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Can Morphing Methods Predict Intermediate Structures?, D R Weiss, M Levitt, J Mol Biol; 385(2):665-74. (2009)    View

Provide high-fidelity morphed protein trajectories between two known protein conformations.

We present a new morphing method that does not move linearly and can therefore go around high energy barriers, and which can produce different trajectories between the same two starting points. The input are two protein conformations (an initial and final conformation) and an alignment that will define which inter-residue distances are restrained to reach the final structure.


Executable and tutorial of Climber. The tutorial describes how to create all the input files and generate the output files.

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