Weekly Update in lieu of Recurring Meeting of Cleveland Clinic Core Team
Date: May 30, 2017
Provided by: Snehal Chokhandre
Ongoing Action Items:
- Review drafts of data manuscripts for submission.
- Complete studies for tissue testing reproducibility.
- Continue tissue testing of Open Knee(s) specimens.
- Continue segmentation of Open Knee(s) specimens.
- Tissue testing.
Snehal completed cartilage confined compression test set (5 tests over 5 day) for the 48 year old specimen. The first three tests were fairly repeatable at higher strains, though at lower strains there was >15% error. The last two tests varied significantly. Since the change is not in one direction, i.e., monotonously increasing or decreasing stresses from trial to trial, Ahmet speculated that this may not be due to the tissue and some other random factor might be affecting the variability.
- To assess whether the filter tipping or catching along the confined compression test chamber may be responsible for the variation, Snehal will run a test set with no filter (with 3mm diameter indenter) and without removing the sample from the chamber between tests (to keep test conditions as constant as possible).
- Snehal is also working on streamlining tissue data analysis and making the scripts modular.
- Data manuscripts.
- No progress.
- No progress.
- Snehal is currently segmenting patella cartilage for oks001 and will use this segmentation and that done by Craig to build surfaces and geometries using the exact same protocols. Simple indentation tests will be done on these two cartilage geometries.
Ahmet and Snehal also discussed OpenKnee(s) work plan for the next year and have decided that segmentation efforts will have to be ramped-up along with tissue testing. Snehal will take upon segmentation responsibility in parallel with tissue testing. With all the geometries segmented, models can be rapidly built when necessary.
- By the end of August 2017, Snehal and Ahmet will decide whether to prioritize tissue testing or segmentation depending on the progress made with tissue data repeatability tests. Until then Snehal will populate segmentation database depending on the time she can dedicate to tissue testing.
- Ahmet has been interacting with Cobus Muller, Swithin Razu, and Trent Guess. They have been using oks001 data to build a patellofemoral joint model. Supported by discussions with Ahmet, the team has been navigating successfully through the analysis of kinematics data collected on the patellofemoral joint.