• RecurringMeetings
• 2019-06-04

Recurring Meeting of Cleveland Clinic Core Team

Date: June 4, 2019

Time: 2:00 PM EST

Means: In person meeting

Attendees:

1. Ahmet Erdemir
2. Ariel Schwartz
3. Tammy Owings
4. Ellen Klonowski
5. Sean Doherty
6. Benjamin Landis (phone)

Agenda:

1. Manuscripts.
   1. In vitro ultrasound.
   2. In vitro surgical tools.
   3. In vivo indentation.
   4. Model assembly.
2. Models.
   1. Lumped in vitro.
   2. Lumped in vivo.
   3. Lumped SOFA.
   4. Layered in vitro.
3. Tissue testing.
4. Recap of action items.
5. Other.

Ongoing Action Items:

• Rici
  • Evaluate coordinate systems for in vitro surgical tools manuscript.
  • Prepare in vivo indentation manuscript for resubmission.
• Tyler
  • Submit in vitro ultrasound manuscript.
• Ben
  • Continue work on model assembly paper.
  • Assist Sean with lumped and layered models.
• Sean
  • Continue building layered models.
  • Prepare for SB3C poster on lumped models.
• Ellen
  • Meet with Ahmet to go over tissue testing procedures.
• Ahmet
  • Come up with a morphing strategy for in vivo modeling.
• Tammy
  • None noted.

Notes:

1. Manuscripts.
   • In vitro ultrasound paper is ready for submission. Final coordinate system check will be useful and DOI for data site needs to be obtained.
   • Tyler has written the in vitro surgical tools manuscript; submission will wait for the in vitro ultrasound paper. Rici will double check the coordinate systems for the data sets.
   • Rici will work on the revisions of the in vivo indentation paper. Her goals is to resubmit by the end of June.
   • Ben will check the introduction and devise a strategy to tackle it. Ahmet and Ben will work on sections one by one.
2. Models.
   • Lumped in vitro models were developed and calibrated. They should be on MIDAS (in-house data management site). Sean will check. The models need to be disseminated. Sean will wrap up a publication after SB3C conference.
   • Ahmet needs to come up with a morphing strategy for lumped in vivo models. Ben has been looking into morphing code again and tried to install Python libraries on Windows. He has concerns about not being able to morph the way we like based on data quality and/or discrepancy. Ahmet noted that direct use of data may not be good; optimization may be a possibility. He recommended to start simple; i.e. perform nonuniform scaling by finding three scaling factors in orthogonal directions such that target and morphed length, circumference, and full tissue thickness are equal. Then apply the scaling factor to surfaces. It can be applied to layered models as an optimization.
   • The team can push models into SOFA just fine. There are concerns about parameters for simulation not being optimal; a redo with model reduction is a possibility. The team will wait for finalization of lumped models to intensify these efforts.
   • Sean worked on script to calibrate tissue properties of layered in vitro models. Not much to show at this point. Models meshed based on adaptive meshing are large and Sean is having difficulties to run them. Ahmet recommended using the simplification strategy of Ariel, i.e. making a smaller region of interest deformable, the rest of the mesh as fixed rigid materials. Sean had to switch to FEBio 2.9 due to unknown issues. He still using quadratic tetrahedrals. The boundaries between layers are still noisy when adaptive meshing is used.
3. Tissue Testing.
   • Tissue testing is at a stand still. Ellen is comfortable using the machine and work with test parameters. She read the cartilage paper; she is ready to test skin. She tested the rubber materials; visually the data seems repeatable. Ahmet and Ellen will look at rubber data in more depth before moving to skin. The goal is to get quantitative information on repeatability.
4. Recap of action items.
   • The participants went over the action items.
5. Other.
   • Construction will happen in the laboratory for renovations. Erdemir laboratory will relocate. The team talked about equipment, the need for an inventory and the knowledge to reassemble all in the new lab.