• RecurringMeetings
• 2016-08-30

Recurring Meeting of Cleveland Clinic Core Team

Date: August 30, 2016

Time: 10:30 AM EST

Means: In person meeting

Attendees:

1. Ahmet Erdemir
2. Snehal Chokhandre
3. Robb Colbrunn
4. Tara Bonner

Agenda:

1. Discuss immediate action items from the last meeting.
2. Discuss progress of tissue testing protocol evaluation.
3. Discuss progress of joint testing and imaging data manuscripts.
4. Discuss segmentation plan and progress.
5. Decide immediate action items for the next meeting.
6. Other.

Immediate Action Items:

• Ahmet (ongoing)
  • Complete reviewing the drafts of data manuscripts.
• Snehal (ongoing)
  • Work on reproducibility testing of confined compression.
  • Continue reproducibility testing of tension tests.
  • Implement zero stress-strain estimation to tissue testing analysis code.
• All (ongoing)
  • Continue segmentation based on commitments listed in the Roadmap.

Notes:

1. Discuss immediate action items from the last meeting.
   • Ahmet mentioned that many of the action items are ongoing. Currently, they are specifically related to work on data manuscripts, tissue testing, and segmentation. He also noted that upcoming ongoing activities include model development and simulations.
   • In response to Robb's request, Ahmet went over the whole modeling and simulation work and expected work within the Open Knee(s) funding period.
   • Ahmet asked team members whether they would like to have weekly meetings. Snehal recommended to keep the meetings as she found them useful for discussing ongoing activities. The meetings will continue as scheduled.
   • Most action items were related to the agenda items; refer to discussions below.
2. Discuss progress of tissue testing protocol evaluation.
   • Snehal has had troubles getting the reproducibility of confined compression and tension testing using tissue samples. After discussions from previous meetings it was decided that rubber samples will be tested first using higher 'find contact' load and higher preconditioning strain. Snehal tested a rubber samples twice without taking the sample out of the set up with 5 hours between tests (both 'find contact' and stress relaxation protocols were repeated). It appears through visual inspection of the data that the rubber tensile test is repeatable. Snehal mentioned that from looking at tissue repeatability data that it appears that filtering at 100hz may not be adequate. Ahmet suggested that as the ramps take 0.25 sec the data can be filtered at anything more than 4/5 hz. Snehal will repeat the tensile test for a tissue sample this week. Snehal also updated the data analysis script to find the zero load-disp point from the 'find contact' segment instead of picking the point at which the load is 5g/10g. Five times the load cell resolution is used as the threshold.
3. Discuss progress of joint testing and imaging data manuscripts.
   • Ahmet did not have any progress on the manuscripts.
4. Discuss segmentation plan and progress.
   • Robb asked about matching of the boundaries of the bone and cartilage. Ahmet noted that this may not be that important as long as the analyst has a good faith effort to identify back surface of the cartilage. The smoothing will likely causes mismatches between overlapping cartilage and bone surfaces. The analyst should be more careful about cartilage segmentation as errors may highly influence cartilage thickness representation. Bones will be modeled as rigid bodies; the segmentation will essentially provide a visual representation. To connect cartilage to bone, different strategies exist, which are forgiving when the surfaces do not match exactly.
   • Tara mentioned that she segmented medial meniscus instead of lateral. She updated the roadmap accordingly.
   • Tara also noted the possibility to have a few high school students to work on segmentation.
5. Decide immediate action items for the next meeting.
   • Many action items are ongoing, requiring steady work on manuscripts, tissue testing, segmentation, and model development. They will be discussed as such in upcoming meetings.
6. Other.
   • Ahmet mentioned that he has been working with the team at Stanford University for launching cloud computing for Open Knee(s).