Recurring Meeting of the Advisory Board

Date(s): Nov 19 - , 2015

Due to scheduling conflicts, the group meeting with the Advisory Board members were scheduled on an individual basis with each member. Please refer to Meeting Minutes for more details.

TableOfContents

Progress Report

Project Specific Aims

• To provide an open, freely available, and collaborative development, testing, simulation and dissemination platform for in silico exploration of the biomechanics of healthy and diseased knees.
• To develop in silico biomechanical models of healthy and diseased knee joints of different genders and ages, supported by specimen-specific joint and tissue level experimental mechanics.

Project Infrastructure

• https://simtk.org/home/openknee (project website)

• http://wiki.simtk.org/openknee (project wiki)

Project Contact

• Ahmet Erdemir, PhD, erdemira@ccf.org, https://simtk.org/users/aerdemir

Advisory Board

• Clinical. Jack Andrish, MD; Carl Winalski, MD; Morgan Jones, MD, MPH; Paul Saluan, MD (Cleveland Clinic)

• Engineering. Yasin Dhaher, PhD (Northwestern University); Trent Guess, PhD (University of Missouri), Rami Korhonen, PhD (University of Eastern Finland)

Progress Period

• May 9, 2015 - November 19, 2015

Development Team during Progress Period

• Cleveland Clinic Core Team. Craig Bennetts, Tara Bonner, Snehal Chokhandre, Robb Colbrunn, Ahmet Erdemir

• Stanford University. Scott Delp, Joy Ku, Henry Kwong

• University of Utah. Ben Ellis, Jeff Weiss, Steve Maas

• Community. Shannon Donnola, Chris Flask, Omar Gad, Raghav Malik, Diana Suciu, Connor Lough

See https://simtk.org/project/xml/team.xml?group_id=485 for full details on the project team.

Goals of Progress Period

• Launch and test usability of web based computation infrastructure (Stanford University)
• Publish in situ strain feature and implement additional features in simulation software (University of Utah)
• Disseminate joint mechanics data for oks001, oks002, oks003, oks004, oks006, oks007 (Cleveland Clinic)
• Complete joint imaging and joint mechanics experimentation on oks008, oks009, oks010, oks011 (Cleveland Clinic)
• Start tissue mechanics testing of all specimens (Cleveland Clinic)

• Continue development and review of modeling & simulation specifications (Cleveland Clinic & Community)

• Start developing models for all specimens (Cleveland Clinic)
• Follow up publication of previous work on Open Knee - Generation 1 (Cleveland Clinic)

Please also refer to previous meeting minutes of the Advisory Board at ["RecurringMeetings/2015-05-08"]. It should be noted that the timeline of activities has deviated from the original proposal, i.e., see the ["Roadmap"] and the proposed timeline of the proposal in attachment:GrantInformation/proposal.pdf.

Activities of Progress Period

• Cloud computing prototype

  • The team at the Stanford University mainly focused on the upgrade of the SimTk.org infrastructure. Internal testing of the updated site has been taking longer than expected. As a result, the launch of the updated site has been delayed. With the upgrade of !Simtk.org, a beta release of the cloud computing infrastructure will be launched for usability testing. Cleveland Clinic team has Open Knee(s) - Generation 1 model ready with pre- and post-processing scripts for the beta release. The usability testing will facilitate the development of a model administration interface and the implementation of quota management features.

  • Cleveland Clinic and Stanford University teams cancelled majority of the conference calls, awaiting upgrade of SimTk.org and launch of Open Knee(s) cloud computing beta release. For those which were held, please refer to meeting minutes in Cleveland Clinic - Stanford University section of ["RecurringMeetings"].

  • Detailed specifications on a prototype for web-based computing infrastructure can be found at the wiki page [http://wiki.simtk.org/openknee/Specifications/CloudComputingPrototype?action=recall&rev=19 Revision as of November 17, 2015] or [:Specifications/CloudComputingPrototype: current version].

• Simulation software features

  • Cleveland Clinic and University of Utah teams continued to have monthly conference calls to discuss enhancements in FEBio, the simulation software used in Open Knee(s). Please refer to meeting minutes in Cleveland Clinic - University of Utah section of ["RecurringMeetings"].

  • Detailed specifications for desired features can be found at the wiki page [http://wiki.simtk.org/openknee/Specifications/FebioFeatures?action=recall&rev=41 Revision as of November 17, 2015] or [:Specifications/FebioFeatures: current version].

  • Studies for implementing and testing in situ ligament strain feature has completed. A manuscript was submitted to the Journal of the Mechanical Behaviour of Biomedical Materials for publication.
  • Rigid body movement related features, e.g. definition of cylindrical joints to represent anatomical joint coordinate systems and movement conventions, were implemented and ready for continued testing.
  • Future efforts will likely build upon the implemented set definitions feature to allow definition of parts/components for assembly of models.
  • Overall, FEBio team has implemented many critical features for modeling and simulation of musculoskeletal joints. Additional work will likely focus on testing and evaluation of these features and implementation of convenience features to facilitate modeling workflow.
• Experimentation

• Modeling & simulation
• Dissemination

  • As of November 17, 2015, Open Knee(s) provided 8 packages (1,834 total downloads, 950 unique downloads), see [https://simtk.org/project/xml/downloads.xml?group_id=485 Open Knee(s) download page]:

    • oks001 version g2-s1-v0.2.0.20150825 (72 unique users as of November 17, 2015)
    • oks002 version (14 unique users as of November 17, 2015)
    • oks003 version (8 unique users as of November 17, 2015)
    • oks004 version (8 unique users as of November 17, 2015)
    • oks006 version (6 unique users as of November 17, 2015)
    • oks007 version (9 unique users as of November 17, 2015)
    • oks008 version (11 unique users as of November 17, 2015)

    • Open Knee - Generation 1 versions g1-s1-v1.1.0.391 & g1-s1-v1.0.1.202 (617 unique users as of November 17, 2015):

  • As of November 17, 2015, Open Knee(s) provided 5 developer, 3 user documentation in release form, see [https://simtk.org/docman/?group_id=485 Open Knee(s) documents page].

  • With a few exceptions (as requested by a collaborating team), all of the project website; wiki site, e.g. specifications, meeting minutes; and source code repository are publicly accessible.

  • As of November 17, 2015, Open Knee(s) website received 111,769 page hits in the past 180 days with 19,572 unique visitors, see [https://simtk.org/project/stats/usagemap.php?group_id=485 Open Knee(s) project activity].

  • As of November 17, 2015, Open Knee(s) enabled 17 studies by external research teams, see [https://simtk.org/project/xml/publications.xml/?group_id=485 Open Knee(s) publications page].

  • At this moment joint imaging and mechanical testing data are disseminated for seven knees: oks001, oks002, oks003, oks004, oks006, oks007 & oks008 (see [https://simtk.org/project/xml/downloads.xml?group_id=485 Open Knee(s) download page]).

• Community projects
• Publications
• Other

Details of activities can be found in past meeting minutes of various teams at ["RecurringMeetings"].

Plans for Next Progress Period (November 20, 2015 - May 2015)

• Launch and test usability of web based computation infrastructure (Stanford University)
• Explore the possibility to implement additional convenience related features in simulation software (University of Utah)
• Complete joint imaging and joint mechanics experimentation on oks009, oks010, oks011 (Cleveland Clinic)
• Start tissue mechanics testing of all specimens (Cleveland Clinic)

• Continue development and review of modeling & simulation specifications (Cleveland Clinic & Community)

• Continue developing models for all specimens (Cleveland Clinic)

• Plan 2016 summer internship program as part of community projects (Cleveland Clinic & Community)

• Follow up with case studies on modeling & simulation (Cleveland Clinic & Community)

• Follow up publications for Open Knee(s) - Generation 2 data sets (Cleveland Clinic)

It should be noted that the timeline of activities has deviated from the original proposal, i.e., see the ["Roadmap"] and the proposed timeline of the proposal in attachment:GrantInformation/proposal.pdf.

Meeting Minutes

Date, Time, Means:

• TBD

Attendees:

1. TBD

Agenda:

1. Progress update, see progress report at:

   • http://wiki.simtk.org/openknee/RecurringMeetings/2015-11-19

2. Recap of previous meeting minutes, see meeting minutes at:

   • http://wiki.simtk.org/openknee/RecurringMeetings/2015-05-08

3. Action items for following meeting.
4. Other.

Immediate Action Items:

See notes for details.

• All Advisory Board Members

  • TBD

• Ahmet Erdemir

  • TBD

Notes:

1. Due to scheduling conflicts, a series of meetings were conducted to inform the Advisory Board about Open Knee(s) activities and get feedback.
2. Progress update.
   • TBD
3. Recap of previous meeting minutes.
   • TBD
4. Action items for following meeting.
   • See Immediate Action Items above.
5. Other.
   • TBD