Recurring Meeting of Cleveland Clinic Core Team

Date: November 26, 2013

Time: 10:30 AM EST

Means: In person meeting


  1. Ahmet Erdemir
  2. Jason Halloran
  3. Craig Bennetts
  4. Snehal Chokhandre
  5. Robb Colbrunn
  6. Tara Bonner


  1. Discuss tasks progress.
  2. Discuss specimen transportation device design and options.
  3. Compare quotes from other vendors and finalize tissue testing equipment purchase.
  4. Decide tasks for the next meeting.
  5. Other.

Immediate Action Items:

See notes for details.


  1. Discuss task progress.
    • Immediate action items were discussed.
      • FEBio feature specification development is on going. Cleveland Clinic team summarized the needs and has been providing test problems. Development of feature to prescribe in situ strains is in progress and the supplied test problem will be used. The need for the connector feature need was summarized and a test problem will be provided.
      • Craig updated the cloud computing prototype design. Cleveland Clinic and Stanford University teams met and discussed the gateway design, expectations, and implementation. Stanford University will work on the implementation in the following months.
      • Snehal obtained quotes from four vendors for the tissue testing machine and provided a cost and feature comparison. Robb has been communicating with the engineers of Biomomentum Inc. to reach an agreement for machine features and within budget constraints.
    • Imaging specifications.
      • Snehal updated sample images from the test session carried out at the University Hospitals on November 14, 2013. Snehal will add more sample images to the wiki page for different sequence types.
      • The T2 proton density sequence programmed by Chris Flask, in order to get better contrast for ligaments, did not seem to provide sufficient information for modeling.
      • Another imaging sequence was programmed to match the 3D DESS sequence from the study by Peterfy et al. (OAI study). Cartilage and meniscus can be seen clearly in these images and the team decided to use the current sequence setting for production. Snehal will add sample images from this dataset showing ligaments. The Field of view for 3D DESS images was smaller than other sequences.
      • The team decided to use the original T1 set for production.
      • T1 (good for ligaments) and 3D DESS (good for cartilage and meniscus) sequences will be used as primary conditions. In addition, an axial dataset will be needed for geometric reconstruction of ligaments. Any other supporting sequences will be added as secondary conditions. Imaging page will be updated accordingly.
      • Reporting for imaging sequences will be conducted based on the template in the OAI stud, i.e. reporting all the necessary sequence information, e.g., field of view, resolution.
      • The brass marker components and a piece of delrin were also imaged to check for image artifacts. The influence of large pieces of brass raised concerns. An estimate of artifact region needs to be made (also depends on protocol) based on the size of marker components. Smaller brass pieces, e.g., brass screws may be used with other marker components made out of delrin or any other plastic. Artifacts from the marker components should be limited to accommodate delineation of geometry particularly at the patellar region. Once developed for patella, similar marker sets will be made for femur and tibia.
    • Joint testing specifications.
      • Robb and Jason will address the queries requested by Ahmet.
    • Specifications for test workflow for cloud computing.
      • Craig provided detailed documentation for the Stanford team to implement the gateway interface.
      • Craig designed a sample interface layout which will be visible to the users. This interface will be designed such that the user can select a model (there will be an associated script to modify the model and a default configuration file), modify the configuration file if desired, and submit the model. An administration panel will be created so that other members (designated admins) can add models to the system. Another user interface for retrieval results will also be created.
  2. Discuss specimen transportation device design and options.
    • Craig will get some foam and PVC samples to start exploring prototype designs.
  3. Compare quotes from other vendors and finalize tissue testing equipment purchase.
    • Snehal summarized the testing needs (tissue type, sample size, load and displacement ranges, data acquisition frequencies, etc).
    • A cost and feature comparison was done for all the potential machines (from Instron Corp., MTS Systems Corp., Bose ElectroForce Corp., and Biomomentum Inc.). Machines from Instron Corp. and Bose ElectroForce Corp. did not meet the feature requirements and budget constraints; therefore they will not be considered.

    • The testing machine by Biomomentum Inc. (Mach-1 V500c) matches the basic testing needs (except bath and heater).
    • Ahmet prepared three combinations for Mach 1 machines, from basic to advanced based on the available features.
      • Multi-axis controller will be ideal. Multi-axis load cell or more stages will not necessarily be ordered at this time.
      • An upgrade in resolution from 0.5 micrometer to 0.1 micrometer will be an additional $4k per stage.
      • The very basic machine with a single axis controller, x-y stage, camera, tensile grips and testing chamber seem to cost around $43k.
    • A comparison for MTS Systems Corp. and Biomomentum Inc. machines was made as they are the contenders. The MTS Systems Corp. machine does not seem to be expandable. Yet, the BioRobotics Core has similar system where existing camera and controllers can be used. Training can also be bypassed.

    • Robb and Snehal will continue negotiations with Biomomentum Inc. and MTS Systems Corp. Team will also contact Biomomentum Inc. for a demonstration and other customers of Biomomentum Inc. to get feedback on the testing system.
  4. Decide tasks for the next meeting.
    • See immediate action items and notes above for details.
  5. Other.
    • None noted.

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