Open Knee(s) targets for development of knee models with a predictive capacity for joint mechanics and tissue mechanics. Finite element analysis is the simulation tool of choice as it has the premise to provide detailed quantification of knee biomechanics. Detailed specifications for required experimentation and modeling & simulation steps are provided in through the links below.

Modeling & simulation within the Open Knee(s) project relies on:

• a general purpose workflow summarized in https://simtk.org/websvn/wsvn/openknee/doc/FEA-workflow.pdf

• a description of the components of a finite element analysis study provided in https://simtk.org/websvn/wsvn/openknee/doc/msm_2015.pdf

All Specifications Pages

1. Specimens

2. Specimen Preparation

3. Data Management

4. Experimentation Anatomical Imaging

5. MRI Scoring

6. Experimentation Joint Mechanics

7. Pressure Calibration

8. Experimentation Tissue Mechanics

9. Experimentation Tissue Thickness

10. Registration

11. Image Segmentation

12. Geometry Generation

13. Mesh Generation

14. Modeling Constitutive

15. Modeling Tissue

16. Simulation Tissue

17. Cloud Computing Prototype

18. FEBio Features

19. Mesh Assembly

20. Modeling Model Graph

21. Modeling Assembly

22. Modeling Compartmental

23. Simulation Compartmental

24. Modeling Kinematics Kinetics

25. Modeling Joint

26. Simulation Joint

27. Pressure Analysis

Experimentation Workflow

The following relates the above flowchart to the corresponding specification page(s). Note the step numbers in the flowchart correspond to the specification pages below. Both this list and the flowchart should be updated if the workflow changes. Pages for specific information on each step of the experimentation process are:

1. Specimens

2. Specimen Preparation

   1. Initial preparation
   2. Preparation for registration
   3. Preparation for anatomical imaging
   4. Preparation for joint testing
   5. Preparation for tissue testing
   6. Supporting Specifications:

   7. Data Management

3. Experimentation Anatomical Imaging

   1. Output: magnetic resonance images for specimen-specific anatomical reconstruction
   2. Supporting Specifications:

   3. Data Management

   4. MRI Scoring

4. Experimentation Joint Mechanics

   1. Output: in vitro joint mechanics (kinematics-kinetics response)
   2. Supporting Specifications:

   3. Data Management

   4. Pressure Calibration

5. Experimentation Tissue Mechanics

   1. Output: in vitro tissue mechanics (stress-strain response)
   2. Supporting Specifications:

   3. Data Management

   4. Experimentation Tissue Thickness

6. Registration

   1. Output: coordinate system transformations (between imaging and experimentation systems)

Modeling & Simulation Workflow

The following list relates the modeling and simulation flowchart above to the corresponding specification pages. Both the list and the flowchart should be updated if the workflow changes. The step numbers in the flowchart correspond to the specification pages as listed:

1. Prerequisite experimentation

   1. Experimentation Anatomical Imaging

   2. Experimentation Tissue Mechanics

   3. Experimentation Joint Mechanics

2. Image Segmentation

3. Geometry Generation

4. Mesh Generation

5. Modeling Constitutive

6. Modeling Tissue

7. Simulation Tissue

   1. Output: specimen specific predictions of tissue mechanics
   2. Supporting Specifications:

   3. Cloud Computing Prototype

   4. FeBio Features

8. Mesh Assembly

   • Supporting Specifications:

   • Modeling Model Graph

9. Modeling Assembly

   • Supporting Specifications:

   • Modeling Model Graph

10. Modeling Compartmental

11. Simulation Compartmental

    1. Output: specimen specific predictions of compartmental mechanics
    2. Supporting Specifications:

    3. Modeling Kinematics Kinetics

    4. Cloud Computing Prototype

    5. FeBio Features

12. Modeling Joint

13. Simulation Joint

    1. Output: specimen specific predictions of joint mechanics
    2. Supporting Specifications:

    3. Modeling Kinematics Kinetics

    4. Pressure Analysis

    5. Cloud Computing Prototype

    6. FeBio Features