• RecurringMeetings
• 2016-12-06

Recurring Meeting of Cleveland Clinic Core Team

Date: December 6, 2016

Time: 10:30 AM EST

Means: In person meeting

Attendees:

1. Ahmet Erdemir
2. Snehal Chokhandre
3. Robb Colbrunn
4. Tara Bonner

Agenda:

1. Discuss immediate action items from the last meeting.
2. Discuss progress of tissue testing protocol evaluation.
3. Discuss segmentation progress.
4. Decide immediate action items for the next meeting.
5. Other.

Ongoing Action Items:

• Ahmet
  • Complete reviewing the drafts of data manuscripts.
• Snehal
  • Snehal will explore more literature on meniscus testing.
  • Continue filling in the dashboard for tissue testing reproducibility.
• All
  • Continue segmentation based on commitments listed in the Roadmap.

Notes:

1. Discuss immediate action items from the last meeting.
   • Most action items were related to the ongoing agenda items; refer to discussions below.
2. Discuss progress of tissue testing protocol evaluation.
   • Snehal continued meniscus testing. She was working on testing with consistent minimization of swelling. Pre-conditioning was also changed 5 to 15%. Thickness measurements seemed to vary. Meniscus unconfined compression continued to be problematic.
   • Snehal did another experiment with the meniscus. First test as usual; the second test started at the initial position of the first test, the response was not similar.
   • Snehal did not contact the authors of meniscus testing with and without swelling for confined test. She was able to reproduce their results qualitatively in that swelling had a similar influence (less stiff) on the tissue. She will look at the data quantitatively.
   • Snehal also worked on tensile testing of tendon. Gripping was an issue. She tried new gripping strategy (with gauze and gluing); while the results were better; gripping effects were observable. She later did tests by decreasing target load to 4.5% rather than 6%; which did not resolve the problems. She decreased the strain rate to 10%/s rather 20%/s; repeatability enhanced. She then increased pre-conditioning cycle numbers to 2,000 and tested at 10%/s to 4.5%; similar results were obtained. Snehal will explore repeatability at lower strain rates (1%/s); she will adjust pre-conditioning rates accordingly - doing the test 20 times slower than originally planned.
   • Pre-conditioning data sometimes exhibit unexpected behavior; this may be used for quality assurance.
   • Ahmet also advised to potentially start testing of Open Knee(s) specimens for tissues and testing types that exhibited satisfactory repeatability.
3. Discuss segmentation progress.
   • Robb had trouble with oks004 due to general purpose imaging coordinate system seemed to be shifted. Ahmet recommended him to use other imaging modalities to segment bone.
4. Decide immediate action items for the next meeting.
   • See Ongoing Action Items above.
5. Other.
   • Ahmet recommended to move Robb and Tara's effort levels from the Open Knee(s) for the first quarter of 2017. On a need basis, their assistance will be requested for segmentation and data analysis.