Recurring Meeting of Cleveland Clinic Core Team

Date: April 1, 2014

Time: 10:30 AM EST

Means: In person meeting

Attendees:

1. TBD

Agenda:

1. Discuss immediate action items from the last meeting.
2. Evaluation of readiness for mechanical joint testing.
3. Update on data management specifications (Including new in-house Midas installation).
4. Decide immediate action items for the next meeting.
5. Other.

Immediate Action Items:

• Craig
  • Provide headers of dicom files from the last imaging trial (March 20, 2014).
• Snehal
  • Setup Mach-1 mechanical testing system installation and training.
  • Redo tissue labeling details to reflect today's discussion.
• Jason
  • Continue updating pressure measurement calibration specifications.
• Snehal, Elvis, and Ahmet
  • Meet to discuss tissue sample preparation, tissue testing protocols, and constitutive modeling specifications.
• Ahmet and Robb
  • Discuss with Robb if multiple heaters at different locations can be used for temperature control.
  • Discuss documentation of gravity and inertia compensation in load transducer of robotics testing.

Notes:

1. Discuss immediate action items from the last meeting.
   • Craig provided sample images to justify the imaging specifications.
   • Ahmet is organizing the imaging specifications page. The top of the page will have the final protocol for the specifications. The notes/discussion will also be organized and/or moved to an alternate page.
   • To summarize the last imaging test session:
     • The MESE images look promising for creation of tissue geometry.
     • The T1 image sets, both with and without fat suppression, also look good and we will decide on the image resolution (isotropic versus higher in plane resolution). Likely, without fat suppression will be acquired with the isotropic field of view and with fat suppression will be acquired at a higher in plane resolution for cartilage segmentation.
   • Craig will add the headers for the example images on specifications page.
   • Cara will post her suggestions for the possible video clips to the group by the end of the day.
   • Snehal made an illustration for the sample tissue locations (Discuss in the tissue testing specifications item).
2. Evaluation of readiness for mechanical joint testing.
   • Dylan acquired a heater (for tissue testing bath) and it appears to work for the water bath though the temperature was not even across the bath. One solution may be to circulate water though this may induce error into the force/displacement measurements.
   • Another option may be to use multiple heaters at different locations and allow the bath to stabilize.
   • The brakes for the motors on the Mikrolar are still being fixed. The date for completion is being determined with the vendor.
   • Robb and Tara have worked on the gravity compensation and it was described as 70% complete though there is still some uncertainty in the results.
   • The group discussed this item and we agreed it will be beneficial to see related results to verify the compensation is robust. Ahmet will discuss with Robb this issue as it is paramount we obtain accurate joint reaction forces.
   • Jason will ask Ton about the manual knee loading rig as another alternative option.
3. Update on data management specifications (Including new in-house Midas installation).
   • Snehal rewrote the labeling convention to reflect last week's conversation.
   • The tissue types were discussed along with the convention to locate the sample.
   • Unique identifiers should be used for location (no doubling up on the same letter).
   • The meniscus will be identified as "MNS" or "MES" and the quadriceps tendon will be "QDT" or "QAT."
   • For specific tissue locations we could also use lower case letters, potentially as a sub-descriptor of the location.
   • This would be in lieu of trying to determine unique identifiers that may not have an anatomical meaning.
4. Decide immediate action items for the next meeting.
   • Immediate action items were assigned and agreed on by the group.
5. Other.
   • The Midas system was discussed and it will be tested with J2C data and the imaging trial sessions.
   • The specimen preparation needs to be worked on before the testing.
   • Jason will ask Dylan about the registration marker geometry. We should also determine centers from the imaging test session for comparison with the CAD produced centers (Craig and/or Jason will take care of this).
   • Ahmet, Elvis, and Snehal need to meet this week about tissue experimentation. Elvis arrives today. Their discussions will focus on sample preparation and infrastructure requirements.

   • Related, the BioMomentum support team (or person) will be at the Clinic next week to train Snehal on use of the tissue testing robot.