Recurring Meeting of Cleveland Clinic Core Team

Date: April 29, 2014

Time: 10:30 AM EST

Means: In person meeting

Attendees:

1. Ahmet Erdemir
2. Jason Halloran
3. Craig Bennetts
4. Snehal Chokhandre
5. Elvis Danso
6. Tara Bonner

Agenda:

1. Discuss immediate action items from the last meeting.
2. Update on joint mechanical testing.
3. Update on tissue mechanical testing.
4. Decide immediate action items for the next meeting.
5. Other.

Immediate Action Items:

• Ahmet
  • Acquire imaging information from University Hospitals imaging facility and finalize imaging specifications wiki page.
  • Update the specimen registration wiki page to reflect previous discussions.
• Snehal
  • Provide list of tissue testing accessories, fixtures, clamps in the relevant infrastructure wiki page.
  • Analyze sample pictures for thickness measurement comparisons.
• Jason
  • Finalize documentation of pressure measurement calibration; equilibration specifications are essentially complete.
  • Request updated location information for divots and spheres of patella registration marker from MDS and compare against iges and step files.
  • Compare divot and sphere locations of patella registration marker assembly.
• Craig
  • Probe points on spheres of patella registration marker from MRI data.

• Tara & Dylan

  • Complete and upload documentation on robot control and execution reproducibility.

• Jason & Robb

  • Meet to conduct actual calibration of the pressure measurement system.

Notes:

1. Discuss immediate action items from the last meeting.
   • Ahmet is waiting on input from Shannon for the imaging specifications.
   • Ahmet edited the data management specifications.
     • A Discussion page, forum entry, and contact information was added to facilitate community feedback.
     • Regarding the protocol, details for the joint, tissue, and data labeling was edited/clarified.
     • Ahmet asked the group to review, especially those involved with management of this content.
     • Details for “Data Labeling”, as the experimentation progresses, should be focused on for efficacy.
     • For data curation, the Midas platform will likely be utilized. A section for Data Dissemination was also added to document how and where the data should be stored (using SimTK downloads tool in addition to our in house Midas content tool).
   • Craig put the DICOM headers from the recent imaging trail sessions. At this point, the final editing and specs from the UH imaging center are the remaining tasks. Ahmet will complete this.
   • Snehal updated the group on the lab setup for the tissue testing machine.
     • Most, if not all, necessary items have been ordered or are in process.
     • A Windows machine is being moved to the room and keys for the room need to be picked up.
     • Furniture should be in today.
     • Snehal made a list of small items that should be in the lab (tools, personal protective equipment, etc.).
     • These items are being acquired.
     • Regarding tissue testing accessories, some are already acquired, and others are being ordered.
     • To establish the needs, Elvis and Snehal dissected an available knee last week.
     • A base plate is needed for compression.
     • Tension tests were performed and some issues were run into.
     • The bath is too small as part of the sample was not submerged.
     • Also, it's difficult to mount the specimen in such a small area.
     • Solutions were discussed, including a larger bath as well as different approaches to mounting the specimens.
     • An MCL tension specimen was tested last week.
     • The pretension was difficult to apply and the system didn't seem to apply the desired loads.
     • This troubleshooting is ongoing.
     • This week's focus will be testing with foam samples to establish the desired protocols.
     • A load to failure test will also be included for Elvis's testing.
     • For cartilage indentation, the bone pieces need to be glued to the base plate. This will be tested this week.
     • Meniscus shouldn't be a problem as Snehal has done this before.
     • What was learned, is that it easily requires two days to prepare the tissues for testing.
     • Snehal evaluated the imaged based tissue measurement. Initial results are promising but a finer gradation ruler that is made out of metal may be desirable. The ruler is slightly in front of the sample and the measurement appears to be relatively crude, but it may be adequate. Other options were discussed, including a graduated ball in plane with the sample.
   • Jason still needs to meet with Robb to finish the pressure calibration specifications. Equilibration specifications are essentially complete but pictures need to be added.
   • Ahmet and Jason need to update the specimen registration page. They will update this page to reflect their discussions.
   • Robb met with Snehal and Tony to help with the fixture designs. Updates are summarized above.
   • Craig will probe points on MRI based patella registration markers. Jason will compare sphere locations from MRI based and probed divots. This should give an indication of the experiment to image registration accuracy.
   • Dylan will complete and upload documentation for robot control and execution reproducibility.
   • Ahmet asks everyone to look at the specimen preparation page for a gross review. If the group does this then we can go through this point by point in a future meeting and/or all agree that this is an acceptable approach. One note, Snehal should add more information for the preparation of the specimens for mechanical testing.
2. Update on joint mechanical testing.
   • Tara updated the group on the mechanical testing setup.
   • She feels having the new motor issues will help but this is yet to be determined.
   • The current testing with another group is working but it could be smoother.
   • The group discussed developing a testing protocol that could be used to verify the robot's performance after major changes to the hardware.
3. Update on tissue mechanical testing.
   • See discussions in item 1.
4. Decide immediate action items for the next meeting.
   • Immediate action items were agreed on.
5. Other.
   • Ahmet and Jason met with the Utah group. They (Utah) submitted an abstract to CMBBE with the new zero strain feature in FEBio.