ReadySim Wiki

This is the wikipage for the ReadySim project. The development of this project has been managed by Donald Hume and supported by the Center for Orthopaedic Biomechanics at the University of Denver. The work is funded by the National Institute of Biomedical Imaging and Bioengineering (R01EB015497).

The goal of ReadySim is to provide a platform through which researchers can perform musculoskeletal finite element simulations of the lower extremity using the workflow which has been made popular by OpenSim.

ReadySim includes the following components:

A musculoskeletal finite element (MSFE) model of the right lower extremity, developed for ABAQUS/Explicit
A computational framework including modules to scale model segment lengths, estimate kinematics, and optimize muscle forces.

About the MSFE Model

The lower extremity MSFE model has been in development for several years, collaborated on by several researchers, and will likely continue to grow and evolve.

The model includes:

Specimen knee geometry: The lower limb model includes a specimen-specific knee model with bone, cartilage, and ligamentous geometry segmented from CT and MRI. The knee model corresponds to DU02, which was made available through Specimen-Specific Models of the Healthy Knee.
Extensor mechanism: Patellar and Qaudriceps tendon were calibrated to in vitro flexion-extension testing performed on the same subject from which the geometry was obtained (Ali et al., 2016, 2017)
Ligament representation: Ligament response was calibrated to in vitro laxity testing performed on the same subject from which the geometry was obtained (Harris et al., 2016)
Muscle model: Initial muscle geometry and parameters defining force recruitment were based off of a commonly used musculoskeletal model (Delp et al., 2007, Ward et al., 2009). Moment arms and force response at the knee were calibrated to best match in vitro moment arm measurements (Buford et al., 1997) and mean isometric flexion and extension strength response of a healthy subejct cohort (Hume et al. 2018), respectively.
Pelvis and foot geometries were obtained from the Visible Human Project (Ackerman, 1998).

About the Computational Framework

The software package has been developed to allow for single framework musculoskeletal finite element modeling. It provides an avenue to take data directly from the biomechanics lab and perform complex simulations. The software is written as a series of graphical and scripted software in MATLAB with additional scripting written in Python to interface directly with Abaqus input and output files.

The software includes:

Scaling Module: To import optical marker data and scale template musculoskeletal geometry, anthropometry, and parameters defining muscle force recruitment
Kinematics Estimation Module: To import optical marker data from dynamic trials to estimate kinematics
Muscle Force Estimation Module: To import ground reaction forces/moments, and perform static optimization to estimate muscle forces required for a given activity.

Interesting starting points:

RecentChanges: see where people are currently working
WikiSandBox: feel free to change this page and experiment with editing
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HelpOnMoinWikiSyntax: quick access to wiki markup

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