer to meeting minutes ([:RecurringMeetings/2013-10-07-1300:October 7, 2013] and [:RecurringMeetings/2013-10-23:October 23, 2013]).

  • As part of specifications task entitled Febio feature requests, Cleveland Clinic team provided prioritization of desired FEBio features and a test problem in the wiki; see [http://wiki.simtk.org/openknee/Specifications/FebioFeatures?action=recall&rev=16 Revision as of October 27, 2013] or [:Specifications/FebioFeatures: current version].

  • Details of FEBio, simulation software for finite element analysis, can be found in ["Infrastructure/SimulationSoftware"].
• Experimentation specifications

  • Various specifications tasks were started and corresponding wiki pages have been created to document operation procedures to conduct experimentation on specimens. These pages are aimed to guide anyone to follow up the steps to reach the targeted outcome of a given experimentation procedure, in a nutshell to collect specimen-specific anatomical and mechanical data. The specifications wiki page lists all these along with an illustration of the overall experimentation workflow, see [http://wiki.simtk.org/openknee/Specifications?action=recall&rev=27 Revision as of October 27, 2013] or [:Specifications: current version].

  • A high priority specification is related to specimens in order to start acquisition of knee samples. A related wiki page is complete; see [http://wiki.simtk.org/openknee/Specifications/Specimens?action=recall&rev=19 Revision as of October 27, 2013] or [:Specifications/Specimens: current version]. An anticipated difficulty in this procedure is the potentially limited access to osteoarthritic knee specimens.

  • Before conducting anatomical imaging and mechanical testing, specimens need to be prepared appropriately. Relevant information has been accumulated in wiki pages related to preparation ([http://wiki.simtk.org/openknee/Specifications/SpecimenPreparation?action=recall&rev=9 Revision as of October 27, 2013] or [:Specifications/SpecimenPreparation: current version]) and registration ([http://wiki.simtk.org/openknee/Specifications/Registration?action=recall&rev=13 Revision as of October 27, 2013] or [:Specifications/Registration: current version]). Anticipated difficulties in these procedures are i) potential redesign of brass components to minimize imaging artifacts, ii) development of new holding fixtures to transport specimens, and iii) redesign of registration markers for femur and tibia.

  • Anatomical imaging, e.g. MRI, will lead into geometric representation of the knee joint. The Cleveland Clinic team has established collaborations with imaging facilities at the University Hospitals. A wiki page is in progress to identify a suitable imaging protocol based on our previous experiences, see [http://wiki.simtk.org/openknee/Specifications/ExperimentationAnatomicalImaging?action=recall&rev=11 Revision as of October 27, 2013] or [:Specifications/ExperimentationAnatomicalImaging: current version]. The Cleveland Clinic team and the imaging facility will explore different protocols to facilitate segmentation of tissues within the knee.

  • Primary and secondary mechanical testing conditions to characterize tibiofemoral and patellofemoral joint responses were decided upon. The Cleveland Clinic team, supported by the BioRobotics Core previously devised approaches for such testing. Detailed specifications are under development in a wiki page, see [http://wiki.simtk.org/openknee/Specifications/ExperimentationJointMechanics?action=recall&rev=32 Revision as of October 27, 2013] or [:Specifications/ExperimentationJointMechanics: current version].

  • Tissue testing will provide constitutive relationships for ligaments, tendons, meniscus, and cartilage for development of computational models. The Cleveland Clinic team, supported by the BioRobotics Core previously devised approaches for such testing. Detailed specifications on the extent of tissue samples and testing protocols are under development in a wiki page, see [http://wiki.simtk.org/openknee/Specifications/ExperimentationTissueMechanics?action=recall&rev=4 Revision as of October 27, 2013] or [:Specifications/ExperimentationTissueMechanics: current version]. Tissue testing can be costly due to large number of samples and long testing durations for appropriate characterization. Alternative strategies, such as acquisition of testing equipment dedicated to the project, are under consideration.

• Other

  • Open Knee was presented at the ASME/FDA 2013 1st Annual Frontiers in Medical Devices: Applications of Computer Modeling and Simulation, September 11-13, 2013, Washington, DC, see [https://simtk.org/websvn/wsvn/openknee/_gen1/doc/fmd_2013.pdf abstract]. An abridged version of this abstract was submitted to Journal of Medical Devices as one page article for publication.

  • For publication of previous work on Open Knee, various publication tasks were created. An outline and a draft of Open Knee - Generation 1 manuscript can be found in [https://simtk.org/websvn/wsvn/openknee/_gen1/doc/manuscript.odt source code repository].

For a complete list of various tasks (finished or in progress), please refer to https://simtk.org/pm/?group_id=485.

Plans for Next Progress Period (October 29, 2013 - May 2014)

• Complete a prototype of web based computation infrastructure (Stanford University)
• Complete implementation of high priority features in simulation software (University of Utah)
• Complete experimentation (specifications and data collection) for Specimen 001 (Cleveland Clinic)
• Disseminate data from Specimen 001 (Cleveland Clinic)

• Start development and review of modeling specifications (Cleveland Clinic & Community)

• Start development and review of simulation specifications (Cleveland Clinic & Community)

• Launch community projects program (reviews, internships, and collaborations) (Cleveland Clinic & Community)

• Publish previous work on Open Knee - Generation 1 (Cleveland Clinic)

For more details, see the proposed timeline of the proposal in attachment:GrantInformation/proposal.pdf.

Meeting Minutes

Date, Time, Means:

• October 28, 2013, 7:00 AM EST, in person meeting (AE,PS)
• October 29, 2013, 8:00 AM EST, in person meeting (AE,JH,CW)
• Ocbober 30, 2013, 2:00 PM EST, conference call (AE,YD,TG,RK)
• November 1, 2013, 9:00 AM EST, in person meeting (AE,JA,MJ)

Attendees:

1. Ahmet Erdemir (Cleveland Clinic)
2. Jason Halloran (Cleveland Clinic)
3. Jack Andrish (Cleveland Clinic)
4. Morgan Jones (Cleveland Clinic)
5. Paul Saluan (Cleveland Clinic)
6. Carl Winalski (Cleveland Clinic)
7. Yasin Dhaher (Northwestern University)
8. Trent Guess (University of Missouri)
9. Rami Korhonen (University of Eastern Finland)

Agenda:

1. Project description
2. Expectations from Advisory Board
3. Progress update
4. Scheduling of biannual meetings
5. Action items for following meeting
6. Other

Immediate Action Items:

See notes for details.

• TBD

Notes:

1. Due to scheduling conflicts, a series of meetings were conducted to inform the Advisory Board about Open Knee(s) activities and get feedback.
2. Project description
   • Ahmet iterated the specific aims of the project. He summarized the organization between (and roles of) Cleveland Clinic, Stanford University, and University of Utah teams and the Advisory Board and the community. Public nature of the project and the open development approach were emphasized.
3. Expectations from Advisory Board
   • The expected role of Advisory Board members were summarized.
     • Biannual review of progress report
     • Biannual meeting with Ahmet Erdemir to evaluate progress and provide input for upcoming activities
     • Intermittent, possibly individual, interactions with team members to consult on relevant specific activities to accomplish components of Open Knee(s)
4. Progress update
   • The progress report was summarized and relevant individual items were discussed in detail.
5. Scheduling of biannual meetings
   • The Advisory Board agreed on the scheduling of biannual meetings to evaluate progress; in late October - early November, and in late April - early May.
6. Action items for following meeting
   • Each Advisory Board member were asked to get an account in simtk.org. Ahmet will add them as team members to give them write access to the project site.
   • The Advisory Board members will familiarize themselves with the project site. They will provide feedback on the ease navigation of the site.
   • The Advisory Board members were also encouraged to comment on current progress and planned activities in case they did not raise such issues during these meetings.
7. Other
   • Ahmet informed the members from the Cleveland Clinic that a desk space was made available in the Biomechanics Laboratory of the Department of Biomedical Engineering.