Open Knee(s) targets for development of knee models with a predictive capacity for joint mechanics and tissue mechanics. Finite element analysis is the simulation tool of choice as it has the premise to provide detailed quantification of knee biomechanics. Detailed specifications for required experimentation and modeling & simulation steps are provided in through the links below.

Modeling & simulation within the Open Knee(s) project relies on:

• a general purpose workflow summarized in https://simtk.org/websvn/wsvn/openknee/doc/FEA-workflow.pdf

• a description of the components of a finite element analysis study provided in https://simtk.org/websvn/wsvn/openknee/doc/msm_2015.pdf

All Specifications Pages

Experimentation Workflow

The following relates the above flowchart to the corresponding specification page(s). Note the step numbers in the flowchart correspond to the specification pages below. Both this list and the flowchart should be updated if the workflow changes. Pages for specific information on each step of the experimentation process are:

1. Specifications/Specimens

2. Specifications/SpecimenPreparation

   1. Initial preparation
   2. Preparation for registration
   3. Preparation for anatomical imaging
   4. Preparation for joint testing
   5. Preparation for tissue testing
   6. Supporting Specifications:

   7. Specifications/DataManagement

3. Specifications/ExperimentationAnatomicalImaging

   1. Output: magnetic resonance images for specimen-specific anatomical reconstruction
   2. Supporting Specifications:

   3. Specifications/DataManagement

   4. Specifications/MRIScoring

4. Specifications/ExperimentationJointMechanics

   1. Output: in vitro joint mechanics (kinematics-kinetics response)
   2. Supporting Specifications:

   3. Specifications/DataManagement

   4. Specifications/PressureCalibration

5. Specifications/ExperimentationTissueMechanics

   1. Output: in vitro tissue mechanics (stress-strain response)
   2. Supporting Specifications:

   3. Specifications/DataManagement

   4. Specifications/ExperimentationTissueThickness

6. Specifications/Registration

   1. Output: coordinate system transformations (between imaging and experimentation systems)

Modeling & Simulation Workflow

The following list relates the modeling and simulation flowchart above to the corresponding specification pages. Both the list and the flowchart should be updated if the workflow changes. The step numbers in the flowchart correspond to the specification pages as listed:

1. Prerequisite experimentation

   1. Specifications/ExperimentationAnatomicalImaging

   2. Specifications/ExperimentationTissueMechanics

   3. Specifications/ExperimentationJointMechanics

2. Specifications/ImageSegmentation

3. Specifications/GeometryGeneration

4. Specifications/MeshGeneration

5. Specifications/ModelingConstitutive

6. Specifications/ModelingTissue

7. Specifications/SimulationTissue

   1. Output: specimen specific predictions of tissue mechanics
   2. Supporting Specifications:

   3. Specifications/CloudComputingPrototype

   4. Specifications/FebioFeatures

8. Specifications/MeshAssembly

   • Supporting Specifications:

   • Specifications/ModelingModelGraph

9. Specifications/ModelingAssembly

   • Supporting Specifications:

   • Specifications/ModelingModelGraph

10. Specifications/ModelingCompartmental

11. Specifications/SimulationCompartmental

    1. Output: specimen specific predictions of compartmental mechanics
    2. Supporting Specifications:

    3. Specifications/ModelingKinematicsKinetics

    4. Specifications/CloudComputingPrototype

    5. Specifications/FebioFeatures

12. Specifications/ModelingJoint

13. Specifications/SimulationJoint

    1. Output: specimen specific predictions of joint mechanics
    2. Supporting Specifications:

    3. Specifications/ModelingKinematicsKinetics

    4. Specifications/PressureAnalysis

    5. Specifications/CloudComputingPrototype

    6. Specifications/FebioFeatures