Recurring Meeting of the Advisory Board

Date(s): May 19-30, 2014

Due to scheduling conflicts, the group meeting with the Advisory Board members were scheduled on an individual basis with each member. Please refer to Meeting Minutes for more details.

TableOfContents


Progress Report

Project Specific Aims

Project Infrastructure

Project Contact

Advisory Board

Progress Period

Development Team during Progress Period

See https://simtk.org/project/xml/team.xml?group_id=485 for full details on the project team.

Goals of Progress Period

Please also refer to previous meeting minutes of the Advisory Board at ["RecurringMeetings/2013-10-28"]. For more details, see the ["Roadmap"] and the proposed timeline of the proposal in attachment:GrantInformation/proposal.pdf.

Activities of Progress Period

Details of activities can be found in past meeting minutes of various teams at ["RecurringMeetings"]. For a complete list of various tasks (finished or in progress), please refer to https://simtk.org/pm/?group_id=485.

Plans for Next Progress Period (May 19, 2014 - November 2014)

For more details, see the ["Roadmap"] and the proposed timeline of the proposal in attachment:GrantInformation/proposal.pdf.


Meeting Minutes

Date, Time, Means:

Attendees:

  1. Ahmet Erdemir (Cleveland Clinic)
  2. Yasin Dhaher (Northwestern University)
  3. Trent Guess (University of Missouri)
  4. Rami Korhonen (University of Eastern Finland)
  5. TBD

Agenda:

  1. Progress update, see progress report at:
  2. Recap of previous meeting minutes, see meeting minutes at:
  3. Action items for following meeting.
  4. Other.

Immediate Action Items:

See notes for details.

Notes:

  1. Due to scheduling conflicts, a series of meetings were conducted to inform the Advisory Board about Open Knee(s) activities and get feedback.
  2. Progress update.
    • Ahmet provided a summary of progress by using individual items in the progress report as reference (see above).
    • Ahmet emphasized the full specimen-specificity aimed for Open Knee(s) models and the difficulties in logistics of related data collection. This approach requires collecting tibiofemoral and patellofemoral joint kinematics-kinetics data (with contact pressure for the patellofemoral joint); anatomical imaging of the same joint, along with specimen preparation to accommodate accurate registration between imaging and mechanics data; and the acquisition and testing of tissue samples from the same joint.
    • For tissue modeling, Yasin raised a concern about the in situ strain in ligaments. The knee joint data will be purely specimen-specific, from joint geometry and kinematics-kinetics to tissue stress-strain response. There will not be any explicit measurement of in situ strain, as this is a rather difficult metric to measure. Nonetheless, joint kinematics-kinetics data, particularly under laxity loading, may provide opportunities to calibrate ligament in situ strains with material properties of the ligament determined from tissue testing in a specimen-specific manner.
    • Rami noted that 45 to 60 minutes relaxation time during tissue testing, particularly for ligaments and tensile cartilage and meniscus specimens may not be enough. Ahmet acknowledged this limitation and indicated that tests may be extended to accommodate long relaxation times. This may also depend on measurement and experimentation resolution.
  3. Recap of previous meeting minutes.
    • A few discussions resurfaced from previous meeting minutes.
  4. Action items for following meeting.
    • TBD
  5. Other.
    • Efforts to engage community were emphasized and the Advisory Board was asked to comment on the wiki about specifications. Ahmet also wondered if any of the board members had any ideas to engage the community. He summarized the plan for community internship program he had in his mind. Yasin proposed to reach out to individual laboratories and ask investigators if they have any student that can contribute during summer while they are hosted in their own institute. If a project that benefits both Open Knee(s) and the external investigators research program, this may be a good venue to pro-actively engage the community. Ahmet emphasized that these project should return something to the Open Knee(s) and if that is the case, the internship can be paid by the Open Knee(s). Ahmet also noted that there may be intern candidates who may not be associated with any laboratory or an established investigator but may still provide useful input and work for Open Knee(s). By having a mechanism to reach out such communities may be beneficial. Yasin also advised to have a virtual conference at the end of summer, where all the interns and their principal investigators may interact with each other.