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VPHOP project will develop, validate and deploy the next generation of technology to predict the risk of fracture in patients with low bone mass, enabling clinicians to provide better prognoses and implement more effective treatment strategies.
Nearly four million osteoporotic bone fractures cost the European health system more than 30 billion Euro per year. This figure could double by 2050. After the first fracture, the chances of having another one increase by 86%. We need to prevent osteoporotic fractures. The first step is an accurate prediction of the patient-specific risk of fracture that considers not only the
skeletal determinants but also the neuromuscular condition. The aim of VPHOP is to develop a multiscale modelling technology based on conventional diagnostic imaging methods that makes it possible, in a clinical setting, to predict for each patient the strength of his/her bones, how this strength is likely to change over time, and the probability that the he/she will overload his/her bones during daily life. With these three predictions, the evaluation of the
absolute risk of bone fracture will be much more accurate than any prediction based on
external and indirect determinants, as it is current clinical practice. These predictions will be used to: i) improve the diagnostic accuracy of the current clinical standards; ii) to provide the basis for an evidence-based prognosis with respect to the natural evolution of the disease, to pharmacological treatments, and/or to preventive interventional treatments aimed to selectively strengthen particularly weak regions of the skeleton. For patients at high risk of fracture, and for which the pharmacological treatment appears insufficient, the VPHOP system will also assist the interventional radiologist in planning the augmentation procedure.
The various modelling technologies developed during the project will be validated not only in vitro, on animal models, or against retrospective clinical outcomes, but will also be assessed in term of clinical impact and safety on small cohorts of patients enrolled at four different clinical institutions, providing the factual basis for effective clinical and industrial exploitations.
News
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Empirica Webinar on Assessing Clinical and Economic Benefits
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Mar 17, 2012The last month was very busy for the VPHOP Consortium.
The first version of the final Hypermodel run successfully
Feb 9, 2012The first version of the Hypermodel of the femoral region, originally due for PM38, but postponed to PM42, was successfully built integrating all five sub-models operating at different dimensional scales and successfully run on PLX platform.
VPHOP: The 3rd Year Outcome Report by the EC Reviewers
Jan 22, 2012The outcome of the third review meeting held in Bologna on 16th-17th January has been presented in a consolidated review report received by the PMO at the beginning of February.
VPHOP 3rd Review Meeting: green light from the EC reviewers
Jan 18, 2012The third Review Meeting was held in Bologna last 16th-17th of January in front of the EC project officer Joel Bacquet and four peer scientists EC reviewers.
3rd VPH study group on VPH Toolkit
Dec 4, 2011The third VPH NoE study group (SG3) will be held in Barcelona in May 2012.
VPHOP abstract accepted for presentation at ECR2012 Imagine
Nov 3, 2011The abstract “Image-based, personalised and multiscale modelling to predict the risk of fracture in osteoporotic patients: the VPHOP integrated project” was one of the 18th selected (from a total of 85 submitted abstracts!) to participate to the “Novel technology that shapes Radiology: EIBIR presents IMAGINE” workshop which will be held during the ECR 2012 in Vienna.
VPHOP 3rd Annual Consortium Meeting
Oct 14, 2011Thanks to the kind offer of Keita Ito, WP6 leader, the 3rd Annual Consortium Meeting will be hosted by the Technische Universiteit Eindhoven - TU/e.
In Vitro Experiments completed at IOR for Augmentation Model
Aug 30, 2011Together with the University of Bern, in vitro experiments were completed at the Istituto Ortopedico Rizzoli to provide validation data for the interventional treatment planning modules.
VPHOP towards end-user applications
Jul 2, 2011The PMO has recently submitted to the EC Project Officer a non-contractual document named "D1.101 Use cases and architectural paradigm".
A new GPU powered system in CINECA (upgrade of PLX)
Jun 22, 2011CINECA and SCS are announcing a very important upgrade of PLX system which reaches now a peak performance near to 300 TFlops, making it the most powerful Supercomputer in Italy.
Statistical modeling of human femurs successfully tested
May 10, 2011The development and validation of algorithms for statistical modeling of shape and mineral density (BMD) of human femurs have now been completed with good results!
EOS imaging: the clinical study is ready to start
Apr 30, 2011On the 23rd of March in Paris it was held an important meeting for the VPHOP project which saw the partecipation of representatives of Arts Association (LBM), EOS imaging (BSP), Institut National de la Santé et de la Recherche Médicale (INS) and Istituto Ortopedico Rizzoli (IOR).
Actibelt technology offers activity profile of patients
Apr 15, 2011Another deliverable of the VPHOP Project has been completed.
Fast FE-solver for nonlinear analyses
Mar 30, 2011On the 21st of January 2011 the deliverable 6.2 of the VPHOP project has been completed.
VPHOP: a summary of the activities of the second year
Feb 11, 2011At the end of the second year of its activities, the Osteoporotic Virtual Physiological Human –VPHOP- research project has made crucial steps upfront for the achievement of the project’s objectives.
University of Geneve starts patients enrollment
Nov 3, 2010The University of Geneve, in collaboration with the NeuroZentrum Zurich, has recently started a VPHOP clinical pre-trial with 30 patients which serves to validate a set of software tools the University of Bern has developed.
PhysiomeSpace: complete female 3D human skeleton model
Jun 28, 2010Super Computing Solutions –SCS- and the Computational Bioengineering Lab –BIC- by the Istituto Ortopedico Rizzoli are happy to announce the release of the first dataset that composes the Living Human Digital Library –LHDL- multiscale musculoskeletal data collection.
PhysiomeSpace: share biomedical data in a free and easy way!
Jun 28, 2010B3C today announces the release of an interactive digital library service, called PhysiomeSpace, designed to manage and share a large collection of heterogeneous biomedical data, such as medical imaging, motion capture, biomedical instrumentation signals, finite element models, etc.
VPHOP gets coverage on Biomedical Computation Review
Jun 23, 2010The summer issue of Biomedical Computation Review, a quarterly journal published by the national Center for Biomedical Computing at Stanford, covers the topic of physiome research.
The European Virtual Physiological Human Institute
Apr 27, 2010To provide strong support for both the European Union Virtual Physiological Human (VPH) research initiative and the global “Physiome” community, the process to establish a European VPH Institute has now officially started.
NMS Physiome started on January 2010
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