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  *   * An editorial type of an article about Open Knee(s) was published in Orthopaedic Insights, the newsletter of the Department of Orthopaedic Surgery, Cleveland Clinic:
  . Erdemir, A. And Jones, M. (2015) Open Knee(s) project: using crowdsourcing to harness community
insight and clinical expertise to revolutionize knee modeling, Orthopaedic Insights (Winter 2014-2015),
A Physician Newsletter from the Department of Orthopaedic Surgery, Cleveland Clinic.
  . [http://consultqd.clevelandclinic.org/2015/03/using-crowdsourcing-to-revolutionize-knee-modeling/ Using crowdsourcing to revolutionize knee modeling]
  * Dissemination of image sets for Open Knee(s) - Generation 2 was promoted in Biomch-L forums:
  . [http://biomch-l.isbweb.org/threads/27781-Imaging-data-for-Open-Knee%28s%29-Generation-2-specimens]
  * Ahmet presented Open Knee(s) project at the University of Missouri, Columbia, MO.
  . Erdemir, A., Open Knee(s): a path towards open source virtual musculoskeletal joints, March 18, 2015, Departments of Bioengineering and Mechanical Engineering, University of Missouri, Columbia, MO.
  . https://simtk.org/svn/openknee/doc/mizzou_2015.pdf

Recurring Meeting of the Advisory Board

Date(s): May 8-21, 2015

Due to scheduling conflicts, the group meeting with the Advisory Board members were scheduled on an individual basis with each member. Please refer to Meeting Minutes for more details.

TableOfContents

Progress Report

Project Specific Aims

  • To provide an open, freely available, and collaborative development, testing, simulation and dissemination platform for in silico exploration of the biomechanics of healthy and diseased knees.
  • To develop in silico biomechanical models of healthy and diseased knee joints of different genders and ages, supported by specimen-specific joint and tissue level experimental mechanics.

Project Infrastructure

Project Contact

Advisory Board

  • Clinical. Jack Andrish, MD; Carl Winalski, MD; Morgan Jones, MD, MPH; Paul Saluan, MD (Cleveland Clinic)

  • Engineering. Yasin Dhaher, PhD (Northwestern University); Trent Guess, PhD (University of Missouri), Rami Korhonen, PhD (University of Eastern Finland)

Progress Period

  • November 20, 2014 - May 8, 2015

Development Team during Progress Period

  • Cleveland Clinic Core Team. Craig Bennetts, Tara Bonner, Snehal Chokhandre, Robb Colbrunn, Ahmet Erdemir

  • Stanford University. Scott Delp, Joy Ku, Henry Kwong

  • University of Utah. Ben Ellis, Jeff Weiss, Steve Maas

  • Community. Shannon Donnola, Chris Flask

See https://simtk.org/project/xml/team.xml?group_id=485 for full details on the project team.

Goals of Progress Period

  • Launch and enhance web based computation infrastructure (Stanford University)
  • Implement additional features in simulation software (University of Utah)
  • Disseminate joint imaging and joint mechanics data for oks001, oks002, oks004 (Cleveland Clinic)
  • Complete joint imaging and joint mechanics experimentation on oks003, oks005, oks006, oks007 (Cleveland Clinic)
  • Complete tissue mechanics testing of oks001, oks002, oks004 (Cleveland Clinic)

  • Continue development and review of modeling & simulation specifications (Cleveland Clinic & Community)

  • Start developing models for oks001, oks002, oks004 (Cleveland Clinic)
  • Upgrade and disseminate Open Knee(s) - Generation 1 (Cleveland Clinic)

  • Implement 2015 summer internship program as part of community projects (Cleveland Clinic & Community)

  • Publish previous work on Open Knee - Generation 1 (Cleveland Clinic)

Please also refer to previous meeting minutes of the Advisory Board at ["RecurringMeetings/2014-11-20"]. It should be noted that the timeline of activities has deviated from the original proposal, i.e., see the ["Roadmap"] and the proposed timeline of the proposal in attachment:GrantInformation/proposal.pdf.

Activities of Progress Period

  • Cloud computing prototype

    • Cleveland Clinic and Stanford University teams continued to have bi-monthly conference calls to discuss web based computation interface. Please refer to meeting minutes in Cleveland Clinic - Stanford University section of ["RecurringMeetings"].

    • Detailed specifications on a prototype for web-based computing infrastructure can be found at the wiki page [http://wiki.simtk.org/openknee/Specifications/CloudComputingPrototype?action=recall&rev=19 Revision as of May 6, 2015] or [:Specifications/CloudComputingPrototype: current version].

    • The team at the Stanford University mainly focused on the upgrade of the SimTk.org infrastructure. The launch of the updated site has been delayed.

    • In the previous progress report, it was noted that web-based interfaces for submissions of simulations and for results retrieval had been implemented and tested on a staging server. The team has been waiting for SimTk.org upgrade for the public release of the cloud computing interface. In following, usability testing of the infrastructure can be performed.

    • Following usability testing (anticipated to happen after the launch of updated SimTk.org site], the development of a model administration interface and the implementation of quota management features will be conducted.

    • The Cleveland Clinic team applied for a hardware grant from a commercial company with the intention to provide a dedicated high performance computing infrastructure for Open Knee(s). The application was not successful.
  • Simulation software features

    • Cleveland Clinic and University of Utah teams continued to have monthly conference calls to discuss enhancements in FEBio, the simulation software used in Open Knee(s). Please refer to meeting minutes in Cleveland Clinic - University of Utah section of ["RecurringMeetings"].

    • Detailed specifications for desired features can be found at the wiki page [http://wiki.simtk.org/openknee/Specifications/FebioFeatures?action=recall&rev=41 Revision as of May 8, 2015] or [:Specifications/FebioFeatures: current version].

    • Studies for implementing and testing in situ ligament strain feature advanced. A manuscript is under development.
    • Feature set definitions are ready for continued testing. To support model parametrization and scripting, a new feature to accommodate splitting and combining model files was implemented.
    • Rigid body movement related features, e.g. definition of cylindrical joints to represent anatomical joint coordinate systems and movement conventions, are primarily explored by Gerard Ateshian, co-lead of FEBio development team.
  • Experimentation

  • Modeling & simulation

    • Open Knee(s) - Generation 1 model, which was upgraded to work with FEBio version 2.0, was disseminated (see item on Dissemination below).
    • Many modeling and simulation studies as use cases has been started to illustrate the utility of knee joint models and to explore the capabilities of Open Knee(s) - Generation 1:

    • The work to expand upon the outlines of various modeling & simulation specifications was postponed, awaiting for summer interns (described in the item below on Community Projects).

  • Dissemination

    • As of April 8, 2015, Open Knee(s) provided 2 release packages, Open Knee - Generation 1 versions g1-s1-v1.1.0.391 & g1-s1-v1.0.1.202. The new release, g1-s1-v1.1.0.391, is an updated model compatible with FEBio v2.1.2.6432 and above. Total downloads for all Open Knee – Generation 1 versions is 806 (582 unique downloads) as of April 8, 2015, see [https://simtk.org/project/xml/downloads.xml?group_id=485 Open Knee(s) download page].

    • As of May 8, 2015, Open Knee(s) provided 5 developer, 3 user documentation in release form, see [https://simtk.org/docman/?group_id=485 Open Knee(s) documents page].

    • With a few exceptions (as requested by a collaborating team), all of the project website; wiki site, e.g. specifications, meeting minutes; and source code repository are publicly accessible.

    • As of June 7, 2015, Open Knee(s) website received 130,067 page hits in the past 180 days with 24,348 unique visitors, see [https://simtk.org/project/stats/usagemap.php?group_id=485 Open Knee(s) project activity].

    • As of May 8, 2015, Open Knee(s) enabled 12 studies by external research teams, see [https://simtk.org/project/xml/publications.xml/?group_id=485 Open Knee(s) publications page].

    • At this moment joint imaging and mechanical testing data are available for six knees, oks001, oks002, oks003, oks004, oks006, oks007. Joint imaging data were disseminated (see [https://simtk.org/project/xml/downloads.xml?group_id=485 Open Knee(s) download page]), dissemination of mechanical testing data sets is pending, following organization of the information.

  • Community projects
  • Publications
    • A manuscript on Open Knee - Generation 1 was submitted to a special issue of Journal for Knee Surgery organized by Trent Guess and Jimi Cook.
    • Various abstracts were submitted to conferences for upcoming presentations in the next progress period:
      • Overview of the whole experimentation workflow with some example data was submitted to 2015 BMES/FDA Frontiers in Medical Devices Conference: Innovations in Modeling and Simulation, May 18-20, 2015, Washington DC.
      • Anatomical imaging and tibiofemoral joint testing studies were submitted to Summer Biomechanics, Bioengineering, and Biotransport Conference, June 17-20, 2015, Snowbird, UT as two different studies.
      • Patellofemoral joint testing study was submitted to 39th Annual Meeting of the American Society of Biomechanics,

August 5-8, 2015, Columbus, OH.

  • Other
    • An editorial type of an article about Open Knee(s) was published in Orthopaedic Insights, the newsletter of the Department of Orthopaedic Surgery, Cleveland Clinic:
    • Erdemir, A. And Jones, M. (2015) Open Knee(s) project: using crowdsourcing to harness community

insight and clinical expertise to revolutionize knee modeling, Orthopaedic Insights (Winter 2014-2015), A Physician Newsletter from the Department of Orthopaedic Surgery, Cleveland Clinic.

Details of activities can be found in past meeting minutes of various teams at ["RecurringMeetings"].

Plans for Next Progress Period (May 8, 2015 - November 2014)

It should be noted that the timeline of activities has deviated from the original proposal, i.e., see the ["Roadmap"] and the proposed timeline of the proposal in attachment:GrantInformation/proposal.pdf.

Meeting Minutes

Date, Time, Means:

  • May 8, 2015, 11:00 AM EST, in person meeting (AE,CB,SC,JA,MJ,YD)
  • May 8, 2015, 4:00 PM EST, conference call (TG)
  • May 21, 2015, 9:00 AM EST, conference call (RK)
  • May 21, 2015, 12:00 PM EST, in person meeting (PS)

Attendees:

  1. Ahmet Erdemir (Cleveland Clinic)
  2. Craig Bennetts (Cleveland Clinic)
  3. Snehal Chokhandre (Cleveland Clinic)
  4. Jack Andrish (Cleveland Clinic)
  5. Morgan Jones (Cleveland Clinic)
  6. Paul Saluan (Cleveland Clinic)
  7. Yasin Dhaher (Northwestern University)
  8. Trent Guess (University of Missouri)
  9. Rami Korhonen (University of Eastern Finland)

Agenda:

  1. Progress update, see progress report at:
  2. Recap of previous meeting minutes, see meeting minutes at:
  3. Action items for following meeting.
  4. Other.

Immediate Action Items:

See notes for details.

  • All Advisory Board Members

    • TBD

  • Ahmet Erdemir

    • TBD

Notes:

  1. Due to scheduling conflicts, a series of meetings were conducted to inform the Advisory Board about Open Knee(s) activities and get feedback.
  2. Progress update.
    • TBD
  3. Recap of previous meeting minutes.
    • TBD
  4. Action items for following meeting.
    • See Immediate Action Items above.
  5. Other.
    • TBD

RecurringMeetings/2015-05-08 (last edited 2016-05-04 22:09:51 by localhost)