Weekly Update in lieu of Recurring Meeting of Cleveland Clinic Core Team

Date: April 4, 2017

Provided by: Snehal Chokhandre

Ongoing Action Items:


  1. Tissue testing.
    • Snehal completed multiple day testing for two cartilage samples under unconfined compression. The tests were conducted in PBS and with ~24 hours between each test for a given sample. These two samples were taken from neighbouring locations. It appears that the combination of PBS and adequate resting time between tests aids in recovery of the sample resulting in a more repeatable behavior over 5 days. The repeatability error is ~6% for sample 1 and ~8% for sample 2. These tests were conducted without the updated preconditioning protocol.
    • Snehal is currently conducting another set of week long tests for two cartilage samples but with the updated protocol with ramp load-unload before and after the preconditioning.
    • Next week Snehal will assess the effect of freezing on the repeatability of cartilage sample behavior. Similar set of tests will be conducted on another set of samples (not previously tested).
    • There does not appear to be any trend in data that may indicate deterioration of tissues over multiple days. The cartilage samples were stored in the fridge soaked in PBS at all times when not actually being tested. The tests are conducted at room temperature.
  2. Data manuscripts.
    • No progress.
  3. Segmentation.
    • No progress.
  4. Other.
    • Snehal and Ahmet met and discussed the potential modeling and simulation work Snehal will be conducting. Ahmet suggested that Snehal should create a new case study with a detailed justification of the technical and/or scientific requirement of the proposed study (need for the study, need for modeling, value of the proposed study, assessment of credibility of model, predictions compared to literature, modeling challenges etc).
    • Snehal and Ahmet will meet every two weeks on Tuesdays to discuss the progress of modeling and simulation both for the case study and for the overall progress of Open Knee(s).
    • Ahmet also suggested Snehal to keep track of hours spend on modeling and compare the estimate to the actual time needed. This will help understand the economic burden of modeling and simulation.

RecurringMeetings/2017-04-04-Update (last edited 2017-04-10 14:10:08 by aerdemir)