Agent-based model of inflammatory cells, satellite cells, and fibroblasts to study disease mechanisms in Duchenne muscular dystrophy.
This study developed an agent-based model (ABM) of skeletal muscle damage and regeneration in order to investigate the cellular mechanisms of disease in Duchenne muscular dystrophy (DMD). Then model was used to probe the role of these mechanisms first in isolation, and then collectively in computational models of the mdx mouse, the most commonly used mouse model of DMD. The project includes both model output and source code for the ABM.
The model was built in Repast, a Java based modeling platform.