Recurring Meeting of Cleveland Clinic Core Team

Date: December 8, 2015

Time: 10:30 AM EST

Means: In person meeting

Attendees:

1. Ahmet Erdemir
2. Craig Bennetts
3. Snehal Chokhandre
4. Robb Colbrunn
5. Tara Bonner
6. Jason Halloran (Cleveland State University)
7. Will Zaylor (Cleveland State University)

Agenda:

1. Discuss immediate action items from the last meeting.
2. Discuss tissue testing protocol evaluation progress.
3. Decide immediate action items for the next meeting.
4. Other.

Immediate Action Items:

• Ahmet
  • Continue working on accumulating segmentation and geometry generation specifications.
  • Disseminate oks009 joint mechanics data.
• Craig
  • Add pictures to image segmentation specification documentation.
  • Provide sample MRI on oks009 specimen page.
• Snehal
  • Complete Python script to assemble ramp and relaxation parts of tissue testing data and get instantaneous and equilibrium modulus.
  • Test the new high resolution load cells on Mach-1 testing system.
• Tara
  • Continue filling in the manuscript in response to reviewed list of paragraphs and figures and tables for imaging data manuscript.
• Robb
  • Continue working on paragraphs for the remaining sections of the patellofemoral joint testing manuscript and add a list of figures and tables.

Ongoing Action Items:

DEADLINE FOR FIRST COMPLETE DRAFTS FOR DATA PAPERS IS JAN 12, 2016

• Ahmet
  • Prepare flowcharts to describe data flow for pre-processing of joint kinematics/kinetics data.
• Craig
  • Anatomical imaging manuscript.
  • Large-scale analysis of simulation parameters for convergence.
• Snehal
  • Add citations and summaries to tissue data papers to the wiki for potential use to model tissue properties.
  • Work on Python scripting to process tissue testing data.
  • Pivot shift manuscript.

  • Cruciate ligament modeling & simulation.

• Robb
  • Patellofemoral joint experimentation manuscript.
• Tara
  • Tibiofemoral joint experimentation manuscript.

Notes:

1. Discuss immediate action items from the last meeting.
   • Ahmet disseminated oks009 MRI data. During organization of oks009 joint mechanics data, he realized that processed files to represent the specimen, which is a left knee, in physical space were not available. He informed Robb and Tara to provide these. Robb and Tara noted that they already uploaded an updated zip file to the in-house data management system to address this issue. Ahmet did not work on accumulating segmentation and geometry generation specifications other than having discussions with Craig.
   • Craig continued segmentation of ligaments from oks001 MRI. The segmentation process is mostly manual. First, a gross manual segmentation on ligament specific MR images is performed. These images provide an appropriate in-plane resolution but due to large thickness of the images the out-of-plane resolution is undesirable. Therefore, a second manual segmentation step is performed on higher resolution cartilage specific MR images by loading the initial gross segmentation to use as a guide. For oks001, segmentation of MCL and menisci is remaining. Craig will need to document his workflow in the image segmentation specifications. He still needs to provide sample MR images for oks009.
   • In response to Craig, Ahmet described the meshing steps following segmentation. The first step is to see if the raw segmentation boundaries for each tissue can be processed, e.g. smoothed, and meshed using tetrahedral elements. Depending on the mismatch of shared boundaries between tissues, e.g. bone and cartilage, segmentation workflow may need to be adjusted depending on geometric modeling and meshing requirements.
2. Discuss tissue testing protocol evaluation progress.
   • TBD
3. Decide immediate action items for the next meeting.
   • TBD
4. Other.
   • TBD